An observational study in Pancreatic Cancer, Surgery and Diabetes Mellitus, sponsored by Shanghai Changzheng Hospital. Recruiting at 1 site in China. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2025-07-01.
Sponsored by Shanghai Changzheng Hospital · Observational
The goal of this observational study is to learn about post-surgery of pancreatic cancer diabetes mellitus.The main questions it aims to answer are:
The reasearchers will summarize the incident rates of glucose metabolic disorders (pre-diabetes and diabetes mellitus) during different surgical procedures to explore the association between alternations in endocrine and exdocrine secrectory function and all-round outcomes.
Investigators will prospectively collect data from patients with pancreatic cancer after surgery in participant centers.
3,235 studies on the registry are indexed under Pancreatic Neoplasms; 899 are open to participants now.
This study's planned enrollment of 150 is below the median of 200 across 620 observational studies indexed under Pancreatic Neoplasms.
Browse Pancreatic Neoplasms studies →Shanghai Changzheng Hospital is the lead sponsor of 125 studies on the registry; 60 are open to participants now.
Counted across the registry records on this site, refreshed daily.
patients with pancreatic cancer after pancreatic surgery
1. male or female Chinese subjects; 2. Age ≥ 18 years; 3. patients with pancreatic cancer who are proposed to undergo pancreatectomy by pancreaticobiliary surgery at our hospital; 4. those who voluntarily completed the Pancreatobiliary Surgery Cohort Study and signed the informed consent; 5. those who have completed and banked serum and pathological specimens at our hospital.
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Exclusion Criteria:
1. those with a previous history of comorbid diabetes mellitus or pre-diabetes mellitus, or preoperative HbA1C ≥ 6.0% or fasting blood glucose ≥ 6.1 mmol/l; 2. those with positive islet-associated antibodies 3. those with the presence of medications, endocrine disease exposures that can lead to a risk of secondary diabetes; 4. pregnant or nursing women; 5. Cognitive impairment or other reasons for failing to sign the informed consent form.
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All enrolled subjects completed dynamic blood glucose monitoring to obtain continuous peripheral blood glucose data.
Number of Participants Who developed glucose metabolic disorders(pre-diabetes and diabetes mellitus)
The diagnosis of glucose disorders should be made applying criteria of the American Diabetes Association.
Time frame: From enrollment to five years after the end of the surgery
Overall Survival
Time frame: From enrollment to five years after the end of the surgery
Disease-Free Survival
Time frame: From enrollment to five years after the end of the surgery
Plan to share: No
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Shanghai Changzheng Hospital