An interventional study of Low protein diet with AC-134 and Standard treatment in Nephrology, sponsored by Taichung Veterans General Hospital. Completed at 2 sites in Taiwan. Open to participants aged 20 Years to 90 Years. Per ClinicalTrials.gov, last updated 2026-06-12.
Sponsored by Taichung Veterans General Hospital · Not applicable, Interventional, and Other
The objective is to explore the effects of adding AC-134 on renal function, proteinuria, uremic toxins, and metabolism-related markers in chronic kidney disease.
Chronic kidney disease (CKD) management primarily focuses on addressing associated complications such as hypertension, diabetes mellitus, cardiovascular disease, and proteinuria. In addition to standard therapies, reducing the accumulation of toxins, particularly gut-derived uremic toxins like indoxyl sulfate (IS) and p-cresol sulfate (PCS), may help alleviate uremia symptoms. This study assesses the impact of oral AC-134 capsules containing activated charcoal adsorbent on CKD patients. The assessment will include evaluating changes in renal function, proteinuria, uremic toxins, and metabolism-related markers.
3,090 studies on the registry are indexed under Renal Insufficiency, Chronic; 698 are open to participants now.
This study's enrollment of 100 is above the median of 73 across 2,157 interventional studies indexed under Renal Insufficiency, Chronic.
Browse Renal Insufficiency, Chronic studies →Taichung Veterans General Hospital is the lead sponsor of 175 studies on the registry; 39 are open to participants now.
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Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Malignancy means cancer. Criteria about another or earlier malignancy ask whether you have had a different cancer, usually within a set number of years.
Some are commonly allowed, such as treated skin cancers other than melanoma and early cancers removed completely — check the exceptions this study lists.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Cancer (malignancy)
Malignancy means cancer. Criteria about another or earlier malignancy ask whether you have had a different cancer, usually within a set number of years.
Some are commonly allowed, such as treated skin cancers other than melanoma and early cancers removed completely — check the exceptions this study lists.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Low-protein diet strategies combined with AC-134 capsules
Dietary Supplement: Low protein diet with AC-134
Low-protein diet strategies
Other: Standard treatment
Low protein diet combined with AC-134 Dosage: 2 capsules,three times/day
Low protein diet
Estimated glomerular filtration rate (eGFR) measurement
The eGFR level is a maker for kidney function
Time frame: Baseline to 3 months
Blood Urea Nitrogen (BUN) levels
Blood Urea Nitrogen
Time frame: Baseline to 3 months
Uremic toxins assay
The concentration of p-cresol sulfate level, indoxyl sulfates level, and acrolein in the subjects' blood samples
Time frame: Baseline to 3 months
Liver function
The concentration of ALT, AST, total bilirubin and direct bilirubin in the subjects' blood samples
Time frame: Baseline to 3 months
Inflammation makers
The concentration of inflammation makers in the subjects' blood samples
Time frame: Baseline to 3 months
Nutrition status
The concentration of albumin, wbc and uric acid in the subjects' blood samples
Time frame: Baseline to 3 months
Lipid analysis
The concentration of total cholesterol , triglyceride , HDL-cholesterol and LDL-cholesterol in the subjects' blood samples
Time frame: Baseline to 3 months
Sugar test
The concentration of fasting sugar and HbA1C in the subjects' blood samples
Time frame: Baseline to 3 months
The quality of life
It will measure by the Kidney Disease Quality of Life (\[KDQOL\]-SF™) questionnaire
Time frame: Baseline to 3 months
Anemia test
The concentration of hemoglobin (Hb) in the subject's blood samples
Time frame: Baseline to 3 months
Urine protein analysis
Urine specimen collection will be evaluated on the spot and 24-hour urine protein
Time frame: Baseline to 3 months
24-hour Dietary recall
There will be collected by food models or a photography atlas to estimate portion size
Time frame: Baseline to 3 months
Gastrointestinal symptoms measures
There will be collected by questionnaires symptoms or chief complaints
Time frame: Baseline to 3 months
Grip strength levels
Hand grip strength was measured by grip strength device
Time frame: Baseline to 3 months
Blood gas
The concentration of blood gas test in the subject's blood samples
Time frame: Baseline to 3 months
Electrolytes Analysis
The concentration of electrolytes analysis in the subject's blood samples
Time frame: Baseline to 3 months
Mitochondrial oxidative stress
The concentration analysis in the subject's blood or urine samples, such as MDA
Time frame: Baseline to 3 months
This study is completed, as verified in Jun 2026. You cannot join it, but the record below documents what was studied.
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Renal Insufficiency, Chronic →
Taichung Veterans General Hospital →