An observational study in Congenital Pneumonia and Transient Tachypnea of the Newborn, sponsored by Dr. Behcet Uz Children's Hospital. Completed at 1 site in Turkey (Türkiye). Open to participants aged 1 Hour to 24 Hours. Per ClinicalTrials.gov, last updated 2025-07-30.
Sponsored by Dr. Behcet Uz Children's Hospital · Observational
Accurate and timely differentiation between transient tachypnea of the newborn (TTN) and congenital pneumonia is essential in neonatal care, as it facilitates prompt initiation of appropriate treatment, reduces the risk of complications, and minimizes inappropriate antibiotic use. This study aims to assess the clinical utility of inflammatory markers, including the Systemic Immune-Inflammation Index (SII) and the Systemic Immune-Response Index (SIRI), in distinguishing TTN from congenital pneumonia in neonates. In scenarios where conventional diagnostic methods prove insufficient, these indices may offer clinicians a reliable and objective diagnostic approach, thereby optimizing antibiotic stewardship and reducing the duration of hospitalization.
Patients admitted to the Neonatal Intensive Care Unit of Dr. Behçet Uz Children's Hospital for respiratory distress will be analyzed.
The following data will be recorded in the "case report form" for each patient: age, gender,Score for Neonatal Acute Physiology- Perinatal Extension-II (SNAPPE-II), birth weight (SGA/LGA), mode of delivery (elective/emergency C-section and vaginal delivery), gravidity, parity, maternal age, maternal comorbidities (GDM, preeclampsia/eclampsia, hypothyroidism, chorioamnionitis, urinary tract infection, asthma, obesity, epilepsy), presence of premature rupture of membranes or fever, sibling history, low APGAR score (\<7), leukocyte count, neutrophil count, lymphocyte count, platelet count, monocyte count, aspartate transferase (AST), C-reactive protein (CRP), blood smear test, blood culture, tracheal aspirate culture, antibiotics used and their duration, chest X-ray findings, length of hospital stay, onset and duration of oxygen therapy and method of administration, need for mechanical ventilation, and morbidity and mortality status.
37 studies on the registry are indexed under Transient Tachypnea of the Newborn; 3 are open to participants now.
This study's enrollment of 61 is below the median of 105 across 10 observational studies indexed under Transient Tachypnea of the Newborn.
Browse Transient Tachypnea of the Newborn studies →Dr. Behcet Uz Children's Hospital is the lead sponsor of 28 studies on the registry; 4 are open to participants now.
Counted across the registry records on this site, refreshed daily.
The study population includes term neonates (≥37 weeks of gestation) diagnosed with either transient tachypnea of the newborn (TTN) or congenital pneumonia. All patients are evaluated within the first 24 hours postnatally (0-24 hours). Only neonates admitted to the neonatal intensive care unit (NICU) for respiratory distress are included in the study.
Exclusion Criteria:
patients diagnosed with congenital pneumonia
Diagnostic Test: complete blood count, CRP, blood smear test, blood culture, chest X- ray
patients diagnosed with transient tachypnea of the newborn
Diagnostic Test: complete blood count, CRP, blood smear test, blood culture, chest X- ray
Inflammation markers obtained from all cases will be evaluated and used to differentiate between transient tachypnea of the newborn and congenital pneumonia.
Differentiation of TTN and congenital pneumonia using systemic immune-inflammation index (SII)
The Systemic Immune-Inflammation Index (SII) is a biomarker derived from neutrophil count, lymphocyte count, and platelet count. It has been shown to increase proportionally with the degree of inflammation.
Time frame: within the first 24 hours postnatally
Differentiation of TTN and congenital pneumonia using systemic inflammatory response index (SIRI)
The Systemic Inflammatory Response Index (SIRI) is a biomarker derived from neutrophil count, lymphocyte count, and monocyte count. It has been shown to increase proportionally with the degree of inflammation.
Time frame: within the first 24 hours postnatally
Effectiveness of Inflammatory Markers in Differentiating TTN and Congenital Pneumonia
inflammatory markers such as neutrophil-lymphocyte ratio (NLR), pan-immune-inflammation value (PIV) , platelet-lymphocyte ratio (PLR), AST to platelet ratio index (APRI) typically increase during inflammation, while lymphocyte- monocyte ratio (LMR) generally decreases.
Time frame: within the first 24 hours postnatally
Differentiation of TTN and congenital pneumonia using C Reaktive Protein
CRP has been shown to increase proportionally with the degree of inflammation.
Time frame: 24 hours postnatally
Plan to share: No
This study is completed, as verified in Jul 2025. You cannot join it, but the record below documents what was studied.
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Transient Tachypnea of the Newborn→
Dr. Behcet Uz Children's Hospital