An interventional study of Esketamine and normal saline in Anxiety State and Esketamine, sponsored by Zhejiang Cancer Hospital. Completed at 1 site in China. Open to participants aged 18 Years to 70 Years. Per ClinicalTrials.gov, last updated 2025-09-16.
Sponsored by Zhejiang Cancer Hospital · Not applicable, Interventional, and Treatment
To evaluate whether esketamine can relieve anxiety in patients undergoing abdominal tumor surgery.
Hamilton anxiety Scale was used to screen patients with anxiety. Only patients with score ≥ 8 were enrolled. These patients were randomly assigned to the experimental group and control group.
All patients enrolled were evaluated with Hamilton anxiety Scale, PHQ-8 scale, QoR-15 Scale and Athens Insomnia Scale. After induction, sevoflurane and remifentanil were used to maintain anesthesia. The experimental group had esketamine while the control group had normal saline. Athens Insomnia Scale was used to assess the sleep status 1, 2, 3 days after surgery and 1 month after surgery. Hamilton anxiety Scale was used to evaluate the anxiety state of the patients 3 days after surgery and 1 month after surgery. PHQ-8 scale, QoR-15 Scale were collected 3 days after surgery and 1 month after surgery.
4,868 studies on the registry are indexed under Anxiety Disorders; 1,390 are open to participants now.
This study's enrollment of 185 is above the median of 80 across 4,174 interventional studies indexed under Anxiety Disorders.
Browse Anxiety Disorders studies →Zhejiang Cancer Hospital is the lead sponsor of 271 studies on the registry; 116 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Esketamine 0.2mg/kg was given slowly after intubation, and then 0.1mg/kg/h was pumped continuously until the end of the operation. Patients received sufentanil based patient-controlled intravenous analgesia (PCIA) within 72 hours postoperatively, with sufentanil combined with esketamine 1mg/kg in a PCIA device.
Drug: Esketamine
Same volume of normal saline was given slowly after intubation, and then pumped continuously until the end of the operation. Patients received sufentanil based patient-controlled intravenous analgesia (PCIA) within 72 hours postoperatively, without esketamine in the PCIA device.
Drug: normal saline
Esketamine 0.2mg/kg was pumped slowly after intubation, followed by 0.1mg/kg pumped until the end of the operation. In the PCIA pump, esketamine 1mg/kg was added to the sufentanil.
Also known as: Experimental group
Same volume of normal saline was pumped slowly after intubation, followed by the same volume of NS until the end of the operation. In the PCIA pump, only sufentanil was used.
Also known as: Control Group
Whether esketamine can reduce anxiety status in patients with anxiety
assessed by Hamilton anxiety scale. The score ranges from 0 to 56, while the higher score means a more anxious state.
Time frame: 1 day before surgery, 3 days after surgery, 1 month after surgery
To explore whether esketamine can improve sleep status
assessed by Athens Insomnia Scale. Athens Insomnia Scale ranges from o to 24, with a higher score means a worse sleep status.
Time frame: 1 day before surgery, 1,2 and 3 days after surgery, 1 month after surgery
To explore whether esketamine can improve life quality
assessed by QoR-15 (quality of recovery-15). The score ranges from 0 (bad quality) to 150 (good quality).
Time frame: 1 day before surgery, 3 days after surgery, 1 month after surgery
This study is completed, as verified in Sep 2025. You cannot join it, but the record below documents what was studied.
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Zhejiang Cancer Hospital