An observational study in Myopia Progression, sponsored by Beijing Tongren Hospital. Recruiting at 1 site in China. Open to participants aged 6 Years to 9 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2024-07-12.
Sponsored by Beijing Tongren Hospital · Observational
The trend of myopia in children and its low age is a major social and public health problem in China. More seriously, retinopathy associated with high myopia has become the number one cause of irreversible blinding eye disease in adults in some parts of China. Physiological hyperopia has a protective effect on preventing the onset of myopia, and is one of the strongest predictors of myopia on its own, which is significant in curbing myopia from occurring at a younger age and preventing the development of high myopia before adulthood. However, it is not yet known how the physiological hyperopia changes in childhood, the stage at which the critical inflection point occurs, which key factors lead to the rapid fading of the physiological hyperopia and progression to myopia, and the strength of its effect. In the early stage of the study, the research group established a prospective cohort of preschoolers based on natural population sampling, which included a total of 2109 preschoolers aged 3-6 years from 22 kindergartens in a district in Beijing, and completed a 2-year follow-up, obtaining exploratory results on the changing pattern of physiological hyperopia and key influencing factors in younger children. The group will add new samples to the existing whole cohort sampling cohort and adopt the design scheme of prospective nested case-control study to determine the changing trend of fading trajectory of physiological hyperopia in school-age children, key inflection points and key risk factors, so as to provide new techniques for the prevention and control of childhood myopia.
Beijing Tongren Hospital is the lead sponsor of 163 studies on the registry; 53 are open to participants now.
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The research group has already sampled 3-6 years old preschool children from 22 kindergartens in Haidian District, Beijing, and included them in the baseline cohort, which has been followed up continuously for 3 years. The research group will continue to add new samples to the existing cluster sampling cohort and reorganize the cohort of children aged 6-9 years old to conduct this study.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Group A is defined as those whose physiological hyperopia (sphere+1/2 cylinder) of at least - 0.5 diopters(D) in either eye.
Other: This study was observational with no intervention.
Group B is defined as whose physiological hyperopia exceeds 95% confidence interval for children of same age (Near Myopia).
Other: This study was observational with no intervention.
Group C is defined as whose physiological hyperopia exceeds 90% confidence interval for children of same age.
Other: This study was observational with no intervention.
This study was observational with no intervention.
myopia
Myopia in this study was defined as an equivalent spherical lens degree ( SER ) error (sphere+1/2 cylinder) of at least - 0.5 diopters(D) in either eye.
Time frame: 1 year
Myopia Prevalence
Myopia is defined as a spherical equivalent refractive (SER) (sphere + 1/2 cylinder) of at least -0.5 diopter (D) in either eye.
Time frame: 3 year
The change in ocular axis length
The change in ocular axis length was calculated by subtracting each year's measurement from the previous year's measurement.
Time frame: 3 year
The change in anterior chamber depth
Calculate the change in anterior chamber depth by subtracting each year's measurement from the previous year's measurement.
Time frame: 3 year
The change in corneal curvature
Calculate the change in corneal curvature by subtracting each year's measurement from the previous year's measurement.
Time frame: 3 year
The change in the ratio of axial length to corneal curvature
Calculate the change in the ratio of axial length to corneal curvature by subtracting each year's measurement from the previous year's measurement.
Time frame: 3 year
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