An interventional study of salt in High Blood Pressure, sponsored by Mulungushi University. Recruiting at 2 sites in Zambia. Open to participants aged 18 Years to 50 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2024-01-26.
Sponsored by Mulungushi University · Not applicable, Interventional, and Diagnostic
The goal of this study is to establish a diagnostic accuracy of an immediate pressor response to oral salt (IPROS) to identify salt sensitivity of blood pressure (SSBP)
Participants are given dietary salt and their BP is measured every 10 minutes for 2 hours. IPROS is diagnosed with significant mean arterial pressure increase
For SSBP, participants are put on high salt diet for a week and monitored and low salt week. The Mean arterial pressure difference between high salt and low salt is used to diagnose SSBP
6,114 studies on the registry are indexed under Hypertension; 912 are open to participants now.
This study's planned enrollment of 300 is above the median of 100 across 4,575 interventional studies indexed under Hypertension.
Browse Hypertension studies →Mulungushi University is the lead sponsor of 3 studies on the registry; 1 is open to participants now.
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Exclusion Criteria:
intervention given
Other: salt
After ≥8 hr overnight fasting, participants will be required to ingest 780 mg of sodium (2 g salt) and BP measured every 10 minutes for 2 hours to determine IPROS. For SSBP, Participants are put on low salt (50 mmol Na/day) followed by seven days of high salt diet (250 mmol Na/day). Participants' mean arterial pressure (MAP) difference between low- and high-salt diet will be used to define salt sensitivity (MAP≥8 mmHg) and salt resistance (MAP≤5 mmHg).
SSBP
Salt sensitivity status
Time frame: 2 weeks
IPROS
Immediate pressor response
Time frame: 2 hours
Plan to share: Yes — Data set and manuscripts published
Supporting information: Clinical study report
Time frame: 2025
Access criteria: email
No publications or documents are linked to this record.
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Mulungushi University