An observational study in Lung Contusion, sponsored by Peking University People's Hospital. Not yet recruiting. Open to participants aged 18 Years to 80 Years. Per ClinicalTrials.gov, last updated 2024-04-26.
Sponsored by Peking University People's Hospital · Observational
The goal of this observational study is to learn about EIT in observing the application of lung protective ventilation strategies in patients with pulmonary contusion, particularly the impact on pulmonary ventilation blood flow ratio, oxygen, and condition. The main question it aims to answer is:
Can lung protective ventilation strategies improve respiratory function in patients with severe chest contusion? We will collect clinical data of participants who already taking lung protective ventilation strategies as part of their regular medical care.
Trauma is the leading cause of death among middle-aged and young people in China, with over 25% of patients dying from chest trauma. The incidence of pulmonary contusion in severe chest trauma is over 70%, and it is an important cause of respiratory failure and even death in patients. The occurrence of pulmonary contusion and respiratory failure in patients with chest contusion is a dynamic process, and Regional inhomogeneities of the damaged lung should be taken into consideration to develop improved ventilation strategies. Currently, there is no ideal monitoring method to evaluate the severity of injury, and guide the ventilation strategies. Electrical impedance tomography (EIT) is a non-invasive, radiation-free imaging technique. It measures regional lung ventilation and aeration distribution by means of changes in electrical potentials at the skin surface of the chest wall during breathing cycles, which has been proven to have good practicality in patients with non-invasive ARDS and pulmonary embolism. In this study, we aim to characterize the physiologic effects of positive end expiratory pressure (PEEP) on key mechanisms of regional lung protection, namely: recruitment, reduced atelectrauma, and improved ventilation-perfusion matching, by CT scan and EIT
43 studies on the registry are indexed under Contusions; 8 are open to participants now.
This study's planned enrollment of 80 is close to the median of 75 across 10 observational studies indexed under Contusions.
Browse Contusions studies →Peking University People's Hospital is the lead sponsor of 609 studies on the registry; 247 are open to participants now.
Counted across the registry records on this site, refreshed daily.
The cohort will be selected from a tertiary hospital
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.
Contraindication
A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
The PEEP titration guided by EIT, decided by the responsible attending physician
Other: PEEP setting strategy
The PEEP setting with low FiO2-PEEP table, decided by the responsible attending physician
Other: PEEP setting strategy
The attending physician selects different PEEP setting strategies
ventilation blood flow ratio
ventilation blood flow ratio of lung
Time frame: through study completion, an average of 1 year
oxygenation index
oxygenation index of participant
Time frame: through study completion, an average of 1 year
28-day mortality
28-day mortality
Time frame: through study completion, an average of 1 year
Mechanical ventilation-free from day 1 to 28
Mechanical ventilation-free from day 1 to 28
Time frame: through study completion, an average of 1 year
Length of ICU stay
Length of ICU stay
Time frame: through study completion, an average of 1 year
Length of hospital stay
Length of hospital stay
Time frame: through study completion, an average of 1 year
The rate of successful weaning
the absence of the requirement for ventilatory support, without reintubation, a cardiac arrest event, or mortality within 48h after extubating or withdrawal
Time frame: through study completion, an average of 1 year
No study locations are listed for this record.
Plan to share: Yes — all collected IPD, all IPD that underlie results in a publication
Supporting information: Study protocol, Statistical analysis plan, Informed consent form
Time frame: starting 1 year after publication
Access criteria: The data used and/or analyzed during the current study are available from the Investigator on reasonable request.
No publications or documents are linked to this record.
Start is estimated for May 2024; primary completion for May 2026, 24 months later.
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This study is not yet recruiting, as verified in Apr 2024. You cannot join it, but the record below documents what was studied.
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