An interventional study of Diffusion Kurtosis Imaging (DKI) and Resting State Magnetoencephalography in Amyotrophic Lateral Sclerosis and Pseudobulbar Affect, sponsored by Aalborg University Hospital. Recruiting at 1 site in Denmark. Open to participants aged 18 Years to 90 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2025-01-29.
Sponsored by Aalborg University Hospital · Not applicable, Interventional, and Other
The investigators aim to elucidate characteristics of structural and functional brain connectivity in patients with amyotrophic lateral sclerosis (ALS) and pseudobulbar affect (PBA) using diffusion kurtosis imaging (DKI) and magnetoencephalography (MEG).
717 studies on the registry are indexed under Motor Neuron Disease; 137 are open to participants now.
This study's planned enrollment of 50 is above the median of 35 across 461 interventional studies indexed under Motor Neuron Disease.
Browse Motor Neuron Disease studies →Aalborg University Hospital is the lead sponsor of 195 studies on the registry; 39 are open to participants now.
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Exclusion Criteria:
Sex- and age matched, healthy control. Will only have baseline DKI and MEG performed.
Other: Diffusion Kurtosis Imaging (DKI) · Other: Resting State Magnetoencephalography
ALS patient without PBA, either at baseline and 6 month follow-up
Other: Diffusion Kurtosis Imaging (DKI) · Other: Resting State Magnetoencephalography
ALS patient with PBA, either at baseline or follow-up
Other: Diffusion Kurtosis Imaging (DKI) · Other: Resting State Magnetoencephalography
Non-invasive MRI sequence which extracts information of diffusion signals from complex brain tissue
Non-invasive method of measuring resting state brain activity through magnetoencephalography (MEG)
Mean kurtosis
A measurement of kurtosis diffusion signal in pseudobulbar affect-affiliated brains areas (prefrontal lobe, pons, cerebellum, motor cortex, temporal lobe) derived from Diffusion kurtosis imaging (DKI)-MRI
Time frame: Baseline measurement and up to 6 month follow-up measurements
Spectral connectivity
Estimation of connectivity (correlation between spikes of activity) between pseudobulbar affect afflilated cortical brain areas (prefrontal cortex, motor cortex, temporal lobe) derived through resting state magnetoencelphalography (MEG)
Time frame: Baseline measurement and up to 6 month follow-up measurements
Plan to share: No — Individual participant data is not planned to be available to other researchers. However findings from this study is planned to be published in peer-reviewed journal regardless of positive/negative findings
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Aalborg University Hospital