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Enrolling by invitationNCT06724393Updated Dec 9, 2024

Blood Flow Restriction and Functionality in Older Adults

An interventional study of Blood flow restrictions in combination with low-intensity resistance training in Older Adults (65 Years and Older), Older Adults At Risk of Falling and Blood Flow Restriction (BFR) Training Effects, sponsored by Concordia University, Montreal. Enrolling by invitation at 1 site in Canada. Open to participants aged 60 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2024-12-09.

Sponsored by Concordia University, Montreal · Not applicable, Interventional, and Prevention

From the registry’s dates

  • Primary completion was expected by Jun 2025, 1 year 4 months ago, but the record still lists the study as enrolling by invitation.
  • Registered 7 months after the study started (first participant enrolled May 2024, registered Dec 2024).
Phase
Not applicable
Study type
Interventional
Enrollment
30
Allocation
Randomized
Ages
60 Years and older
Sex
All
01

Study summary

Resistance training is beneficial for stimulating muscle and bone growth and is uniquely important for older adults to avoid frailty and to maintain bone density. Seniors tend to be anxious to use a large resistance or try heavier weights as it is not common for them to exercise this way. Therefore, blood flow restriction is a fantastic way to increase intensity while keeping the resistance low. Wearing blood flow restriction straps allows the muscles to adapt to working at a lower oxygen pressure, therefore, mimicking a higher intensity. Additionally, as we age, oxygen consumption decreases, commonly due to loss of lean body mass and a reduced maximum heart rate. However, resistance training can counteract these declines by reducing the resting heart rate and improving cardiac output, therefore, bettering oxygen consumption.

The study will consist of 10 weeks of resistance exercises performed twice per week. The classes will be open to seniors of 60 years of age or older. The classes will be held on zoom- allowing for easy access, no travel and an opportunity for seniors to be active in their own home. The exercises will consist of general resistance training movements focusing all the major muscle groups. One group of seniors will wear blood flow restriction bands on both legs at the upper thigh and a control group which will complete the same exercise classes with no restriction.

Before, at midpoint and after the 10 weeks, the participants will perform strength tests using the BIODEX and three functional tests focusing on the lower extremity. There will be a practice trial for all the functional tests where results are not recorded. Once the practice is completed, the participants will have one trial of each test. The BIODEX is a dynamometer that allows testing in many different settings including rehabilitation. During the functional tests, the participants will be asked to wear a VO2 non-invasive mask (VO2 Master) to measure their oxygen consumption. The functional tests will include:

  • Sit to stand: rise from a chair as many times as possible without using hands or arm rests to help.
  • Timed up a go: Rise from a chair and walk 8ft as fast as possible without running and return to sit on the chair.
  • Sitting-rising test: lowering to the floor and coming back up without using hands, knees or arms.

Thus, the purpose of this study is three-fold: 1) To assess the effects of the 10-week online exercise intervention on strength and functionality 2) To assess the effects of the 10-week intervention on oxygen consumption using a VO2 non-invasive mask and 3) To assess if the addition of blood flow restriction over a 10-week intervention increases the improvements in strength and oxygen consumption compared to the control group.

02

Conditions studied

  • Older Adults (65 Years and Older)
  • Older Adults At Risk of Falling
  • Blood Flow Restriction (BFR) Training Effects
  • Blood Flow Restriction and Low-Intensity Resistance Training
03

In context

Lead sponsor

Concordia University, Montreal is the lead sponsor of 21 studies on the registry; 6 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
60 Years and older
Sexes eligible
All
Accepts healthy volunteers
Yes

Inclusion criteria

  • Participants will be both male and female, aged 60 years or older. They must be willing to participate in two exercise sessions per week for 10 weeks held online. Participants must also be able to visit Loyola campus for pre-, mid- and post-intervention testing.

Exclusion criteria

Exclusion Criteria:

  • Exclusion criteria include chronic disease (with the exclusion of hypertension), use of steroidal drugs, blood clot or varicose veins, part-take in excessive physical activity (over 3-4 hours a week of moderate to high intensity training) and have scheduled vacation or absence in the ten-week period. The reason behind excluding seniors who part-take in excessive physical activity is because the classes will be low intensity. Due to the fact that participants will be healthy older adults without chronic conditions, a medical form from a physician will not be necessary.
05

Study design

Phase
Not applicable
Primary purpose
Prevention
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Single (Participant)
Enrollment
30 participants (estimated)

Study arms

  • Active comparator
    Control

    This group with undergo online low-intensity resistance training twice per week

    Other: Blood flow restrictions in combination with low-intensity resistance training

  • Experimental
    Blood flow restriction

    This group with undergo online low-intensity resistance training with blood flow restriction twice per week

    Other: Blood flow restrictions in combination with low-intensity resistance training

Interventions

  • OtherBlood flow restrictions in combination with low-intensity resistance training

    Blood flow restrictions in combination with low-intensity resistance training to test if an online intervention (telehealth) can improve functional capacity and balance in older adults

06

What researchers measure

Primary outcomes

  1. Functional capacity

    Time frame: From enrollment to the end of intervention at 10 weeks

Secondary outcomes

  1. Balance and posture

    Time frame: From enrollment to the end of intervention at 10 weeks

07

Study locations

1 site
  • Concordia University
    Montreal, Quebec H4B 1R6, Canada
08

References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Dec 9, 2024, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT06724393
Lead sponsor
Concordia University, Montreal
Responsible party
Andreas Bergdahl (Associate Professor, Concordia University, Montreal) — Principal investigator
First posted
Dec 9, 2024
Start date
May 1, 2024
Primary completion
Jun 2025 (estimated)
Completion
Sep 2025 (estimated)
Last update
Dec 9, 2024

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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