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RecruitingNCT06430346Updated Dec 4, 2025

Exercise Prehabilitation for Locoregional Esophageal Cancer

An interventional study of Exercise in Esophageal Cancer, sponsored by H. Lee Moffitt Cancer Center and Research Institute. Recruiting at 1 site in United States. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2025-12-04.

Sponsored by H. Lee Moffitt Cancer Center and Research Institute · Not applicable, Interventional, and Supportive care

From the registry’s dates

  • Started May 2024; still recruiting 2 years 4 months later.
Phase
Not applicable
Study type
Interventional
Enrollment
20
Allocation
Not applicable
Ages
18 Years and older
Sex
All
01

Study summary

The purpose of the study is to examine the feasibility and acceptability of exercise "prehabilitation" for patients preparing for esophageal cancer resection (removal).

02

Conditions studied

  • Esophageal Cancer
03

In context

Esophageal Neoplasms

1,593 studies on the registry are indexed under Esophageal Neoplasms; 461 are open to participants now.

This study's planned enrollment of 20 is below the median of 58 across 1,171 interventional studies indexed under Esophageal Neoplasms.

Browse Esophageal Neoplasms studies →

Lead sponsor

H. Lee Moffitt Cancer Center and Research Institute is the lead sponsor of 533 studies on the registry; 74 are open to participants now.

Of its 99 completed or terminated interventional studies of FDA-regulated products, 57 (58%) have results posted.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • Biopsy-proven locoregional esophageal cancer (LEC)
  • Eastern Cooperative Oncology Group (ECOG) performance status 0-2
  • Treatment plan including neoadjuvant chemoradiation therapy and surgical resection
  • Ability to read and speak English

Exclusion criteria

Exclusion Criteria:

  • Regular engagement in resistance training (2x/week targeting all major muscle groups)
  • Screen failure for exercise safety based on PAR-Q
  • Underlying unstable cardiac or pulmonary disease or symptomatic cardiac disease
  • Recent fracture or acute musculoskeletal injury that precludes ability to participate in resistance training safely
  • Numeric pain rating scale of 7 or more out of 10
  • Myopathic or rheumatologic disease that impacts physical function
05

Study design

Phase
Not applicable
Primary purpose
Supportive care
Allocation
Not applicable
Intervention model
Single group
Masking
None (open label)
Enrollment
20 participants (estimated)

Study arms

  • Experimental
    Exercise prehabilitation

    In this trial participants will participate in an exercise program for 5 to 17 weeks, varying with treatment plans. Participants will receive resistance training equipment and participate in resistance training sessions twice per week (approximately 30-45 minutes per session). A Fitbit device will be provided to monitor step counts.

    Behavioral: Exercise

Interventions

  • BehavioralExercise

    Physical activity and resistance training

06

What researchers measure

Primary outcomes

  1. Retention

    The number of participants who complete T0 and T1 measures.

    Time frame: Up to 11 weeks

Secondary outcomes

  1. Exploratory outcomes and changes

    The number of participants who demonstrate improvements in exploratory outcome measures.

    Time frame: Up to 17 weeks

  2. Clinical and treatment outcomes

    Chi-square testing will be used to determine if there's a difference in perioperative outcomes between groups.

    Time frame: Up to 17 weeks

07

Study locations

1 of 1 sites recruiting
  • Moffitt Cancer Center
    Tampa, Florida 33612, United States
    • Nathan Parker, PhD · Contact · Nathan.Parker@moffitt.org · 813-745-0527
    • Nathan Parker, PhD · Principal investigator
    • Jose Pimiento, MD · Principal investigator
    Recruiting
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Dec 4, 2025, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT06430346
Lead sponsor
H. Lee Moffitt Cancer Center and Research Institute
Responsible party
Sponsor
First posted
May 28, 2024
Start date
May 21, 2024
Primary completion
May 2027 (estimated)
Completion
May 2027 (estimated)
Last update
Dec 4, 2025

Study contacts

Nathan Parker, PhD
Contact
Nathan.Parker@moffitt.org
813-745-6849
Nathan Parker, PhD
principal investigator · Moffitt Cancer Center

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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