PEEP Titration and Lung Recruitment Potential Assessed by 3D EIT

Browse trials for

• Respiratory Insufficiency 1,650

Keywords

• ARDS
• EIT
• 3D-EIT

Respiratory Insufficiency

1,650 studies on the registry are indexed under Respiratory Insufficiency; 297 are open to participants now.

This study's planned enrollment of 50 is below the median of 100 across 546 observational studies indexed under Respiratory Insufficiency.

Lead sponsor

Peking Union Medical College Hospital is the lead sponsor of 1,115 studies on the registry; 463 are open to participants now.

Study population

Groups and cohorts

• lung recruitment potential assessed by 3D EIT in ARDS

  Diagnosis of ARDS was based on the Berlin definition, who have receivied mechanical ventilation. The enrolled patients received a lung recruitment potential assessment by 3D EIT( as the follwoing mentioned )

  Procedure: lung recruitment potential assessed by 3D EIT

• PEEP titration by 3D EIT for ARDS

  Diagnosis of ARDS was based on the Berlin definition, who have receivied mechanical ventilation. The enrolled patients received a lung PEEP tirtation by 3D EIT( as the follwoing mentioned )

  Procedure: PEEP titration by 3D eit

Interventions

• Procedurelung recruitment potential assessed by 3D EIT

  Patients were ventilated based on the ARDS-Net suggestions. The patients were kept at supine position. The lung recruitment potential assessed by 3D EIT was as follows: 1. All patients were under pressure control mode (driving pressure 12-15 cmH2O with a tidal volume of 6-8 ml/kg predicted body weight, respiration rate12-15 bpm). 2. PEEP was switched to a zero end-expiratory pressure (ZEEP) for 10 min, and FiO2 was titrated to obtain peripheral oxygen saturation (SpO2 ) \> 90%. 3. PEEP was stepwise increase from 0 to 15 cmH2O PEEP in steps of 5cm H2O every 3min.And 3D EIT was used to assess lung recruitment potential.

• ProcedurePEEP titration by 3D eit

  Patients were ventilated based on the ARDS-Net suggestions. The patients were kept at supine position. The PEEP titriatino by 3D EIT fwas as follows: 1. All patients were under pressure control mode (driving pressure 12-15 cmH2O with a tidal volume of 6-8 ml/kg predicted body weight, respiration rate12-15 bpm). 2. RM: PEEP was switched to a 21cmH2O for 2min, and FiO2 was titrated to obtain peripheral oxygen saturation (SpO2 ) ≥90%. 3. PEEP was stepwise decrease from 21 to 0 cmH2O PEEP in steps of 3cm H2O every 2min. 4. 3D EIT was used to monitor regional ventilation distribution during PEEP titration.

Primary outcomes

1. OD/CL and optimal PEEP monitored by EIT

   Monitoring the lung collapse and overdistension region by EIT at different PEEP levels. Measure the optimal PEEP level based on collapse and overdistension rate.

   Time frame: 5-10min

Secondary outcomes

1. ventilation distribution monitored by EIT

   Monitoring the lung ventilation distribution by EIT at different PEEP levels

   Time frame: 5-10min

2. GI monitored by EIT

   Global Inhomogeneity (GI) Index monitored by EIT at different PEEP levels

   Time frame: 5-10min

3. CoV monitored by EIT

   Center of ventilation (COV) monitored by EIT at different PEEP levels

   Time frame: 5-10min

4. V/Q monitored by EIT

   Ventilation and perfusion monitored by EIT at different PEEP levels. To evaluate the V/Q match, deadspace and shunt lung region.

   Time frame: 5-10min