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Active, not recruitingNCT06610006Updated Sep 24, 2024

Combined Effects of Isometric Wall Squats and High Intensity Interval Training on Rate Pressure Product in Normotensive and Pre-hypertensive Sedentary Adults

An interventional study of High Intensity Interval Training (HIIT) and Isometric Wall Squat in Pre Hypertension, sponsored by Foundation University Islamabad. Active, not recruiting at 1 site in Pakistan. Open to participants aged 18 Years to 45 Years. Per ClinicalTrials.gov, last updated 2024-09-24.

Sponsored by Foundation University Islamabad · Not applicable, Interventional, and Treatment

From the registry’s dates

  • Primary completion was expected by Dec 2024, 1 year 11 months ago, but the record still lists the study as active, not recruiting.
  • Registered 3 months after the study started (first participant enrolled Jun 2024, registered Sep 2024).
Phase
Not applicable
Study type
Interventional
Enrollment
44
Allocation
Randomized
Ages
18 Years to 45 Years
Sex
All
01

Study summary

Hypertension is leading yet preventable risk factor for cardiovascular disease and all-cause mortality worldwide. Prehypertension identifies those at high risk of developing HTN, prompting intervention to prevent or delay the onset of the disease. High intensity interval training (HIIT) is a time efficient mode of training with established benefits, while Isometric wall squats (IWS) also provide a range of proven benefits and advantages, but their combined effect on BP measures is yet to be determined.Hence the objective of this study is to compare the effects of isometric wall squats along with high intensity interval training versus high intensity interval training alone on rate pressure product, SBP and DBP, heart rate and anthropometric measures in normotensive and pre-hypertensive sedentary adults

Read the detailed description

Pre-Hypertension is not a disease itself rather it categorizes those who are at the risk of developing hypertension in future. By targeting pre-hypertensive and normotensive individuals we are focusing on preventive measures, potentially reducing incidence of HTN and cardiovascular conditions in future. If found effective, this study can help in providing training protocols while also decreasing the risk of hypertension in future.A total of 15 sessions of high intensity interval training alone in one group and combination of high intensity interval and isometric wall squat in other group, for thrice a week on alternative days for 5 consecutive weeks will be given.

02

Conditions studied

  • Pre Hypertension

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03

In context

Prehypertension

158 studies on the registry are indexed under Prehypertension; 21 are open to participants now.

This study's planned enrollment of 44 is below the median of 66 across 138 interventional studies indexed under Prehypertension.

Browse Prehypertension studies →

Lead sponsor

Foundation University Islamabad is the lead sponsor of 255 studies on the registry; 142 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 45 Years
Sexes eligible
All
Accepts healthy volunteers
No

Eligibility criteria

Inclusion Criteria:

  • Both male and female adults aged 18-45 years.
  • Participants lying in Low PA (inactive) category on basis of IPAQ.
  • Pre-hypertensive adults:
  • SBP- 120 mmHg or more and \<140 mmHg
  • DBP of 80 mmHg or more and \< 90 mmHg.
  • Normotensive adults: SBP \< 120 mmHg and DBP \< 80 mmHg. Exclusion Criteria
  • Diagnosed with any current infections.
  • Subjects with any diagnosed cardiovascular or respiratory conditions.
  • Subjects with diagnosed musculoskeletal or neurological conditions which hinder participation in physical activity program.
  • Active Smokers
  • Those with any to exercise testing or training.
  • Pregnant females
Terms in these criteria, in plain language(1)

Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.

Contraindication

A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.

05

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
None (open label)
Enrollment
44 participants (estimated)

Study arms

  • Active comparator
    High Intensity Interval Training

    Participants will begin with warm-up exercises for 5-7 mins before the session. Then they will begin high intensity interval training on treadmill with moderate intensity (40-60%HRR) in week 1 to achieve the baseline fitness level and from week 2 to 5 they will progress to high intensity with setting the lower target HR 40-60%HRR and upper target HR 80-85%HRR with 1:4 work to rest ratio followed by 5-7 min of cool-down period.A total of 15 sessions for thrice a week on alternative days for 5 consecutive weeks will be given

    Procedure: High Intensity Interval Training (HIIT)

  • Experimental
    High Intensity Interval Training (HIIT) and Isometric Wall Squat

    High intensity interval training on treadmill with moderate intensity (40-60%HRR) in week 1 to achieve the baseline fitness level and from week 2 to 5 they will progress to high intensity with setting the lower target HR 40-60%HRR and upper target HR 80-85%HRR with 1:4 work to rest ratio. For isometric wall squat, each training session will be composed of 4 × 2-min bouts of IWS followed by 2-min rest periods At the end of each bout, participants will be given an RPE score. This score will then be compared to a target RPE value and zone for each bout, There will be total 15 sessions thrice a week for 5 weeks.

    Procedure: High Intensity Interval Training (HIIT) · Procedure: Isometric Wall Squat

Interventions

  • ProcedureHigh Intensity Interval Training (HIIT)

    High intensity interval training on treadmill with moderate intensity (40-60%HRR) in week 1 to achieve the baseline fitness level and from week 2 to 5 they will progress to high intensity with setting the lower target HR 40-60%HRR and upper target HR 80-85%HRR with 1:4 work to rest ratio followed by 5-7 min of cool-down period..A total of 15 sessions of high intensity interval training alone , for thrice a week on alternative days for 5 consecutive weeks will be given. Warm-up session consisting of stretching exercises prior to intervention and cool down session after intervention will also be done and vitals before and after the session will be taken.

  • ProcedureIsometric Wall Squat

    For isometric wall squat, each training session will be composed of 4 × 2-min bouts of IWS followed by 2-min rest periods. In first week, participants will do squat training or there will be a protocol for selecting exercise intensity in which participants will be given 30-s to perform a wall squat to select a position that they predict would elicit an target RPE score by varying the squat height. Based on the final squat height and RPE score, after bout 4, participants will be given a starting squat height for training session 1 and will then be progressed in each week

06

What researchers measure

Primary outcomes

  1. Rate Pressure Product

    Measured by multiplying Heart Rate and Systolic Blood Pressure

    Time frame: 5 weeks

  2. Blood Pressure(SBP and DBP)

    Evaluation will be done using sphygmomanometer

    Time frame: 5 weeks

  3. Heart rate

    Heart Rate will be measured using pulse oximeter.

    Time frame: 5 weeks

  4. Anthropometric Measures Waist circumference

    Measuring Tape will be used to measure Waist circumference

    Time frame: 5 weeks

  5. Anthropometric Measures hip circumference

    Measuring Tape will be used to measure hip circumference

    Time frame: 5 weeks

  6. Anthropometric Measures Waist to hip ratio

    Ratio of waist circumference and hip circumference

    Time frame: 5 weeks

  7. BMI

    Body mass index ratio of weight and height

    Time frame: 5 weeks

07

Study locations

1 site
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Sep 24, 2024, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT06610006
Responsible party
Sponsor
First posted
Sep 24, 2024
Start date
Jun 10, 2024
Primary completion
Dec 10, 2024 (estimated)
Completion
Dec 15, 2024 (estimated)
Last update
Sep 24, 2024

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is active, not recruiting, as verified in Sep 2024. You cannot join it, but the record below documents what was studied.

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