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Not yet recruitingNCT06220240Updated Jan 23, 2024

Energy Deficiency and Athletic Performance

An interventional study of Modified Training Programme and Routine Training Programme in Female Athlete Triad, sponsored by Istanbul University - Cerrahpasa. Not yet recruiting at 1 site in Turkey. Open to female participants aged 18 Years to 35 Years. Per ClinicalTrials.gov, last updated 2024-01-23.

Sponsored by Istanbul University - Cerrahpasa · Not applicable, Interventional, and Treatment

Phase
Not applicable
Study type
Interventional
Enrollment
78
Allocation
Randomized
Ages
18 Years to 35 Years
Sex
Female
01

Study summary

Energy availability (EA) refers to the balance between daily energy intake and exercise energy expenditure. Athletically inadequate EA is defined as low energy availability (LEA). Energy deficits occur throughout life, from young athletes with a relative lack of energy in sports or the female athlete triad to older adults struggling with weight loss. Acute and/or chronic LEA can cause negative athletic and health outcomes in athletes.

It is known that LEA, as an energy saving mechanism, suppresses the reproductive system and causes disruption of the menstrual cycle, as well as causing many interrelated endocrine-related physiological consequences by changing other hormonal pathways. Menstrual dysfunction due to LEA causes various risks as it can disrupt the EC during training and competition. Therefore, low EA may contribute to poor sports performance due to detrimental endocrine effects.

Various parameters such as body mass and nutritional intake affect the performance of athletes, and LEA is frequently reported among athletes with intense training programs. LEA combined with high training volumes; It can cause negative consequences such as impaired protein synthesis/degradation rate, impaired hormonal and training response, increased risk of fatigue, and these can lead to decreased performance. Resting metabolic rate, which indicates the energy expended for basic body functions, is considered a potential objective indicator of energy availability.

Regulation of dietary energy intake in the management of LEA in athletes covers a wide area in the literature. However, LEA is caused not only by a deficiency in energy intake but also by an excess in energy expenditure. In the light of this information, the aim of the study is to examine the acute period effects of the training program in which exercise energy expenditure is reduced in terms of energy availability and athletic performance.

Read the detailed description

Voluntary participants who have been diagnosed with energy deficiency will be included in the study. Signed voluntary consent will be obtained from participants. Participants will be divided into two groups. Study groups will be as follows: a) Modified Training, b) Routine Training.

02

Conditions studied

  • Female Athlete Triad

Keywords

  • Energy Deficiency
  • Eccentric Exercise
  • Athletic Performans
03

Who can participate

Ages eligible
18 Years to 35 Years
Sexes eligible
Female
Accepts healthy volunteers
No

Inclusion criteria

  • 18- 35 years old female gender
  • Body mass index being less than 18.50-24.99 kg/m2
  • Having a energy deficiency
  • Been interested in basketball professionally for at least one year
  • Must be training with the team at least 3 days a week
  • Performance levels should be 3-4

Exclusion criteria

Exclusion Criteria:

  • Having a history of any fracture in the last year
  • Having had a sports injury in the last 8 months
  • Having had an infectious disease in the last 6 months being a smoker
  • Getting 2 or more points from the SCOFF survey
  • Having been using any medication regularly for the last 6 months
04

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Single (Outcomes assessor)
Enrollment
78 participants (estimated)

Study arms

  • Active comparator
    Modified Training Group

    It is a training program that will be carried out under the supervision of a physiotherapist. There will be 3-minute breaks between sets. A training program will be applied to the athletes based on revising the training program they use in their routine with eccentric contractions.

    Other: Modified Training Programme

  • Active comparator
    Routine Training Group

    The training program that the athlete uses in her normal routine will be implemented under the supervision of a physiotherapist.

    Other: Routine Training Programme

Interventions

  • OtherModified Training Programme

    Eccentric muscle contractions and 3-minute rest breaks will be used.

  • OtherRoutine Training Programme

    A routine training program will be used.

05

What researchers measure

Primary outcomes

  1. Energy Availability

    The underlying etiology of Relative Energy Deficiency in Sports is low energy availability, which occurs when dietary energy intake is inadequate for an athlete's physical activity level. "Energy availability = Energy Intake (kcal) - Exercise Energy Expenditure (kcal/fat - free mass \[fat free mass; kg\])"

    Time frame: change from baseline pain at 2 weeks

  2. Relative Energy Deficiency in Sports Clinical Assessment Tool (RED-S CAT)

    It is a clinical assessment tool used to evaluate athletes or active individuals with suspected low energy availability and serves as a guide for clinicians and coaches in return-to-play decisions.

    Time frame: 3 times for 2 weeks

  3. Running Performance Analysis - Biomechanics

    Performance analysis will be performed on a 10-meter platform with DigitSole in order to evaluate the biomechanics.

    Time frame: 3 times for 2 weeks

  4. Running Performance Analysis - Running Speed

    Performance analysis will be performed on a 10-meter platform with DigitSole in order to evaluate the running speed.

    Time frame: 3 times for 2 weeks

  5. Running Performance Analysis - Economy of the Running

    Performance analysis will be performed on a 10-meter platform with DigitSole in order to evaluate the economy of the athlete's running activity.

    Time frame: 3 times for 2 weeks

Secondary outcomes

  1. Gonadotropin-Releasing Hormone Levels

    Low energy availability is a condition that suppresses and disrupts hormonal function.

    Time frame: 3 times for 2 weeks

  2. Adrenocorticotropic Hormone Levels

    Low energy availability is a condition that suppresses and disrupts hormonal function.

    Time frame: 3 times for 2 weeks

  3. thyroid stimulating Hormone Levels

    Low energy availability is a condition that suppresses and disrupts hormonal function.

    Time frame: 3 times for 2 weeks

  4. Luteinizing Hormone Levels

    Low energy availability is a condition that suppresses and disrupts hormonal function.

    Time frame: 3 times for 2 weeks

  5. Follicle-stimulating Hormone Levels

    Low energy availability is a condition that suppresses and disrupts hormonal function.

    Time frame: 3 times for 2 weeks

  6. Vertical Jump

    The athlete will be positioned in a standing vertical position, with his feet shoulder-width apart. The athlete will reach the highest point he can in the vertec and this point will be considered the zero point. It will be asked to jump 3 times on a force plate to the highest level it can jump and the highest value will be recorded.

    Time frame: 3 times for 2 weeks

06

Study locations

1 site
  • Bezmialem Vakif University
    Istanbul, 34093, Turkey
07

References and documents

Publications

  • Loucks AB, Kiens B, Wright HH. Energy availability in athletes. J Sports Sci. 2011;29 Suppl 1:S7-15. doi: 10.1080/02640414.2011.588958. Epub 2011 Jul 28. PubMed 21793767 ↗
  • Mountjoy M, Sundgot-Borgen JK, Burke LM, Ackerman KE, Blauwet C, Constantini N, Lebrun C, Lundy B, Melin AK, Meyer NL, Sherman RT, Tenforde AS, Klungland Torstveit M, Budgett R. IOC consensus statement on relative energy deficiency in sport (RED-S): 2018 update. Br J Sports Med. 2018 Jun;52(11):687-697. doi: 10.1136/bjsports-2018-099193. No abstract available. PubMed 29773536 ↗
  • De Souza MJ, Nattiv A, Joy E, Misra M, Williams NI, Mallinson RJ, Gibbs JC, Olmsted M, Goolsby M, Matheson G; Female Athlete Triad Coalition; American College of Sports Medicine; American Medical Society for Sports Medicine; American Bone Health Alliance. 2014 Female Athlete Triad Coalition consensus statement on treatment and return to play of the female athlete triad: 1st International Conference held in San Francisco, CA, May 2012, and 2nd International Conference held in Indianapolis, IN, May 2013. Clin J Sport Med. 2014 Mar;24(2):96-119. doi: 10.1097/JSM.0000000000000085. PubMed 24569429 ↗
  • Loucks AB, Stachenfeld NS, DiPietro L. The female athlete triad: do female athletes need to take special care to avoid low energy availability? Med Sci Sports Exerc. 2006 Oct;38(10):1694-700. doi: 10.1249/01.mss.0000239397.01203.83. No abstract available. PubMed 17019289 ↗
  • Heikura IA, Burke LM, Bergland D, Uusitalo ALT, Mero AA, Stellingwerff T. Impact of Energy Availability, Health, and Sex on Hemoglobin-Mass Responses Following Live-High-Train-High Altitude Training in Elite Female and Male Distance Athletes. Int J Sports Physiol Perform. 2018 Sep 1;13(8):1090-1096. doi: 10.1123/ijspp.2017-0547. Epub 2018 Sep 13. PubMed 29431548 ↗
  • Joy E, De Souza MJ, Nattiv A, Misra M, Williams NI, Mallinson RJ, Gibbs JC, Olmsted M, Goolsby M, Matheson G, Barrack M, Burke L, Drinkwater B, Lebrun C, Loucks AB, Mountjoy M, Nichols J, Borgen JS. 2014 female athlete triad coalition consensus statement on treatment and return to play of the female athlete triad. Curr Sports Med Rep. 2014 Jul-Aug;13(4):219-32. doi: 10.1249/JSR.0000000000000077. PubMed 25014387 ↗
  • Joy E, Kussman A, Nattiv A. 2016 update on eating disorders in athletes: A comprehensive narrative review with a focus on clinical assessment and management. Br J Sports Med. 2016 Feb;50(3):154-62. doi: 10.1136/bjsports-2015-095735. PubMed 26782763 ↗
  • Elliott-Sale KJ, Tenforde AS, Parziale AL, Holtzman B, Ackerman KE. Endocrine Effects of Relative Energy Deficiency in Sport. Int J Sport Nutr Exerc Metab. 2018 Jul 1;28(4):335-349. doi: 10.1123/ijsnem.2018-0127. Epub 2018 Jul 14. PubMed 30008240 ↗
  • Logue DM, Madigan SM, Melin A, Delahunt E, Heinen M, Donnell SM, Corish CA. Low Energy Availability in Athletes 2020: An Updated Narrative Review of Prevalence, Risk, Within-Day Energy Balance, Knowledge, and Impact on Sports Performance. Nutrients. 2020 Mar 20;12(3):835. doi: 10.3390/nu12030835. PubMed 32245088 ↗
08

Registry details

Key details

Study ID
NCT06220240
Lead sponsor
Istanbul University - Cerrahpasa
Responsible party
Aysenur Erekdag (Principal Investigator, Istanbul University - Cerrahpasa) — Principal investigator
First posted
Jan 23, 2024
Start date
Jun 2024 (estimated)
Primary completion
Jun 2025 (estimated)
Completion
Dec 2025 (estimated)
Last update
Jan 23, 2024

Study contacts

Ayşenur Erekdağ, MSc
Contact
aysenurerekdag@gmail.com
05548959013

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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