An observational study in Carbon Monoxide Intoxication, sponsored by Nantes University Hospital. Recruiting at 2 sites in France. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2025-12-09.
Sponsored by Nantes University Hospital · Observational
The main goal of COCAP is to compare COHb (carboxyhemoglobin) levels measured from venous or arterial samples with those measured from capillary samples in patients suspected of Carbon Monoxide intoxication.Patient participation in the study will be limited to capillary sampling (approx. 5-15 minutes).
42 studies on the registry are indexed under Carbon Monoxide Poisoning; 9 are open to participants now.
This study's planned enrollment of 120 is above the median of 104 across 25 observational studies indexed under Carbon Monoxide Poisoning.
Browse Carbon Monoxide Poisoning studies →Nantes University Hospital is the lead sponsor of 825 studies on the registry; 195 are open to participants now.
Counted across the registry records on this site, refreshed daily.
The study population will consist of patients admitted to adult emergency departments with suspected carbon monoxide intoxication.
Exclusion Criteria:
The study population must correspond to the research inclusion criteria: Adult patient admitted to the emergency department, presenting with one or more clinical signs (asthenia, headache, nausea, vomiting, loss of consciousness, etc.) and a history compatible with CO intoxication (collective symptoms, notion of smoke, activation of a detector, etc.)
Diagnostic Test: Blood drop sampling
The process: blood drop sampling Technique: capillary sampling Frequency: Once Time: 5 minutes Sample collection volume: 1mL Total collection volume: 1 mL
Determine the accuracy of capillary HbCO measurement (compared with venous or arterial HbCO) in patients with suspected CO poisoning.
The main goal will be determined by the mean bias and limits of agreement between capillary and venous (or arterial) sampling (Bland-Altman analysis).
Time frame: 15 minutes
Determine the diagnostic performance of capillary measurement
Determine the sensitivity, specificity, ROC curve, area under the ROC curve, positive and negative predictive values and likelihood ratios (positive and negative) of capillary measurement for the diagnosis of CO intoxication. The linear correlation coefficient between venous (or arterial) HbCO and capillary HbCO will also be calculated.
Time frame: 15 minutes
Assess the technical difficulties of different blood sampling processes (Measurement of the number of attempts and failure rate for samples)
Time frame: 15 minutes
Assess the technical difficulties of different blood sampling processes (Measurement of the time required to take each sample)
Time frame: 15 minutes
Analyse the technical difficulties associated with the analysis of the two samples (Time between sampling and HbCO result)
Time frame: 15 minutes
Analyse the technical difficulties associated with the analysis of the two samples (percentage of samples that cannot be analysed by the laboratory)
Time frame: 15 minutes
Plan to share: Undecided
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Nantes University Hospital