An interventional study of NanoChitosan impregnated Calcium Hydroxide in Intervention, sponsored by Cairo University. Not yet recruiting. Open to participants aged 25 Years to 45 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2024-02-12.
Sponsored by Cairo University · Not applicable, Interventional, and Treatment
This research will study the effect of NanoChitosan impregnated Calcium Hydroxide versus Calcium Hydroxide as an intracanal medication on postoperative pain intensity measured using numerical rating scale (NRS) and bacterial load reduction determined by bacterial counting using agar culture technique after root canal preparation (CFU/ml) in necrotic teeth.
Primary outcome: Postoperative pain measured using numerical rating scale (NRS)
Secondary outcome: Bacterial load reduction determined by bacterial counting using agar culture technique after root canal preparation (CFU/ml)
5,089 studies on the registry are indexed under Pain, Postoperative; 1,137 are open to participants now.
This study's planned enrollment of 45 is below the median of 75 across 4,341 interventional studies indexed under Pain, Postoperative.
Browse Pain, Postoperative studies →Cairo University is the lead sponsor of 4,780 studies on the registry; 1,427 are open to participants now.
Of its 36 completed or terminated interventional studies of FDA-regulated products, 5 (14%) have results posted.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Teeth that require further procedural steps or multidisciplinary approach.
25-45 years old patients with necrotic single rooted mandibular premolars with single canal will be treated with NanoChitosan impregnated Calcium Hydroxide as an intracanal medicament for 7 days
Combination Product: NanoChitosan impregnated Calcium Hydroxide
25-45 years old patients with necrotic single rooted mandibular premolars with single canal will be treated with calcium hydroxide as an intracanal medicament for 7 days
Combination Product: NanoChitosan impregnated Calcium Hydroxide
NanoChitosan impregnated Calcium Hydroxide used as an intracanal medication fro 7 days
Postoperative pain measured using numerical rating scale
postoperative pain will be recorded after placement of intracanal medicament and after root canal obturation using numerical rating scale ,An 11-point scale from 0-10 representing pain intensity ,"10" being the most intense pain conceivable.
Time frame: 48 hours
Bacterial load reduction
Bacterial load reduction determined by bacterial counting using agar culture technique after root canal preparation (Number of colony forming unit per millilitre)
Time frame: T0=Baseline immediate after access preparation . T1=Post-instrumentation. T2=post-intracanal medicament removal at 7 days.
Incidence of inter- appointment flare up
recording the incidence of inter-appointment flare up with a binary scale
Time frame: Up to 48 hours post- operatively
Number of analgesic tablets taken by the patient after endodontic treatment
Number of analgesic tablets intake after root canal treatment, using numerical counting.
Time frame: Up to 48 hours post- operatively
No study locations are listed for this record.
Plan to share: Yes
No publications or documents are linked to this record.
This study is not yet recruiting, as verified in Feb 2024. You cannot join it, but the record below documents what was studied.
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Cairo University