An observational study in BRCA1/2 Mutation and Breast-conserving Surgery, sponsored by Hanyang University Seoul Hospital. Completed at 1 site in Korea, Republic of. Open to female participants aged 20 Years to 80 Years. Per ClinicalTrials.gov, last updated 2024-05-28.
Sponsored by Hanyang University Seoul Hospital · Observational
The investigators matched BCS and mastectomy group using propensity scores and analyzed the recurrence and survival among the evenly matched patients in breast cancer patients with BRCA 1/2 mutations.
The purpose of study is to assess the oncologic safety of BCS in patients carrying BRCA1/2 mutations by comparing long-term outcomes with mastectomy. The investigators matched BCS and mastectomy group using propensity scores and analyzed the recurrence and survival among the evenly matched patients. By providing insights into the feasibility of BCS for patients with BRCA1/2 mutations, the investigators aim to present evidence to aid in surgical decision-making for the care of these patients.
Hanyang University Seoul Hospital is the lead sponsor of 26 studies on the registry; 5 are open to participants now.
Counted across the registry records on this site, refreshed daily.
The ON-BRCAII is multi-institution cohort study being conducted by the Korea Robot-Endoscopy Minimal Access Breast Surgery Study Group (KoREa-BSG). Patients with primary breast cancer who underwent BCS or mastectomy and received a BRCA1/2 mutation test between January 2008 and December 2015 were retrospectively identified from 13 institutions in South Korea. The inclusion criteria comprised patients aged 20 to 80 years with invasive breast cancer (pT1-3, N0-3). The exclusion criteria consisted of patients with de novo metastasis and those with pregnancy-associated breast cancer.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Cancer that has spread from where it began to other parts of the body. “Metastatic” cancer is cancer that has spread this way.
Metastases
Cancer that has spread from where it began to other parts of the body. “Metastatic” cancer is cancer that has spread this way.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Department of Surgery, Dongtan Sacred Heart Hospital, Hallym University, Dongtan, Republic of Korea
Procedure: Breast-conserving surgery
Division of Breast Surgery, Department of Surgery, Sungkyunkwan University School of Medicine, Samsung Medical Center, Seoul, Republic of Korea
Procedure: Breast-conserving surgery
Breast Care Center, Department of Surgery, Seoul National University Hospital, Seoul, Republic of Korea
Procedure: Breast-conserving surgery
Department of Surgery, Severance hospital, Yonsei University College of Medicine, Seoul, Republic of Korea
Procedure: Breast-conserving surgery
Department of Surgery, School of Medicine, Kyungpook National University, Kyungpook National University Chilgok Hospital, Daegu, Republic of Korea
Procedure: Breast-conserving surgery
Department of Surgery, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea
Procedure: Breast-conserving surgery
Department of Surgery, Hanyang University Medical Center, Hanyang University College of Medicine, Seoul, Republic of Korea
Procedure: Breast-conserving surgery
Department of Breast \& Endocrine Surgery, Hallym University Sacred Heart Hospital, Hallym University, Anyang, Republic of Korea
Procedure: Breast-conserving surgery
Department of Surgery, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
Procedure: Breast-conserving surgery
Department of Surgery, Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Incheon, Republic of Korea
Procedure: Breast-conserving surgery
Department of Surgery, Kyung Hee University Hospital, Seoul, Republic of Korea
Procedure: Breast-conserving surgery
Department of Surgery, Keimyung University School of Medicine, Daegu, Republic of Korea
Procedure: Breast-conserving surgery
Division of Breast Surgery, Department of Surgery, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea
Procedure: Breast-conserving surgery
Breast-conserving surgery, also known as breast-conserving therapy or lumpectomy, is a surgical procedure used to treat breast cancer while preserving as much of the breast tissue as possible. During this procedure, the surgeon removes the cancerous tumor along with a surrounding margin of normal tissue. The goal is to remove the cancerous cells while maintaining the appearance and function of the breast as much as possible.
Locoregional recurrence-free survival
Recurrence in breast or chest wall and/or regional lymph nodes
Time frame: Duration from diagnosis until the development of recurrence up to 10year
Distant recurrence-free survival
Recurrence in a distant organ
Time frame: Duration from diagnosis until the development of recurrence up to 10year
Recurrence-free survival
Any form of disease recurrence
Time frame: Duration from diagnosis until the development of recurrence up to 10year
Ran from Jul 2022 to primary completion in Dec 2023, 17 months.
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This study is completed, as verified in Apr 2024. You cannot join it, but the record below documents what was studied.
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Hanyang University Seoul Hospital