An observational study in Critical Illness and Fluid Overload, sponsored by Mahidol University. Completed at 1 site in Thailand. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2025-05-29.
Sponsored by Mahidol University · Observational
This clinical trial aims to study intrarenal venous flow patterns change, VExUS score change, and LUS score change during fluid removal treatment in critically ill patients
Background: In patients with heart failure, intrarenal venous flow patterns could change depending on the level of congestion and was strongly correlated with death from cardiovascular disease and unplanned hospitalization. However, the findings may differ in patients with sepsis in the intensive care unit. In this case, Intrarenal venous flow patterns were not associated with Central Venous Pressure but were associated with Acute Kidney Injury and death. This suggests that intrarenal venous flow patterns may serve as an indicator of renal congestion and could be a feasible bedside tool to predict various clinical implications. In addition, Point-of-care ultrasound (POCUS) techniques such as Venous Excess Ultrasound (VExUS) and Lung Ultrasound (LUS) provide non-invasive assessments of fluid status and venous congestion. This study evaluates changes in VExUS and LUS scores during fluid removal to predict clinical outcomes in critically ill patients.
Objective: We aimed to study intrarenal venous flow patterns change, VExUS score change, and LUS score change during fluid removal treatment in critically ill patients.
Methods:
Researchers will collect data about
1,881 studies on the registry are indexed under Critical Illness; 462 are open to participants now.
This study's enrollment of 52 is below the median of 130 across 867 observational studies indexed under Critical Illness.
Browse Critical Illness studies →Mahidol University is the lead sponsor of 730 studies on the registry; 118 are open to participants now.
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Adult patients aged 18 years old or older who will be admitted to the medical intensive care unit and require fluid removal therapy
Exclusion Criteria:
intrarenal venous flow patterns change during fluid removal treatment in critically ill patients.
intrarenal venous flow patterns change measured by ultrasonography
Time frame: 72 hours after Fluid removal therapy
VExUS score change following fluid removal treatment in critically ill patients.
VExUS score change measured by ultrasonography
Time frame: 72 hours after Fluid removal therapy
Plan to share: Yes — All Individual participant data that underlie results in a publication of this study (after deidentification)
Supporting information: Study protocol, Sap, Analytic code
This study is completed, as verified in May 2025. You cannot join it, but the record below documents what was studied.
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Mahidol University