An observational study in Cesarean Section Complications, Postpartum Hemorrhage and Morbidity;Perinatal, sponsored by Mahidol University. Completed at 1 site in Thailand. Open to female participants. Per ClinicalTrials.gov, last updated 2025-10-02.
Sponsored by Mahidol University · Observational
The objective of this study is to examine the predictive capability of the Obstetric comorbidity index in the identification of severe maternal morbidity associated with postpartum hemorrhage in patients undergoing cesarean delivery.
The prospectively predictive maternal morbidity is imperative to enhance maternal outcomes. There has been development of the obstetric comorbidity index (OBCMI) by Bateman et al. in 2013 and performed with superior performance characteristics relative to general comorbidity measures in an obstetric population. The score has been a growing recognition of the necessity for specialized risk assessment tools tailored specifically to obstetric populations that differ from other populations. For instance, both the Charlson/Romano comorbidity index or the Elixhauser comorbidity score and their adaptations are deficient in accounting for obstetric conditions, thereby limiting their ability to predict obstetric morbidity or mortality.
The Obstetric Comorbidity Index has undergone thorough examination and validation across multiple nations. These findings collectively demonstrate the index's capacity for moderate to high predictive accuracy in anticipating maternal morbidities, accompanied by a commendable discriminative performance.
However, within the context of Thailand, investigations concerning the Obstetric Comorbidity Index and its association with perioperative complications or morbidities in postpartum hemorrhage patients undergoing cesarean delivery remain unexplored. Therefore, this study aims to elucidate the correlation between the Obstetric Comorbidity Index and severe maternal morbidity, while also scrutinizing the prevalence of comorbidities during the perioperative period among patients undergoing cesarean delivery at the largest University hospital, in THAILAND. Predicting the rate of maternal morbidity would be advantageous for facilitating preparation and augmenting awareness of complications during the perioperative period.
445 studies on the registry are indexed under Postpartum Hemorrhage; 75 are open to participants now.
This study's enrollment of 583 is above the median of 150 across 91 observational studies indexed under Postpartum Hemorrhage.
Browse Postpartum Hemorrhage studies →Mahidol University is the lead sponsor of 730 studies on the registry; 118 are open to participants now.
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The chart of patients who underwent cesarean delivery with the diagnosis of postpartum hemorrhage (bleeding >, = 1,000 ml) and gestational age of more than 24 weeks.
The patients underwent cesarean delivery with the diagnosis of postpartum hemorrhage (ICD-10 coding O72.1)
Exclusion Criteria:
Patients with either one of severe maternal morbidity (severe hemorrhage, hypertension/neurologic, renal, sepsis, pulmonary, cardiac, intensive care unit, and anesthesia complications)
Other: Obstetric comorbidity index
Patients without the severe maternal morbidity conditions
Other: Obstetric comorbidity index
Obstetric comorbidity index score
The prediction of severe maternal morbidity using obstetric comorbidity index
The prediction of severe maternal morbidity using obstetric comorbidity index presented in C-statistic (AUC of ROC)
Time frame: in 72 hours after cesarean delivery
Rate of blood transfusion
Perioperative red blood cells transfusion in units
Time frame: in 72 hours after cesarean delivery
Quantity of postpartum hemorrhage
Quantity of postpartum hemorrhage in ml.
Time frame: in 24 hours after cesarean delivery
Cause of postpartum hemorrhage
Main cause of postpartum hemorrhage
Time frame: in 24 hours after cesarean delivery
Rate of ICU admission
Rate of intensive care unit admission
Time frame: in 24 hours after cesarean delivery
Rate of Postoperative complications
Post operative complications eg. congestive heart failure, TRALI, acute kidney injury
Time frame: in 72 hours after cesarean delivery
Neonatal Apgar score
Neonatal Apgar score from 0 - 10
Time frame: at 1-minute and 5-minute after delivery
Rate of maternal mortality
Maternal death rate
Time frame: in 72 hours after cesarean delivery
Plan to share: No — The investigators may balance the potential benefits and risks for each request and then provide the data that could be shared, together with the permission from the hospital director.
No publications or documents are linked to this record.
This study is completed, as verified in Sep 2025. You cannot join it, but the record below documents what was studied.
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