An observational study in Whole Body Imaging, Cancer and Genetic Predisposition, sponsored by Fondazione Policlinico Universitario Agostino Gemelli IRCCS. Not yet recruiting at 2 sites in Italy. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2024-08-01.
Sponsored by Fondazione Policlinico Universitario Agostino Gemelli IRCCS · Observational
Whole-body magnetic resonance imaging (WB-MRI) is a non-ionizing imaging method that can provide WB coverage using essential imaging contrasts with the possibility to include sequences focusing in specific body-regions as needed per case. WB-MRI is increasingly being used for the management of cancer patients, especially metastatic ones. An integral part of WB-MRI is becoming whole-body diffusion-weighted MRI (WB-DWI) which is a non-invasive tool used for staging and response evaluation in oncologic practice. WB-DWI is an inherently noisy technique, resulting in it accounting for more than 50% of the acquisition time of conventional whole-body MRI studies with overall duration at least 1-hour. Reducing acquisition times, without compromising image or diagnostic quality would facilitate the wider adoption of clinical WBDWI, reducing costs, and improving the patient experience
141 studies on the registry are indexed under Disease Susceptibility; 31 are open to participants now.
This study's planned enrollment of 120 is below the median of 200 across 84 observational studies indexed under Disease Susceptibility.
Browse Disease Susceptibility studies →Fondazione Policlinico Universitario Agostino Gemelli IRCCS is the lead sponsor of 920 studies on the registry; 529 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Oncologic patients (with multiple myeloma, lymphoma, melanoma and metastatic cancer, such as prostate, breast and gynecologic cancers. Another application of WB-MRI is the imaging of patients with certain cancer predisposition syndromes
Exclusion Criteria:
Application of specific sequences with the use of Enhanced Diffusion Software during Patient MRI
Radiologists' satisfaction of the quality of images
Radiologists' satisfaction of the quality of images after applying noise reduction methods, in terms of mean overall response rate ≥4 at the questionnaires' items
Time frame: 18 months
Diagnostic accuracy of the de-noised WB-MRI in detecting lesions
Comparison of diagnostic accuracy for lesion detection after applying noise reduction methods with that of standard reference imaging modalities,
Time frame: 18 months
Diagnostic accuracy of the de-noised WB-MRI in detecting staging metastatic oncologic patients.
Comparison of diagnostic accuracy for staging neoplasms according to the reference staging system with that of standard reference imaging modalities.
Time frame: 18 months
Plan to share: No
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This study is not yet recruiting, as verified in Jul 2024. You cannot join it, but the record below documents what was studied.
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Fondazione Policlinico Universitario Agostino Gemelli IRCCS