An observational study in Acute Pancreatitis, sponsored by The First Affiliated Hospital of Nanchang University. Not yet recruiting at 1 site in China. Open to participants aged 18 Years to 75 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2024-01-30.
Sponsored by The First Affiliated Hospital of Nanchang University · Observational
The goal of this observational study is to learn about the biomarkers and mechanisms of severe acute pancreatitis in 30 healthy controls, 30 patients of mild acute pancreatitis, 30 patients of moderately severe acute pancreatitis, and 86 patients of severe acute pancreatitis. The main question it aims to answer are: • The relationship between changes in gut microbiota and clinical prognosis (plasma inflammatory cytokines, incidence and duration of infection in various parts, mortality rate), and the screening and validation of biomarkers that can be used for early prediction of disease severity. • Analyze the relationship between changes in blood composition and clinical prognosis (plasma inflammatory cytokines, incidence and duration of infection in various parts, mortality rate), screen and verify biomarkers that can be used for early prediction of disease severity. Blood and fecal samples from the healthy control group and diagnosed patients will be collected.
752 studies on the registry are indexed under Pancreatitis; 181 are open to participants now.
This study's planned enrollment of 176 is close to the median of 180 across 277 observational studies indexed under Pancreatitis.
Browse Pancreatitis studies →The First Affiliated Hospital of Nanchang University is the lead sponsor of 26 studies on the registry; 14 are open to participants now.
Counted across the registry records on this site, refreshed daily.
30 healthy controls, 30 patients of mild acute pancreatitis, 30 patients of moderately severe acute pancreatitis and 86 patients of severe acute pancreatitis, a total of 176 cases were included.
Patients group:
① Age between 18 and 75 years old;
② Within 72 hours of AP onset;
③ AP patients who meet the 2012 Atlanta AP Classification and Diagnostic Criteria.
Healthy control group:
Exclusion Criteria:
Used antibiotics, probiotics, and acid suppressants 4 weeks before enrollment;
Pregnant and lactating women;
Hypothyroidism, nephrotic syndrome, Cushing's syndrome, AIDS;
Composition of gut microbiota
The gut microbiota plays an important role in protecting the intestinal barrier, regulating metabolism, and participating in immune responses in the human body, and is an important component of the gut ecosystem.
Time frame: through study completion, an average of 1 year
Composition of gut metabolites
Metabolites can reveal the intrinsic correlation between metabolic products and physiological and pathological changes in the body, thereby achieving recognition of the overall state of the body.
Time frame: through study completion, an average of 1 year
Composition of metabolites in plasma
Metabolites can reveal the intrinsic correlation between metabolic products and physiological and pathological changes in the body, thereby achieving recognition of the overall state of the body.
Time frame: through study completion, an average of 1 year
composition of proteins in plasma
Proteins are an important material foundation for life activities and the main executors of life processes such as cell proliferation, differentiation, aging, and death.
Time frame: through study completion, an average of 1 year
Plan to share: Undecided
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This study is not yet recruiting, as verified in Jan 2024. You cannot join it, but the record below documents what was studied.
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The First Affiliated Hospital of Nanchang University