CClinicalTrials.gg
Sign In
RecruitingNCT06320665Updated Mar 28, 2025

Assessment of Vertical Pattern in Correlation With Third Molar Inclusion : A 3D CBCT Analysis

An observational study in Impacted Third Molar Tooth, sponsored by Central Hospital, Nancy, France. Recruiting at 1 site in France. Open to participants aged 15 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2025-03-28.

Sponsored by Central Hospital, Nancy, France · Observational

Study type
Observational
Model
Other
Time perspective
Retrospective
Enrollment
80
Ages
15 Years and older
Sex
All
01

Study summary

The objective is to compare the sagittal and vertical skeletal parameters of patients with an impacted third molar.

Patients will be analyzed according to their skeletal characteristics: skeletal class (sagittal direction) and facial skeletal typology (vertical direction).

The inclusion characteristics of third molars will also be analyzed, to see the links between typology and inclusion. The principal hypothesis is no significant difference in third molar inclusion patterns in relation to skeletal divergence.

Read the detailed description

The study is a non-interventional (observational) research involving the human person, research on existing data (retrospective study) and samples dealing with dentofacial orthopedics.

This study analyzes third molar inclusion patterns in relation with the skeletal characteristics, sagittal and vertical typology.

This is a comparative retrospective study of radiographs in three dimensions before any orthodontic treatment. The patients studied are at Bacchetti CS stage 5 (adults), and the third molar must be at least at Nolla stage 6 of formation.

There is no control group but there are subgroups depending of the skeletal characterics.

02

Conditions studied

  • Impacted Third Molar Tooth

Browse trials for

Keywords

  • Cone beam ct
  • third molar
  • Vertical dimension
  • Impacted teeth
  • Orthodontic
  • Adult
  • Skeletal pattern
03

Who can participate

Ages eligible
15 Years and older
Sexes eligible
All
Accepts healthy volunteers
Yes
Sampling method
Probability sample

Study population

French adults with at least one impacted third molar

Inclusion criteria

  • CMV stage 5 on lateral radiography (end of growth)
  • at least one impacted third molar at minimum Nolla stage 6 development

Exclusion criteria

Exclusion Criteria:

  • Previous maxillofacial trauma
  • Growing patients
  • Missing permanent tooth or early avulsion
  • Dysplasia
  • Dentofacial deformities
  • Endocrinological pathologies with implications for maxillofacial growth
  • Syndromes
  • History of maxillofacial or orthognathic surgery
  • History of orthodontic treatment
  • Incomplete data
04

Study design

Observational model
Other
Time perspective
Retrospective
Enrollment
80 participants (estimated)
Patient registry
No

Groups and cohorts

  • Class I

    Patient with class I occlusion, with at least one impacted third molar

    Other: Radiographic measurement

  • Class II

    Patients with class II malocclusion, with at least one impacted third molar

    Other: Radiographic measurement

  • Class III

    Patients with class III malocclusion, with at least one impacted third molar

    Other: Radiographic measurement

Interventions

  • OtherRadiographic measurement

    Measurements taken on 3D radiographs, to assess third molar inclusion and skeletal typology (vertical and sagittal)

05

What researchers measure

Primary outcomes

  1. Distance between the occlusal plane and the second molar

    Depth of the third molar in mm

    Time frame: One day

  2. Angle of the third molar

    The coronal-radicular axis of the mandibular third molar, and the occlusal plane of the mandibular 1st and 2nd molars, when these are in a normal, functional position on the arch (in degrees)

    Time frame: One day

06

Study locations

1 of 1 sites recruiting
  • Département d'Orthopédie dento-faciale
    Nancy, 54000, France
    • Mathilde Laé, intern · Contact · mathildelae@hotmail.fr · + 33 7 81 8938 50
    • Bart Vande Vannet, professor · Contact
    • Mathilde Laé, intern · Principal investigator
    Recruiting
07

References and documents

Publications

  • Idris AM, Al-Mashraqi AA, Abidi NH, Vani NV, Elamin EI, Khubrani YH, Sh Alhazmi A, Alamir AH, Fageeh HN, Meshni AA, Mashyakhy MH, Makrami AM, Gareeb Alla Abdalla A, Jafer M. Third molar impaction in the Jazan Region: Evaluation of the prevalence and clinical presentation. Saudi Dent J. 2021 May;33(4):194-200. doi: 10.1016/j.sdentj.2020.02.004. Epub 2020 Mar 4. PubMed 34025081 ↗
  • Costa MG, Pazzini CA, Pantuzo MC, Jorge ML, Marques LS. Is there justification for prophylactic extraction of third molars? A systematic review. Braz Oral Res. 2013 Mar-Apr;27(2):183-8. PubMed 23538430 ↗
  • Hounsome J, Pilkington G, Mahon J, Boland A, Beale S, Kotas E, Renton T, Dickson R. Prophylactic removal of impacted mandibular third molars: a systematic review and economic evaluation. Health Technol Assess. 2020 Jun;24(30):1-116. doi: 10.3310/hta24300. PubMed 32589125 ↗
  • Tassoker M, Kok H, Sener S. Is There a Possible Association between Skeletal Face Types and Third Molar Impaction? A Retrospective Radiographic Study. Med Princ Pract. 2019;28(1):70-74. doi: 10.1159/000495005. Epub 2018 Oct 31. PubMed 30380552 ↗
  • Legovic M, Legovic I, Brumini G, Vandura I, Cabov T, Ovesnik M, Mestrovic S, Slaj M, Skrinjaric A. Correlation between the pattern of facial growth and the position of the mandibular third molar. J Oral Maxillofac Surg. 2008 Jun;66(6):1218-24. doi: 10.1016/j.joms.2007.12.013. PubMed 18486787 ↗
  • Aoun Y, Husseini B, Younes R, Ghosn N, Bouserhal J. Assessment of lower third molar space: A comparative radiographic study. Dentomaxillofac Radiol. 2022 Jul 1;51(5):20220049. doi: 10.1259/dmfr.20220049. Epub 2022 May 4. PubMed 35466682 ↗
  • Zamora N, Llamas JM, Cibrian R, Gandia JL, Paredes V. A study on the reproducibility of cephalometric landmarks when undertaking a three-dimensional (3D) cephalometric analysis. Med Oral Patol Oral Cir Bucal. 2012 Jul 1;17(4):e678-88. doi: 10.4317/medoral.17721. PubMed 22322503 ↗
  • Li C, Teixeira H, Tanna N, Zheng Z, Chen SHY, Zou M, Chung CH. The Reliability of Two- and Three-Dimensional Cephalometric Measurements: A CBCT Study. Diagnostics (Basel). 2021 Dec 7;11(12):2292. doi: 10.3390/diagnostics11122292. PubMed 34943528 ↗
  • Carter K, Worthington S. Predictors of Third Molar Impaction: A Systematic Review and Meta-analysis. J Dent Res. 2016 Mar;95(3):267-76. doi: 10.1177/0022034515615857. Epub 2015 Nov 11. PubMed 26561441 ↗
  • Bin Rubaia'an MA, Neyaz A, Talic F, Alkhamis A, Alghabban A, Assari A. The Association Between Skeletal Facial Types and Third Molars Impaction in a Saudi Arabian Subpopulation: A CBCT Study. Clin Cosmet Investig Dent. 2023 Aug 15;15:143-156. doi: 10.2147/CCIDE.S419325. eCollection 2023. PubMed 37601239 ↗
  • Baccetti T, Franchi L, McNamara JA Jr. An improved version of the cervical vertebral maturation (CVM) method for the assessment of mandibular growth. Angle Orthod. 2002 Aug;72(4):316-23. doi: 10.1043/0003-3219(2002)0722.0.CO;2. PubMed 12169031 ↗
  • Hagg U, Taranger J. Dental emergence stages and the pubertal growth spurt. Acta Odontol Scand. 1981;39(5):295-306. doi: 10.3109/00016358109162293. PubMed 6950638 ↗
  • Hasan KM, Sobhana CR, Rawat SK, Singh D, Mongia P, Fakhruddin A. Third molar impaction in different facial types and mandibular length: A cross-sectional study. Natl J Maxillofac Surg. 2021 Jan-Apr;12(1):83-87. doi: 10.4103/njms.NJMS_111_20. Epub 2021 Mar 16. PubMed 34188406 ↗
  • Mollaoglu N, Cetiner S, Gungor K. Patterns of third molar impaction in a group of volunteers in Turkey. Clin Oral Investig. 2002 Jun;6(2):109-13. doi: 10.1007/s00784-001-0144-1. PubMed 12166710 ↗
  • Jaron A, Trybek G. The Pattern of Mandibular Third Molar Impaction and Assessment of Surgery Difficulty: A Retrospective Study of Radiographs in East Baltic Population. Int J Environ Res Public Health. 2021 Jun 3;18(11):6016. doi: 10.3390/ijerph18116016. PubMed 34205078 ↗
  • Hashemipour MA, Tahmasbi-Arashlow M, Fahimi-Hanzaei F. Incidence of impacted mandibular and maxillary third molars: a radiographic study in a Southeast Iran population. Med Oral Patol Oral Cir Bucal. 2013 Jan 1;18(1):e140-5. doi: 10.4317/medoral.18028. PubMed 23229243 ↗
  • Ahmed M, Shaikh A, Fida M. Diagnostic validity of different cephalometric analyses for assessment of the sagittal skeletal pattern. Dental Press J Orthod. 2018 Sep-Oct;23(5):75-81. doi: 10.1590/2177-6709.23.5.075-081.oar. PubMed 30427496 ↗

Individual participant data

Plan to share: Undecided

08

Registry details

Key details

Study ID
NCT06320665
Lead sponsor
Central Hospital, Nancy, France
Responsible party
VANDE VANNET Bart (Professor, Central Hospital, Nancy, France) — Principal investigator
First posted
Mar 20, 2024
Start date
Dec 1, 2024
Primary completion
Jul 30, 2025 (estimated)
Completion
Sep 30, 2025 (estimated)
Last update
Mar 28, 2025

Study contacts

Bart VANDE VANNET, PhD
Contact
bart.vande-vannet@univ-lorraine.fr
+32496284339
Mathilde LAE
Contact
mathildelae@hotmail.fr
+33781893850
Bart VANDE VANNET, PhD
study director · Central Hospital, Nancy, France

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Interested in this study?

Eligibility is decided by the study team. Share this record with your doctor or contact the team directly.

Contact study team

Follow this study

Get an email when the registry record changes — status, dates, results — or when someone posts here.

Sign in to follow

Discussion

Questions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.

Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.

Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.

Other studies in this condition

Tooth, Impacted→

Other studies from this sponsor

Central Hospital, Nancy, France

Start the discussion