An interventional study of Voluntary in Healthy Patients, sponsored by Nantes University Hospital. Completed at 1 site in France. Open to participants aged 18 Years to 70 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-04-06.
Sponsored by Nantes University Hospital · Not applicable, Interventional, and Other
The role of the pulmonary microbiome in the pathophysiology of lung disease is becoming increasingly well understood. Studies on murine models have highlighted the immunomodulatory and antibacterial activity of certain commensal bacteria, such as S. mitis, and have led to an understanding of their potential therapeutic impact. The investigators will therefore couple their analyses of the respiratory microbiome with an in-depth analysis of mucosal immunity. In particular, they will characterize immune cell types and frequencies using high-dimensional (spectral) flow cytometry and single cell RNA-sequencing. Finally, they will study the mediators exchanged between the microbiome and the host using proteomic and metabolomic analyses of respiratory fluids.
Nantes University Hospital is the lead sponsor of 825 studies on the registry; 195 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Subjects undergoing scheduled surgery in the operating room at Nantes University Hospital, requiring general anesthesia with placement of an endotracheal intubation tube for invasive mechanical ventilation.
Other: Voluntary
Subjects undergoing scheduled surgery in the operating room at Nantes University Hospital, requiring general anesthesia with placement of an endotracheal intubation tube for invasive mechanical ventilation.
Atlas of host-microbiome interactions
Healthy respiratory metacluster
Time frame: 1 day
Correlations between bacterial species
To define the link between the patient and the bacterial transcriptional activities
Time frame: Day 1
Correlations between bacterial species
To define the link between the patient and the bacterial composition
Time frame: Day 1
Correlations between cell populations
To define the link between the patient and the transcriptional clusters of cell populations
Time frame: Day 1
Correlations between metabolite concentrations
To define the link between the patient and the metabolite concentrations
Time frame: Day 1
Correlations between protein concentrations
To define the link between the patient and the protein concentrations
Time frame: Day 1
Correlations between host-microbiome interactions and quality of life scales
To define the link between the patient and different scales (MOCA, EPICES, modified MRC, NYHA, EQ5D-5L, SWLS, SF-36, HADS and BPI
Time frame: Day 1
Plan to share: Undecided
No publications or documents are linked to this record.
This study is completed, as verified in Mar 2026. You cannot join it, but the record below documents what was studied.
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Nantes University Hospital