An interventional study of Low-volume, high-intensity interval training and Standart medical treatment in High Intensity Interval Training, Heart Failure and Exercises, sponsored by Tarsus University. Recruiting at 2 sites in Turkey. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2025-01-03.
Sponsored by Tarsus University · Not applicable, Interventional, and Treatment
This study was planned to investigate the effects of upper extremity low-volume high-intensity interval training (LV-HIIT) on physical and cognitive function in patients with heart failure with preserved ejection fraction(HFpEF).The research was planned as a randomized controlled trial. Patients with clinically stable HFpEF at cardiology clinic will be included in the study. These cases will be randomly divided into two groups: intervention group and control grup. After 8 weeks intervention physical functions before and after treatment; functional exercise capacity, arm exercise capacities , peripheral muscle strength , fatigue cognitive functions; anxiety and depression and fear of movement will be evaluated.
Patients in the DV-HIIT group will receive training consisting of 4 minutes of warm-up and cool-down at 50% Wmax on an arm ergometer, 1 minute of training at 85-95% Wmax work intensity, followed by 6 interval training periods including 1 minute of active recovery periods at 50-70% Wmax, 2 days/week, totaling 8 weeks of training. The control group will be followed with standard medical treatment.
5,701 studies on the registry are indexed under Heart Failure; 1,220 are open to participants now.
This study's planned enrollment of 30 is below the median of 72 across 3,736 interventional studies indexed under Heart Failure.
Browse Heart Failure studies →Tarsus University is the lead sponsor of 78 studies on the registry; 29 are open to participants now.
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Exclusion Criteria:
History of CABG surgery
İntervention Group: LV-HIIT
Other: Low-volume, high-intensity interval training
Control group
Drug: Standart medical treatment
Low-volume, high-intensity interval training with an arm ergometer will be given two days a week for a total of eight weeks.
Standart medical teatment
maximal arm exercises capacity
maximal arm exercises capacity will measurement with arm ergometer test.
Time frame: At baseline and after 8 week
Functional capacity
Functional capacity will be assessed with the six-minute walk test (6MWT).
Time frame: At baseline and after 8 week
Upper extremity muscle strength
Upper extremity muscle strength will be evaluated with a digital dynamometer and hand grip strength will be evaluated with a jamar.
Time frame: At baseline and after 8 week
reaction time
The auditory and visual reaction times of the individuals will be determined. The instrument used during the test can give three stimuli and consists of two parts, In measuring the reaction times, care will be taken to ensure that the measurement area is a noiseless and light-receiving environment. Individuals will be told the technique of the test and will be asked to make 1 attempt against sound and light stimulation. After the trial, 3 measurements will be taken and the results will be recorded in milliseconds
Time frame: At baseline and after 8 week
cognitive function
Mini mental Questionaire will use. Min 24 point is the cut of for this test
Time frame: At baseline and after 8 week
Postural sway
The postural oscillations of the patients will be evaluated with the body oscillation device, which measures the oscillation in two axes. In this test, the participant will be asked to stand in the upright position with a distance of 10 cm between the two feet and to maintain your upright position for 30 seconds. The participant will be measured twice with the eyes open and closed. With these measurements, the mediolateral and anteroposterior oscillation distances of the patients will be measured and recorded on the computer
Time frame: At baseline and after 8 week
heart rate variablity
Time frame: At baseline and after 8 week
hand steadness
The auditory and visual reaction times of the individuals will be determined. The instrument used during the test can give three stimuli and consists of two parts, In measuring the reaction times, care will be taken to ensure that the measurement area is a noiseless and light-receiving environment. Individuals will be told the technique of the test and will be asked to make 1 attempt against sound and light stimulation. After the trial, 3 measurements will be taken and the results will be recorded in milliseconds.
Time frame: At baseline and after 8 week
Anxiety and depresion
Hospital anxiety and depression Scale is a self-report rating scale of 14 items on a 4-point Likert scale (range 0-3). It is designed to measure anxiety and depression (7 items for each subscale). The total score is the sum of the 14 items, and for each subscale the score is the sum of the respective seven items (ranging from 0-21). It is worth noting that items referring to depression symptoms that describe somatic aspects of depression (e.g. insomnia and weight loss) are not included in the scale.
Time frame: At baseline and after 8 week
activities of daily living
Nottingham Health Profile (NHP) will used. The questionnaire is divided into two parts. The first parts comprises 38 questions in six categories: sleep, physical mobility, energy, pain, emotional reactions, and social isolation.The second part of the NHP is made up of seven statements about areas of life that are commonly affected by health: paid employment, jobs around the house, social life, personal relationships, sex life, hobbies and interests, and holidays. Scores on the NHP can range from 0 i.e. no distress to 100 i.e severe distress.
Time frame: At baseline and after 8 week
Plan to share: No — All IPD collected throughout the trial, only IPD used in the results publication
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