An observational study in Sepsis, sponsored by University Clinical Centre of Republic of Srpska. Recruiting at 1 site in Bosnia and Herzegovina. Per ClinicalTrials.gov, last updated 2024-02-15.
Sponsored by University Clinical Centre of Republic of Srpska · Observational
The object of the scientific research is the characterization of the pharmacokinetic profile and the investigation of factors of pharmacokinetic variability of amikacin and vacnomycin in critically ill patients with a diagnosis of sepsis-like condition (SIRS), hospital-acquired sepsis and/or septic shock and who are on extracorporeal therapy with Cytosorb® and Oxiris® adsorbents.
1,881 studies on the registry are indexed under Critical Illness; 462 are open to participants now.
This study's planned enrollment of 20 is below the median of 130 across 867 observational studies indexed under Critical Illness.
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Adult critically ill patients with a diagnosis of SIRS, sepsis and/or septic shock who are hospitalized in the Department of Medical Intensive Care Medicine
Exclusion Criteria:
Device: Cytosorb® and Oxiris® adsorbents
Device: Cytosorb® and Oxiris® adsorbents
The pharmacokinetic profile and the investigation of factors of pharmacokinetic variability of amikacin and vacnomycin in critically ill patients with a diagnosis of sepsis-like condition (SIRS), hospital-acquired sepsis and/or septic shock and who are on extracorporeal therapy with Cytosorb® and Oxiris® adsorbents.
Also known as: Drugs' concentrations measurements
Development of population pharmacokinetic model
Measurement of amikacin and vancomycine serum concentrations in several time points in order to gain pharmacokinetic profiles of previously mentioned drugs and to develop population pharmacokinetic model of amikacin and vancomycin by nonlinear modeling of combined effects in critically ill patients on veno-venous hemodiafiltration with two types of adsorbents.
Time frame: One year
Plan to share: No
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University Clinical Centre of Republic of Srpska