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CompletedNCT06656039Updated Oct 24, 2024

A Multimodal Predictive Recurrence Score for Patients With Clear Cell Renal Cell Carcinoma

An observational study in Renal Cell Carcinoma, Clear Cell, sponsored by RenJi Hospital. Completed at 1 site in China. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2024-10-24.

Sponsored by RenJi Hospital · Observational

Study type
Observational
Model
Cohort
Time perspective
Retrospective
Enrollment
1,200
Ages
18 Years and older
Sex
All
01

Study summary

The main goal of this observational study is to construct a predictive recurrence model for renal clear cell carcinoma through an artificial intelligence multimodal algorithm, which will improve the prognosis and survival time of ccRCC patients by helping clinicians to formulate individualised follow-up and to screen for appropriate adjuvant therapy candidates.

02

Conditions studied

  • Renal Cell Carcinoma, Clear Cell

Keywords

  • Renal Cell Carcinoma
  • Multimodal
  • Artificial Intelligence
  • Prognosis
  • Deep Learning
  • Multicentre Study
03

In context

Carcinoma

6,741 studies on the registry are indexed under Carcinoma; 1,161 are open to participants now.

This study's enrollment of 1,200 is above the median of 149 across 1,175 observational studies indexed under Carcinoma.

Browse Carcinoma studies →

Lead sponsor

RenJi Hospital is the lead sponsor of 535 studies on the registry; 244 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

Pathologically confirmed postoperative patients with renal clear cell carcinoma of TNM stage I-III

Inclusion criteria

  • Patients with malignant renal tumours must have postoperative pathological confirmation of renal clear cell carcinoma with pathological TNM stage Ⅰ-Ⅲ;
  • Have available preoperative imaging
  • Have available post-operative pathological paraffin samples or HE-stained tissue sections
  • Must agree to and be able to comply with the study's visit schedule and other requirements as specified in the protocol, including follow-up visits by telephone

Exclusion criteria

Exclusion Criteria:

  • The patient's tumour type cannot be determined on the basis of histopathological sections
  • Simultaneous combination of primary tumours at other sites;
  • No regular follow-up imaging data
  • Cases in which other factors led the investigator to believe that enrolment was inappropriate
  • Cases that met all the inclusion criteria of the appeal and did not meet all the exclusion criteria were selected for this study
05

Study design

Observational model
Cohort
Time perspective
Retrospective
Enrollment
1,200 participants (actual)
Patient registry
No
Biospecimen retention
Samples without dna

Groups and cohorts

  • Training cohort
  • Validation cohort
  • Test cohort
06

What researchers measure

Primary outcomes

  1. Disease free survival

    Defined as from surgery to tumor recurrence or follow-up deadline

    Time frame: "Baseline, immediately after the surgery", "Tumour recurrence or further follow-up", "Three months after surgery", "Six months after surgery", "Every year after surgery, at least follow-up 2years, up to 10 years"

07

Study locations

1 site
  • Renji Hospital
    Shanghai, Shanghai 200120, China
08

References and documents

Individual participant data

Plan to share: Yes — Data will be made available to interested research partners upon reasonable request to Zhaiwei or Department of Urology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.; the prerequisite for this is a data transfer agreement, approved by the legal departments of the requesting researcher and by all legal departments of the institutions that provided data for the study, and an ethics clearance.

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Oct 24, 2024, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT06656039
Lead sponsor
RenJi Hospital
Collaborators
The First Affiliated Hospital of Anhui Medical University, The Fourth Affiliated Hospital of Harbin Medical University, Second Affiliated Hospital of Soochow University, Qianfoshan Hospital, Chang Gung Memorial Hospital
Responsible party
Sponsor
First posted
Oct 24, 2024
Start date
Jan 1, 2024
Primary completion
Oct 10, 2024
Completion
Oct 10, 2024
Last update
Oct 24, 2024

Oversight

Data monitoring committee
Yes
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Oct 2024. You cannot join it, but the record below documents what was studied.

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