An interventional study of cardiac imaging to assess left ventricular volumes and function in Myocardial Infarction and Ventricular Remodeling, sponsored by University Hospital, Angers. Recruiting at 1 site in France. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-02-09.
Sponsored by University Hospital, Angers · Not applicable, Interventional, and Diagnostic
Following myocardial infarction, female individuals demonstrate a poorer prognosis, characterized by elevated rates of mortality and heart failure. A primary hypothesis suggests unfavorable cardiac remodeling in women. This remodeling, defined as alterations in cardiac size and shape post-infarction, necessitates repeated non-invasive imaging for study.
2,270 studies on the registry are indexed under Myocardial Infarction; 371 are open to participants now.
This study's planned enrollment of 1,650 is above the median of 150 across 1,314 interventional studies indexed under Myocardial Infarction.
Browse Myocardial Infarction studies →University Hospital, Angers is the lead sponsor of 478 studies on the registry; 120 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Inclusion Criteria:
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
left ventricular remodeling measurement with cardiac echography
Diagnostic Test: cardiac imaging to assess left ventricular volumes and function
non-invasive cardiac imaging (echocardiography and MRI)
Asses left ventricular remodeling disparities between genders
The primary outcome measure will be the occurrence of left ventricular remodeling (defined as a change in ventricular volume of more than 10% during follow-up) measured with cardiac imaging (echocardiography and MRI)
Time frame: baseline; 3 months and 1 year after myocardial infarction onset
Evaluate the evolution of remodeling at Month 3
Changes in ventricular volumes between acute phase and 3 months measured with cardiac imaging (echocardiography and MRI)
Time frame: 3 months
Assess remodeling changes between inclusion and Month 12
Changes in ventricular volumes between acute phase and 1 year measured with cardiac imaging (echocardiography and MRI)
Time frame: 1 year
Assess the prevalence of comorbidities and their impact on the effect on the outcome: post-infarction cardiac remodeling with gender (cardiovascular risk factors, renal function, hepatic functionperipheral artery disease, way of life)
renal function: uremia and creatinine levels, combined with an assessment of the protein-to-creatinine ratio in urine samples, and a cyto-bacteriological examination of urine to detect hematuria; hepatic function: The Fibroscan® is a device that enables a non-invasive and efficient assessment of liver fibrosis and steatosis within minutes at the patient's bedside, providing an immediate result displayed on the device screen; peripheral artery disease: Doppler echocardiography of the supra-aortic trunks; way of life : dietetary, stress and physical activity scores common CV risk factors: prior history of hypertension, hypercholesterolaemia, tobacco use, diabetes
Time frame: 3 months and 1 year
Explore prognostic disparities between men and women.
Occurrence of complications and cardiovascular events (cardiovascular death, heart failure, stroke, or reinfarction)
Time frame: yearly, up to 10 years
Evaluate lifestyle habits up to 10 years: outcome anxiety/depression
Anxiety/Depression (A.D) score: 2 scales from 0 to 21, the greatest the more prone to either anxiety or depression
Time frame: yearly, up to 10 years
Evaluate lifestyle habits up to 10 years: outcome diet score
Mediteranean diet score (MED): from 0 to 14, the greatest the more relevant for mediteranean diet
Time frame: yearly, up to 10 years
Evaluate lifestyle habits up to 10 years: outcome physical activity
physical activity: lipid research clinics (LRC); 2 scales from 1 to 5, the greatest the less active
Time frame: yearly, up to 10 years
Assess the risk of remodeling based on specific parameters in female subjects: presence of endometriosis
presence or absence of endometriosis
Time frame: baseline
Assess the risk of remodeling based on specific parameters in female subjects: presence of polycystic ovary
presence or absence of polycystic ovary
Time frame: baseline
Assess the risk of remodeling based on specific parameters in female subjects: presence of uterine fibroma
presence or absence of uterine fibroma
Time frame: baseline
Assess the risk of remodeling based on specific parameters in female subjects: presence of hormonal therapy
presence or absence of hormonal therapy
Time frame: baseline
Assess the risk of remodeling based on specific parameters in female subjects: date of first period
date of first period
Time frame: baseline
Assess the risk of remodeling based on specific parameters in female subjects: pregnancy
number of pregnancy
Time frame: baseline
Assess the risk of remodeling based on specific parameters in female subjects: children
number of children
Time frame: baseline
Assess the risk of remodeling based on specific parameters in female subjects: obstetrical event
absence or presence of obstetrical events (hypertension, diabete, microsomia and macrosomia)
Time frame: baseline
Assess the risk of remodeling based on specific parameters in female subjects: menopause
absence or presence of menopause
Time frame: baseline
Started Jul 2024 (actual). Primary completion is estimated for Nov 2039, 183 months after the start.
Of 321 non-industry interventional studies with no phase under Myocardial Infarction, half reached primary completion within 35 months of starting (the median), counting those still running; a quarter within 14 and three quarters within 58. This study's planned 183 months is above that.
Counting every sponsor, half of 354 studies reached it within 34 months; a quarter within 15 and three quarters within 57.
How these figures are worked out, and which studies are left out of them.
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