An observational study in Obesity and Type 2 Diabetes, Bariatric Patients Undergoing Bariatric Surgery and Adipose Tissue Dysfunction Type 2 Diabetes Mellitus Bariatric Surgery, sponsored by Concordia University, Montreal. Recruiting at 1 site in Canada. Open to participants aged 18 Years to 65 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2024-10-22.
Sponsored by Concordia University, Montreal · Observational
Fat tissue in different parts of the body has different characteristics. Several studies have associated abdominal fat to an increased risk for multiple metabolic diseases, such as type 2 diabetes and cardiovascular disease, compared with fat located under the skin at the hips and thighs. However, the investigators do not know how the abdominal fat causes or contributes to the development of these diseases or how the development of these disease may in turn cause or contribute to changes in the fat tissue. The general objective of this study is to understand these mechanisms.
To investigate these questions, the study will recruit 140 participants, both men and women aged 18-65 years. The participants will be divided into three groups: 40 people with obesity, 40 with diabetes, and 60 lean individuals. Participants will be recruited from patients at the CIUSSS du Nord-de-l'Île-de Montréal - Hôpital du Sacré-Coeur de Montréal who are awaiting bariatric or general abdominal surgery, as well as from the general population in the Montreal area.
6,570 studies on the registry are indexed under Obesity; 1,718 are open to participants now.
This study's planned enrollment of 140 is close to the median of 132 across 1,338 observational studies indexed under Obesity.
Browse Obesity studies →Concordia University, Montreal is the lead sponsor of 22 studies on the registry; 7 are open to participants now.
Counted across the registry records on this site, refreshed daily.
The Diabetes and Obese groups will be recruited from patients scheduled to undergo bariatric surgery in Montréal and the lean participants will be recruited from healthy patients scheduled to undergo general surgery.
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Exclusion Criteria:
Healthy participants without obesity
Participants with obesity undergoing bariatric surgery
Participants with diabetes undergoing bariatric surgery
Immune Cell Quantification
Flow Cytometry will be used to quantify immune cells in the fat tissue.
Time frame: 5 years
Pre-adipocytes and adipocyte characteristics
Cellular characteristics such as proliferation, differentiation and cellular senescence will measured.
Time frame: 5 years
Blood Inflammatory Markers
The inflammatory cytokines (e.g. IL6, TNFα), chemokines (e.g. monocyte chemoattractant protein-1), genomics, and adipokines (e.g. leptin, adiponectin) in blood and adipose tissue via PCR, luminex or ELISA will be measured
Time frame: 5 years
Plan to share: No
No publications or documents are linked to this record.
Started May 2016 (actual). Primary completion is estimated for Apr 2025, 107 months after the start.
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Concordia University, Montreal