An interventional study of Vestibular evoke myogenic potential in Noise and Vestibular Disorder, sponsored by Taipei City Hospital. Completed at 1 site in Taiwan. Open to participants aged 20 Years to 40 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2024-12-02.
Sponsored by Taipei City Hospital · Not applicable, Interventional, and Basic science
This study aims to evaluate the effects of different masking conditions on cervical vestibular evoked myogenic potential (cVEMP) responses. Vertical-axis vibrations (VAVs) of 500-Hz short-tone bursts (STB500) and 750-Hz short-tone bursts (STB750) were used to elicit cVEMP responses. These stimuli were delivered through a Mini-Shaker placed at the vertex (Cz) under three masking conditions: no masking (NOM), speech noise masking (SNM), and random interstimulus-interval tone bursts (rISITB). The study focused on testing protocols that can potentially improve unilateral VEMP testing and explore its clinical applicability.
Participants and Ethics:
The study recruited 20 healthy adults (10 males and 10 females, aged 20-37 years), all of whom had normal otoscopic findings and no history of hearing issues. Ethical approval was obtained, and all participants provided informed consent.
Bone Conduction Vibrations (BCV):
Bone-conducted vibrations were generated using a SmartEP system and delivered via a Mini-Shaker transducer. Stimuli included 500 Hz and 750 Hz short-tone bursts (STB500 and STB750), calibrated to appropriate levels, with specific rise, plateau, and fall times.
Masking Conditions:
Masking sounds included speech noise (250-1000 Hz, calibrated at 100 dB SPL) and random interstimulus-interval tone bursts (rISITB, 500 Hz, 100 dB SPL).
Testing Procedure:
Vertical-axis BCV was delivered to the vertex (Cz) while participants maintained steady neck muscle tension in specified head positions. Electrodes were placed using a standard montage for cVEMP recording. Each side was tested under three masking conditions (NOM, SNM, rISITB) with a 24-hour interval between tests. Responses were recorded bilaterally and repeated for reproducibility.
Study Focus:
The study investigates the effects of different masking conditions on response characteristics, including latencies, amplitudes, and asymmetry ratios. The aim is to refine VEMP testing protocols, explore its potential for unilateral testing, and evaluate its applicability for specific vestibular organ assessments.
172 studies on the registry are indexed under Vestibular Diseases; 41 are open to participants now.
This study's enrollment of 20 is below the median of 44 across 130 interventional studies indexed under Vestibular Diseases.
Browse Vestibular Diseases studies →Taipei City Hospital is the lead sponsor of 56 studies on the registry; 9 are open to participants now.
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Exclusion Criteria:
one test group with different test conditions
Diagnostic Test: Vestibular evoke myogenic potential
routine Vestibular test
Vemp response rate
This study investigates VEMP response rates under different frequencies (500 Hz, 750 Hz) and masking conditions (no masking, speech noise, random tone bursts) to evaluate the effects of masking on VEMP responses.
Time frame: up to 24 weeks
This study is completed, as verified in Nov 2024. You cannot join it, but the record below documents what was studied.
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Taipei City Hospital