An interventional study of Retrograde Intraarticular Injection via Drain Tube and Topical Soaking of Tranexamic Acid in Femoral Neck Fracture, sponsored by King Chulalongkorn Memorial Hospital. Recruiting at 2 sites in Thailand. Open to participants aged 60 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-08-05.
Sponsored by King Chulalongkorn Memorial Hospital · Not applicable, Interventional, and Treatment
The goal of this Randomized controlled trial is to evaluate in household ambulatory, elderly patients sustaining femoral neck fracture who are subjected to be treat with cementless bipolar hemiarthroplasty. The main questions it aims to answer are:
As having undergone bipolar hemiarthroplasty surgery, participants will either receive retrograde intraarticular tranexamic acid injection via drain tube, or topical soaking administration.
Researchers will compare, with standard procedure (procedure), whether topically administered tranexamic acid would reduce rate of blood transfusion.
Perioperative blood loss and transfusion are common in elderly patients undergoing bipolar hemiarthroplasty for femoral neck fractures, and are associated with anemia-related morbidity and transfusion-related risk. Although tranexamic acid (TXA) reduces blood loss and transfusion in elective arthroplasty, topical administration has been proposed to preserve local hemostatic efficacy while limiting systemic exposure in this comorbid population, but the optimal topical route in hip fracture surgery remains uncertain.
This study compared the efficacy and safety of topical soaking (TS) and intra-articular (IA) TXA with placebo in patients undergoing bipolar hemiarthroplasty.
Exclusion Criteria:
Tranexamic acid will be injected retrograde to the joint via drain tube after surgical wound closure
Drug: Retrograde Intraarticular Injection via Drain Tube
Tranexamic acid will be placed to soak the intramedullary canal of the femur and surgical area after sheath closure for 5 minutes and completely remove by sunction
Drug: Topical Soaking of Tranexamic Acid
Standard wound irrigation
Drug: Placebo Comparator: Standard procedure (placebo)
Tranexamic acid will be injected via drain tube after wound closure
Tranexamic acid will be topically administered by soaking method
Standard wound management
Rate of blood transfusion
Proportion of patients received blood transfusion divided by total number of patient in a group
Time frame: 2 years, or until complete enrollment
Volume of blood transfusion
total volume of blood transfusion per each patient
Time frame: 2 years, or until complete enrollment
Calculated blood loss
Calculating using Nadler and Goss formula
Time frame: 2 years, or until complete enrollment
Any adverse events
Adverse events include wound complication, deep vein thrombosis, pulmonary embolism, and other complication
Time frame: 2 years, or until complete enrollment
In-hospital mortality
In-hospital mortality
Time frame: During admission period
Plan to share: No
No publications or documents are linked to this record.
Eligibility is decided by the study team. Share this record with your doctor or contact the team directly.
Contact study teamGet an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
King Chulalongkorn Memorial Hospital