CClinicalTrials.gg
Active, not recruitingNCT06429748SETUpdated Jun 29, 2026

Symptom Evaluation Following Repetitive Transcranial Magnetic Stimulation

An interventional study of rTMS in Neurologic Symptoms, sponsored by Neuronetics. Active, not recruiting at 1 site in United States. Open to participants aged 22 Years to 70 Years. Per ClinicalTrials.gov, last updated 2026-06-29.

Sponsored by Neuronetics · Not applicable, Interventional, and Treatment

Phase
Not applicable
Study type
Interventional
Enrollment
20
Allocation
Not applicable
Ages
22 Years to 70 Years
Sex
All
01

Study summary

A prospective study to evaluate symptoms following repetitive transcranial Magnetic stimulation.

Read the detailed description

Open-label, multicenter, prospective pilot study conducted in an adult population receiving rTMS treatment.

02

Conditions studied

  • Neurologic Symptoms
03

In context

Neurologic Manifestations

198 studies on the registry are indexed under Neurologic Manifestations; 67 are open to participants now.

This study's enrollment of 20 is below the median of 40 across 107 interventional studies indexed under Neurologic Manifestations.

Browse Neurologic Manifestations studies →

Lead sponsor

Neuronetics is the lead sponsor of 13 studies on the registry; 2 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
22 Years to 70 Years
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  1. Adults, 22 to 70 years of age
  2. Voluntarily provides written informed consent and agree to comply with study procedures, including attending all study visits and completing all study assessments.
  3. Score > or = 8 on ISI scale
  4. If subject is on any psychiatric or sleep medication, dose must be stable for two weeks prior to enrollment and remain stable throughout the trial.
  5. If female, not breastfeeding, no known or suspected pregnancy, a status of nonchildbearing potential or use of an acceptable form of birth control.
  6. Subject on stable dose regime for other concurrent medications like hormonal therapy for menopause transition etc.

Exclusion criteria

Exclusion Criteria:

  1. Subject meets any one or more of the contraindications for TMS Therapy per current treatment guidelines as determined by the PI.
  2. History of head trauma associated with loss of consciousness or diagnosed as concussion.
  3. History of fainting, syncope, hearing problems or ringing in the ears (tinnitus)
  4. Has any metallic implant(s) in or near the head (e.g., pacemaker, defibrillator, neurostimulator, etc.) including any splinters, fragments, clips, etc.
  5. Has an implanted stimulator device (including device leads) in or near the head. (e.g. deep brain stimulator, cochlear implant, vagus nerve stimulator.)
  6. Has medication infusion device.
  7. Subjects with any prior TMS or MRI complications, or any other issues/circumstance which, in the opinion of the investigator, might interfere with safety, study participation, or which might confound data interpretation.
  8. PHQ-9 total score > or = 10 or QIDS total score > or = 11.
  9. Drug abuse or dependence of the illicit substance. (Abuse or Dependence, as defined by DSM-V-TR)
  10. Current diagnosis or known history of neurologic disease (e.g., epilepsy, convulsion, seizure)
  11. Other known disorder (e.g., narcolepsy, a breathing-related sleep disorder like Obstructive Sleep Apnea, a circadian rhythm sleep-wake disorder, a parasomnia) as defined by DSM-V-TR.
  12. Has a clinically significant abnormality on the screening examination.
  13. Participation in any clinical trial with an investigational drug or device within the past month or concurrent with study participation.
05

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Not applicable
Intervention model
Single group
Masking
None (open label)
Enrollment
20 participants (actual)

Study arms

  • Experimental
    Open Label

    Single Group

    Device: rTMS

Interventions

  • DevicerTMS

    repetitive Transcranial Magnetic Stimultion

06

What researchers measure

Primary outcomes

  1. Changes in multiple symptoms after rTMS treatment.

    Assess changes in multiple symptoms scores based on patient reported questionnaires from baseline to end of acute.

    Time frame: 4 weeks

Secondary outcomes

  1. Durability of changes in symptoms

    Assess changes in multiple symptoms scores based on patient reported questionnaires from baseline to final follow-up visit.

    Time frame: 16 weeks

Other outcomes

  1. Safety Outcome

    Treatment related Adverse Events

    Time frame: 16 weeks

07

Study locations

1 site
  • Charlotte Skin and Laser
    Charlotte, North Carolina 28207, United States
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jun 29, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT06429748
Lead sponsor
Neuronetics
Responsible party
Sponsor
First posted
May 28, 2024
Start date
May 15, 2024
Primary completion
Apr 29, 2025
Completion
Dec 30, 2027 (estimated)
Last update
Jun 29, 2026

Study contacts

Steve Erickson
study director · Neuronetics

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
Yes
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is active, not recruiting, as verified in Jun 2026. You cannot join it, but the record below documents what was studied.

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