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CompletedNCT06396351Updated May 2, 2024

Factors Affecting Abdominal Compliance During CO2 Insufflation in Laparoscopic Abdominal Surgery

An observational study in Laparoscopic Surgery, sponsored by Ankara University. Completed at 1 site in Turkey (Türkiye). Open to participants aged 18 Years to 82 Years. Per ClinicalTrials.gov, last updated 2024-05-02.

Sponsored by Ankara University · Observational

Study type
Observational
Model
Other
Time perspective
Prospective
Enrollment
90
Ages
18 Years to 82 Years
Sex
All
01

Study summary

The authors aimed to evaluate factors influencing abdominal compliance in laparoscopic abdominal surgery.

Read the detailed description

During laparoscopic surgery, pneumoperitoneum is achieved by insufflating carbon dioxide (CO2) gas into the abdominal cavity to create a safe working space. Pneumoperitoneum-induced elevation in intra-abdominal pressure (IAP) can result in various complications. Abdominal compliance (AC), represents the slope of the P-V curve of the abdominal cavity and is a measure of the ease of abdominal dilatation, is important to balance between surgical safety and complications. The aim of this study was to determine the effect of demographic and anatomic variables on AC.

The study included 90 patients who underwent laparoscopic abdominal surgery. Subcutaneous adipose tissue and abdominal muscle thickness were measured ultrasonographically. Mean AC was calculated during insufflation using the formula (ΔV/ΔP). The relationship between demographic and anatomic variables and AC was investigated

02

Conditions studied

  • Laparoscopic Surgery

Keywords

  • abdominal compliance
  • intraabdominal pressure
  • laparoscopic surgery
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In context

Lead sponsor

Ankara University is the lead sponsor of 318 studies on the registry; 65 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 82 Years
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

ASA I-III patients aged between 18 and 82 years undergoing elective abdominal surgery with laparoscopic technique.

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

Aged between 18 and 82 years ASA class I-III Elective abdominal surgery with laparoscopic technique

-

Exclusion criteria

Exclusion Criteria:

Aged below 18 and above 82 ASA IV-V

05

Study design

Observational model
Other
Time perspective
Prospective
Enrollment
90 participants (actual)
Patient registry
No

Interventions

  • ProcedureLaparoscopic surgery

    effect of carbondioxide insufflation on abdominal compliance was evaluated

    Also known as: Carbondioxide insufflation

06

What researchers measure

Primary outcomes

  1. The factors affecting abdominal compliance

    Effect of rectus muscle thickness and lateral abdominal muscle group thickness on abdominal compliance. Abdominal compliance is calculated by dividing intrabdominal volume change to intraabdominal pressure change during abdominal carbondioxide insufflation.

    Time frame: From the beginning of carbondioxide insufflation to the intraabdominal pressure of 15 mmHg during surgery

Secondary outcomes

  1. The factors affecting abdominal compliance

    Time frame: From the beginning of carbondioxide insufflation to the intraabdominal pressure of 15 mmHg during surgery

  2. The factors affecting abdominal compliance

    Effect of age on abdominal compliance. Abdominal compliance is calculated by dividing intrabdominal volume change to intraabdominal pressure change during abdominal carbondioxide insufflation.

    Time frame: From the beginning of carbondioxide insufflation to the intraabdominal pressure of 15 mmHg during surgery

  3. The factors affecting abdominal compliance

    Effect of gender on abdominal compliance. Abdominal compliance is calculated by dividing intrabdominal volume change to intraabdominal pressure change during abdominal carbondioxide insufflation.

    Time frame: From the beginning of carbondioxide insufflation to the intraabdominal pressure of 15 mmHg during surgery

  4. The factors affecting abdominal compliance

    Effect of ASA physical status on abdominal compliance. Abdominal compliance is calculated by dividing intrabdominal volume change to intraabdominal pressure change during abdominal carbondioxide insufflation.

    Time frame: From the beginning of carbondioxide insufflation to the intraabdominal pressure of 15 mmHg during surgery

  5. The factors affecting abdominal compliance

    Effect of body mass index on abdominal compliance. Abdominal compliance is calculated by dividing intrabdominal volume change to intraabdominal pressure change during abdominal carbondioxide insufflation.

    Time frame: From the beginning of carbondioxide insufflation to the intraabdominal pressure of 15 mmHg during surgery

  6. The factors affecting abdominal compliance

    Effect of previous surgery on abdominal compliance. Abdominal compliance is calculated by dividing intrabdominal volume change to intraabdominal pressure change during abdominal carbondioxide insufflation.

    Time frame: From the beginning of carbondioxide insufflation to the intraabdominal pressure of 15 mmHg during surgery

  7. The factors affecting abdominal compliance

    Effect of pregnancy on abdominal compliance. Abdominal compliance is calculated by dividing intrabdominal volume change to intraabdominal pressure change during abdominal carbondioxide insufflation.

    Time frame: From the beginning of carbondioxide insufflation to the intraabdominal pressure of 15 mmHg during surgery

  8. The factors affecting abdominal compliance

    Effect of subcutaneous adipose tissue thickness on abdominal compliance. Abdominal compliance is calculated by dividing intrabdominal volume change to intraabdominal pressure change during abdominal carbondioxide insufflation.

    Time frame: From the beginning of carbondioxide insufflation to the intraabdominal pressure of 15 mmHg during surgery

07

Study locations

1 site
  • Ankara University Medical School Anesthesiology and ICU Department
    Ankara, Turkey (Türkiye)
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on May 2, 2024, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT06396351
Lead sponsor
Ankara University
Responsible party
Sanem Cakar Turhan (Associate professor, MD, Ankara University) — Principal investigator
First posted
May 2, 2024
Start date
Aug 1, 2022
Primary completion
Nov 30, 2022
Completion
Nov 30, 2022
Last update
May 2, 2024

Study contacts

Menekse Ozcelik
study chair · Ankara University
Ezgi Yıldırım
principal investigator · Ankara University
Keziban Sanem Çakar Turhan
study chair · Ankara University
Aysegul Guven
principal investigator · Ankara University
Derya Gökmen
principal investigator · Ankara University

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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