An interventional study of Lower body resistance training in Aging and Muscle Hypertrophy, sponsored by University of Sao Paulo General Hospital. Completed at 1 site in Brazil. Open to participants aged 60 Years and older. Per ClinicalTrials.gov, last updated 2024-12-11.
Sponsored by University of Sao Paulo General Hospital · Not applicable, Interventional, and Other
The study aimed to investigate the effects of resistance training volume manipulation on whole muscle hypertrophy among non-responders and responders to a low resistance training dose (single-set).
The magnitude of muscle hypertrophy in response to resistance training (RT) is highly variable between individuals (response heterogeneity). Manipulations in RT variables may modulate RT-related response heterogeneity; yet, this remains to be determined.
656 studies on the registry are indexed under Hypertrophy; 87 are open to participants now.
This study's enrollment of 102 is above the median of 50 across 460 interventional studies indexed under Hypertrophy.
Browse Hypertrophy studies →University of Sao Paulo General Hospital is the lead sponsor of 595 studies on the registry; 98 are open to participants now.
Of its 8 completed or terminated interventional studies of FDA-regulated products, 0 (0%) have results posted.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
One set of unilateral knee-extension exercise of 8-15 RM with a 60-90 s interval.
Other: Lower body resistance training
Four sets of unilateral knee-extension exercise of 8-15 RM with a 60-90 s interval between sets.
Other: Lower body resistance training
The RT protocol was performed using a unilateral knee-extension machine. To reduce potential sources of bias to exercise order, subjects alternated the starting leg for each training session.
Quadriceps muscle cross-sectional area
Quadriceps muscle CSA was obtained through magnetic resonance imaging.
Time frame: 10 weeks
Maximum dynamic strength
Unilateral quadriceps 1-RM of both legs were assessed on a knee-extension machine
Time frame: 10 weeks
Dietary assessment
Dietary assemment using the USDA Automated Multiple-Pass Method
Time frame: Before intervention
Mass spectrometry
Mass spectrometry metabolomics
Time frame: 10 weeks
Skeletal muscle RNA-sequencing
RNA sequencing using an Illumina NovaSeq Platform with a standard paired-end 150 bp (PE150) dual indexing protocol
Time frame: 10 weeks
Muscle protein measures
Upstream binding factor (UBF) muscle protein was quantified by Simple Western capillary immunoassay.
Time frame: 10 weeks
Muscle protein measures
v-Myc Avian Myelocytomatosis Viral Oncogene Homolog (c-Myc) muscle protein was quantified by Simple Western capillary immunoassay.
Time frame: 10 weeks
Muscle protein measures
Frizzled class receptor 1 (Frizzled-1) muscle protein was quantified by Simple Western capillary immunoassay.
Time frame: 10 weeks
Muscle protein measures
ribosomal protein L3 (rpL3) muscle protein was quantified by Simple Western capillary immunoassay.
Time frame: 10 weeks
Plan to share: No
No publications or documents are linked to this record.
This study is completed, as verified in Nov 2024. You cannot join it, but the record below documents what was studied.
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University of Sao Paulo General Hospital