An observational study in Hypercholesterolemia, sponsored by Federico II University. Recruiting at 1 site in Italy. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-01-22.
Sponsored by Federico II University · Observational
Evaluation of adherence, persistence and efficacy of treatment with Inclisiran in a real-life Italian population
1,238 studies on the registry are indexed under Hypercholesterolemia; 110 are open to participants now.
This study's planned enrollment of 3,000 is above the median of 800 across 185 observational studies indexed under Hypercholesterolemia.
Browse Hypercholesterolemia studies →Federico II University is the lead sponsor of 356 studies on the registry; 60 are open to participants now.
Counted across the registry records on this site, refreshed daily.
The study population includes patients from Italy, who have received Inclisiran as part of routine clinical management of their hyperlipidaemia, based on national reimbursement criteria, at time of enrollment
Exclusion Criteria:
Drug: Inclisiran
Injection
Description of adherence to treatment with Inclisiran in a real-life Italian population
Adherence will be assessed in terms of Medical Possession Ratio (MPR) which is defined as the ratio between the treatment units dispensed during the treatment period and the duration of the treatment period itself.
Time frame: at 3 months and every 6 months thereafter
Description of persistence to treatment with Inclisiran in a real-life Italian population
Persistence will be assessed in terms of therapeutic continuity from the start of treatment to enrollment.
Time frame: at 3 months and every 6 months thereafter
Description of efficacy of treatment with Inclisiran in a real-life Italian population
Efficacy of treatment will be evaluated as a change in the LDL (deltaLDL) value from the start of treatment (percentage and absolute value). The deltaLDL will be calculated as an overall (mean and median value), by type of prevention (primary and secondary), by type of basic therapy, by demographic variables (age, sex, geographic origin, basal LDL levels) and by type of prescriber (hospital or territorial).
Time frame: at 3 months and every 6 months thereafter
Plan to share: No
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Federico II University