An interventional study of Imagined muscle contractions in Healthy, sponsored by Kennesaw State University. Recruiting at 1 site in United States. Open to participants aged 18 Years to 30 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2024-10-09.
Sponsored by Kennesaw State University · Not applicable, Interventional, and Basic science
The goal of this randomized clinical trial is to learn if imagining fast or slow muscle contractions causes different responses for nervous system excitability and muscle function in young, healthy males and females in. The main questions are:
Does imagining fast muscle contractions cause greater nervous system excitability compared to imagining slow muscle contractions?
Does imagining fast muscle contractions increase muscle function compared to imagining slow muscle contractions?
A control condition (rest) will be compared with two intervention conditions: imagining fast and imagining slow conditions, to determine if the fast and slow increase outcomes more than control and if fast has the greatest response.
Participants will:
Participants will complete 4 laboratory visits in a randomized order, including a familiarization session, a control condition, and 2 conditions involving imaginary muscle contractions. During visits involving imaginary muscle contractions, participants will complete 2 sets of 25 repetitions of either fast (i.e., less than 1 second to peak torque increase torque as fast as possible) or slow (i.e., 3 seconds to peak torque) isometric elbow flexions. Before and after each condition, single-pulse transcranial magnetic stimulation will be delivered to the primary motor cortex to measure the amplitude of motor-evoked potentials and the duration of the resulting silent periods in the bicep brachii to quantify changes in corticospinal excitability and inhibition, respectively. Rapid maximal voluntary isometric contractions will be used to measure changes in rate of torque development, peak torque, and rate of muscle activation.
Kennesaw State University is the lead sponsor of 9 studies on the registry; 5 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Participants will rest quietly with eyes closed during the control condition.
Participants will imagine 2 blocks of 25 fast muscle contractions separated by 30 sec
Behavioral: Imagined muscle contractions
Participants will imagine 2 blocks of 25 slow muscle contractions separated by 30 sec
Behavioral: Imagined muscle contractions
The intervention involved imagining, with no physical movement, of muscle contractions.
Change in rate of torque development as measured by newton-meters per second
A measure of the capacity to increase muscle torque rapidly as determined by the slope of the torque-time curve
Time frame: Baseline, minute 20
Change in nervous system excitability as measured by electromyographic waveform aplitude following motor cortex stimulation
A measure of excitability for the corticospinal tract
Time frame: Baseline, minute 20
Change in isometric bicep strength as measured by newton-meters of torque
Isometric strength of a muscle
Time frame: Baseline, minute 20
Change in agonist muscle activation as measured by electromyography amplitude
A measure of the capacity at which the muscle is activated by the nervous system
Time frame: Baseline, minute 20
Change in antagonist co-activation as measured by electromyography amplitude
A measure of the capacity at which the antagonist muscle is activated by the nervous system
Time frame: Baseline, minute 20
Change in rate of agonist muscle activation as measured by electromyography amplitude
A measure of how quickly the nervous system activates the muscle
Time frame: Baseline, minute 20
Change in nervous system inhibition as measured by electromyographic waveform aplitude following motor cortex stimulation
A measure of inhibition for the corticospinal tract
Time frame: Baseline, minute 20
Self-reported ability to imagine movements as measured by Movement Imagery Questionnaire-Revised as measured on a scale from 8 to 56
Survey that estimates one's capacity to imagine movement. A higher score indicates better imagination.
Time frame: Baseline
Level of vividness for imagining the imagined contractions as measured by 7-point likert scale as measured from 1 to 7
A 7-point likert scale is used to to determine how vivid one's imagination was for the conditions. A higher score indicates greater difficulty imagining the movement.
Time frame: 20 minutes after baseline
Plan to share: Yes — Non-identifying IPD will be provided upon a reasonable request.
No publications or documents are linked to this record.
Eligibility is decided by the study team. Share this record with your doctor or contact the team directly.
Contact study teamGet an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
Kennesaw State University