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CompletedNCT06483126Updated Sep 19, 2025

The Benefits of Nature for Mood and Cognition in Persons With and Without Parkinson's Disease

An observational study in Parkinson Disease, Mood and Cognition, sponsored by Boston University Charles River Campus. Completed at 1 site in United States. Open to participants aged 40 Years to 100 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2025-09-19.

Sponsored by Boston University Charles River Campus · Observational

Study type
Observational
Model
Case-only
Time perspective
Cross-sectional
Enrollment
97
Ages
40 Years to 100 Years
Sex
All
01

Study summary

This online study aims to explore the benefits of nature for mood and cognition in persons with and without Parkinson's disease. For the purpose of this survey, "natural environment" refers to places that primarily consist of natural elements, such as vegetation, water bodies, and landscapes. This includes greenspaces (such as parks, gardens, neighborhood streets lined with trees, forests, or nature reserves) bluespaces (such as next to beaches, lakes, rivers, ponds, or waterfronts), and desert regions, among others.

Read the detailed description

To participate in this online study, you will need an email address, and a smartphone or laptop/desktop with internet access. If you are eligible to participate, you will be sent a link to an online survey (Qualtrics). We will ask questions about demographic and health information, followed by questions about exercise habits, exposure to natural environments (including greenspaces and bluespaces, among others), and questionnaires assessing mood, motivation, cognition, sleep, stress, quality of life, and related functions. The survey should take roughly 20-25 minutes to complete. This is an observational study only, and not an interventional study.

Compensation: A $15 Amazon gift card will be offered to those who complete the survey all the way through with good effort.

02

Conditions studied

  • Parkinson Disease
  • Mood
  • Cognition

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Keywords

  • Nature
  • Natural Environments
03

In context

Parkinson Disease

4,487 studies on the registry are indexed under Parkinson Disease; 1,082 are open to participants now.

This study's enrollment of 97 is close to the median of 96 across 1,057 observational studies indexed under Parkinson Disease.

Browse Parkinson Disease studies →

Lead sponsor

Boston University Charles River Campus is the lead sponsor of 154 studies on the registry; 30 are open to participants now.

Of its 14 completed or terminated interventional studies of FDA-regulated products, 8 (57%) have results posted.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
40 Years to 100 Years
Sexes eligible
All
Accepts healthy volunteers
Yes
Sampling method
Non-probability sample

Study population

Persons with and without Parkinson's disease volunteering for an online study

Inclusion criteria

For persons with Parkinson's disease:

  • Participants must be at least 40 years old
  • Have a diagnosis of idiopathic PD
  • Be proficient English speakers
  • Have functional vision
  • Have internet access, and access to a smartphone/laptop/desktop

For persons without Parkinson's disease:

  • Participants must be healthy middle-aged and older adults, with no diagnosis of neurological/neurodegenerative conditions
  • Participants must be at least 40 years old
  • Be proficient English speakers
  • Have functional vision
  • Have internet access, and access to a smartphone/laptop/desktop

Exclusion criteria

Exclusion Criteria (both groups):

  • Diagnosis of dementia
  • Poor vision (non-functional range)
  • Lack of access to internet or to a smartphone/ laptop/desktop computer.
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Study design

Observational model
Case-only
Time perspective
Cross-sectional
Enrollment
97 participants (actual)
Patient registry
No

Groups and cohorts

  • Persons with Parkinson's disease (PwPD)

    Individuals with a diagnosis of Parkinson's disease

  • Persons without Parkinson's disease

    Healthy middle-aged and older adults

06

What researchers measure

Primary outcomes

  1. Nature Connection Index

    Assesses the extent to which people feel connected to nature.

    Time frame: Baseline

  2. Perceived Restorativeness Scale

    Assesses the extent to which particular environments have restorative qualities. Higher scores indicate greater perceived restorativeness.

    Time frame: Baseline

  3. Center for Epidemiological Studies Depression (CES-D)

    Assesses depressive symptoms in the general population. Maximum score:60. Higher scores indicate more severe depression.

    Time frame: Baseline

  4. Parkinson's Disease Sleep Scale-2

    Assesses sleep and nocturnal disturbances in Parkinson's disease. Maximum score: 60. Higher scores indicate more frequent sleep disturbances.

    Time frame: Baseline

  5. Parkinson's Disease Questionnaire - 8 (PDQ-8)

    Assesses Parkinson's disease-specific health-related quality of life. Maximum Score: 32. Higher scores indicate worse quality of life.

    Time frame: Baseline

  6. Perceived Stress Scale

    Assesses how different situations affect feelings and perception of stress. Maximum score: 40. Higher scores indicate higher perceived stress.

    Time frame: Baseline

  7. NIH NeuroQoL measures

    Assesses health-related quality of life in adults with neurological disorders. Higher scores on the sub-scales indicate worse outcomes.

    Time frame: Baseline

  8. Parkinson's Anxiety Scale (PAS)

    Assesses the severity of anxiety symptoms in persons with Parkinson's disease. Maximum score:48. Higher scores indicate more severe anxiety.

    Time frame: Baseline

07

Study locations

1 site
  • Vision and Cognition Laboratory, Boston University
    Boston, Massachusetts 02215, United States
08

References and documents

Publications

  • Alcock I, White MP, Wheeler BW, Fleming LE, Depledge MH. Longitudinal effects on mental health of moving to greener and less green urban areas. Environ Sci Technol. 2014 Jan 21;48(2):1247-55. doi: 10.1021/es403688w. Epub 2014 Jan 7. PubMed 24320055 ↗
  • Gascon M, Triguero-Mas M, Martinez D, Dadvand P, Forns J, Plasencia A, Nieuwenhuijsen MJ. Mental health benefits of long-term exposure to residential green and blue spaces: a systematic review. Int J Environ Res Public Health. 2015 Apr 22;12(4):4354-79. doi: 10.3390/ijerph120404354. PubMed 25913182 ↗
  • Hartig T, Mitchell R, de Vries S, Frumkin H. Nature and health. Annu Rev Public Health. 2014;35:207-28. doi: 10.1146/annurev-publhealth-032013-182443. Epub 2014 Jan 2. PubMed 24387090 ↗
  • Rigolon A, Browning MHEM, McAnirlin O, Yoon HV. Green Space and Health Equity: A Systematic Review on the Potential of Green Space to Reduce Health Disparities. Int J Environ Res Public Health. 2021 Mar 4;18(5):2563. doi: 10.3390/ijerph18052563. PubMed 33806546 ↗
  • Rodriguez-Loureiro L, Casas L, Bauwelinck M, Lefebvre W, Vanpoucke C, Vanroelen C, Gadeyne S. Social inequalities in the associations between urban green spaces, self-perceived health and mortality in Brussels: Results from a census-based cohort study. Health Place. 2021 Jul;70:102603. doi: 10.1016/j.healthplace.2021.102603. Epub 2021 Jun 21. PubMed 34166885 ↗
  • Miller IN, Neargarder S, Risi MM, Cronin-Golomb A. Frontal and posterior subtypes of neuropsychological deficit in Parkinson's disease. Behav Neurosci. 2013 Apr;127(2):175-183. doi: 10.1037/a0031357. Epub 2013 Feb 11. PubMed 23398433 ↗
  • Cerin E, Barnett A, Shaw JE, Martino E, Knibbs LD, Tham R, Wheeler AJ, Anstey KJ. From urban neighbourhood environments to cognitive health: a cross-sectional analysis of the role of physical activity and sedentary behaviours. BMC Public Health. 2021 Dec 23;21(1):2320. doi: 10.1186/s12889-021-12375-3. PubMed 34949175 ↗
  • Cerin E, Barnett A, Shaw JE, Martino E, Knibbs LD, Tham R, Wheeler AJ, Anstey KJ. Urban Neighbourhood Environments, Cardiometabolic Health and Cognitive Function: A National Cross-Sectional Study of Middle-Aged and Older Adults in Australia. Toxics. 2022 Jan 7;10(1):23. doi: 10.3390/toxics10010023. PubMed 35051065 ↗

Individual participant data

Plan to share: No

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Sep 19, 2025, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT06483126
Lead sponsor
Boston University Charles River Campus
Responsible party
Alice Cronin-Golomb (Director, Vision and Cognition Laboratory, Boston University Charles River Campus) — Principal investigator
First posted
Jul 3, 2024
Start date
Aug 12, 2024
Primary completion
Jul 31, 2025
Completion
Jul 31, 2025
Last update
Sep 19, 2025

Study contacts

Alice Cronin-Golomb, PhD
principal investigator · Boston University

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Aug 2024. You cannot join it, but the record below documents what was studied.

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