An observational study in Auditory Perception, sponsored by Institut Pasteur. Recruiting at 2 sites in 2 countries. Open to participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2025-03-03.
Sponsored by Institut Pasteur · Observational
The COMPRESSED project is a descriptive, bi-centric and non-invasive study carried out by the CERIAH - IDA - Institut Pasteur and the Haute École Léonard de Vinci in Brussels on volunteer participants identified in two groups :
The main objective of the COMPRESSED study is to evaluate the auditory effects of exposure to manipulated sounds (compression, filtering, equalisation, accentuation, etc.) from sound distribution platforms on the auditory system of participants who are regularly exposed to these sounds as a result of their professional activity.
Institut Pasteur is the lead sponsor of 96 studies on the registry; 40 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Subjects with sustained exposure to compressed sounds, as defined by professional participation in broadcast platform events using sound signal processing systems, over the last 3 years, Or Subjects with moderate or limited exposure to compressed and manipulated sound, equivalent to that of a student taking distance-learning courses on a videoconferencing platform, alternating with other face-to-face courses, with the possibility of pauses in listening, exposed for a maximum of 2 years.
For all participants:
For participants in the high exposure group:
For participants in the moderate or limited exposure group:
Exclusion Criteria:
Other: Audiological profile · Other: Hearing self-assessments · Other: Objective and subjective audiological tests · Other: Self-assessment of exposure sound quality
Other: Audiological profile · Other: Hearing self-assessments · Other: Objective and subjective audiological tests · Other: Self-assessment of exposure sound quality
Video otoscopy Tympanometry High-frequency tonal audiometry
Hearing skills questionnaire Subjective assessment of tinnitus using a visual analogue scale Self-questionnaire on the impact of tinnitus Hyperacusis self-questionnaire
Acoustic Omission Measurement of the stapedial reflex by tympanometry High-frequency tonal audiometry - exposed ear only Speech audiometry in noise Tinnitus and subjective discomfort thresholds Psychoacoustic intensity perception test
A self-assessment of the sound quality of the manipulated sounds heard during the exhibition will be carried out during the second follow-up visit. The elements on which the participant will be asked to make a qualitative judgement will relate to intelligibility difficulties or not; background noise (these two items in the form of a mark between 0 and 10); the clear, muffled or shrill nature of the sounds, their resonant or saturated side.
Hearing assessments of participants exposed to manipulated sounds after and before exposure
Measurement of the difference between the hearing assessments of participants exposed to manipulated sounds after and before exposure
Time frame: 2 weeks
Audiometric thresholds in pure tone from 125 to 8000 Hz in the subject's exposed ear before and approximately one hour after exposure,
Measurement of the difference between audiometric thresholds in pure tone from 125 to 8000 Hz in the subject's exposed ear before and approximately one hour after exposure,
Time frame: 2 weeks
Difference between the threshold of the protective reflex of the auditory pathways (middle ear muscles) measured by impedancemetry in the exposed ear when a contralateral noise is presented for a few seconds.
A contralateral noise is a low-pass filtered white noise with a cut-off at 3 kHz.
Time frame: 2 weeks
Levels of otoemissions in acoustic distortion products in the exposed ear in response to pure tone sound stimuli
Comparison of the levels of otoemissions in acoustic distortion products in the exposed ear in response to pure tone sound stimuli at 65 dB SPL around 1, 2, 3 and 4 kHz, before and approximately one hour after exposure.
Time frame: 2 weeks
Tinnitus or auditory distortion (hyperacusis) reported by participants before and after exposure.
Measurement of the difference in the perception of tinnitus or auditory distortion (hyperacusis) reported by participants before and after exposure.
Time frame: 2 weeks
Effectiveness of the protective auditory reflexes (or acoustic reflexes), obtained by impedancemetry and derived from the reading of the otoemissions for each participant.
Measurement of the difference of the effectiveness of the protective auditory reflexes (or acoustic reflexes), obtained by impedancemetry and derived from the reading of the otoemissions for each participant.
Time frame: 2 weeks
Plan to share: No
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