An observational study in Pulmonary Artery Doppler, sponsored by Assiut University. Completed at 1 site in Egypt. Open to female participants. Per ClinicalTrials.gov, last updated 2026-04-07.
Sponsored by Assiut University · Observational
Evaluation of Pulmonary artery Doppler parameters in fetuses of mothers with severe preeclampsia
Preclampsia (PE) represent a major concern in public health, affecting 2-8% of all pregnancies and considered one of the leading causes of perinatal morbidity and mortality. fetal growth restriction (FGR) ia also a common health problem affecting about 5-10% of all pregnancies and commonly associates with preeclampsia . It is estimated that 20% of cases of PE present with FGR and about 50% of early-onset FGR cases will eventually coexist with PE.
Preeclampsia affects about 5% of pregnancies and hypertensive disorders of pregnancy cause over 60,000 maternal fatalities each year around the world .The decision to deliver a woman with severe pre-eclampsia that is far from the term [mid-trimester] is difficult for the obstetrician.In most cases of highly premature pre-eclamptic gestation, certain institutions propose continuing pregnancy until one of the following occurs development of fetal lung maturity, development of fetal or maternal discomfort, or accomplishment of gestational age of 34 to 36-week of gestation .
Numerous tests have been developed in an attempt to identify if fetal lung maturation has reached a level sufficient to prevent the development of fetal RDS. These tests are based on four core themes: biochemical testing for active surfactant components, biophysical testing for surfactant functionality, physical testing of amniotic fluid opacity, and ultrasound examination of the fetuses and their tissues . Neonatal RDS has been predicted using fetal pulmonary artery Doppler. Kim and colleagues discovered that a high PAT/ET was linked to newborn RDS .The development of RDS in preterm newborns is linked to an increased acceleration time to ejection time [AT/ET] ratio in the fetal pulmonary artery .
882 studies on the registry are indexed under Pre-Eclampsia; 237 are open to participants now.
This study's enrollment of 86 is below the median of 163 across 380 observational studies indexed under Pre-Eclampsia.
Browse Pre-Eclampsia studies →Assiut University is the lead sponsor of 4,901 studies on the registry; 2,098 are open to participants now.
Of its 13 completed or terminated interventional studies of FDA-regulated products, 0 (0%) have results posted.
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Pregnant woman with preeclampsia
Exclusion Criteria:
The four chamber view, outflow tract views, triple vessel view, longitudinal view of the aortic arch and ductal arch, and colour flow mapping will be used for a comprehensive examination to assess structural heart integrity and rule out cardiac defects. Pulmonary artery is detected and power Doppler cursor is put on it just beyond pulmonary valve and indices are calculated.
Radiation: Pulmonary artery Doppler ultrasound
Doppler ultrasound of fetal pulmonary artery
Pulmonary Doppler resistance index
Pulmonary Doppler index in fetus of preeclamptic mother
Time frame: 1 month
This study is completed, as verified in Apr 2026. You cannot join it, but the record below documents what was studied.
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Assiut University