An interventional study of therapeutic-educational physiotherapy and pain education program and pain education program in Endometriosis, Chronic Pain and Women's Health, sponsored by University of Valencia. Recruiting at 1 site in Spain. Open to female participants aged 18 Years to 45 Years. Per ClinicalTrials.gov, last updated 2026-05-19.
Sponsored by University of Valencia · Not applicable, Interventional, and Treatment
This is a randomized clinical trial that will be carried out in women with endometriosis divided into two groups: the experimental group (EG) that will receive therapeutic-educational physiotherapy, which will combine therapeutic exercise with a pain education program, and the control group (CG) who will receive the pain education program.
The participants will be evaluated at three moments: before starting the study (T1), after the 8-week treatment program (T2) and after another 8 weeks of follow-up in which they will be encouraged to continue with the treatment (T3). The initial assessment will include a medical and physiotherapy history, and at T1, T2 and T3 the following will be assessed: pain, abdominopelvic mobility, muscle status, functionality, sexual function, quality of life, stress and biomarkers of chronic inflammation.
901 studies on the registry are indexed under Endometriosis; 259 are open to participants now.
This study's planned enrollment of 62 is close to the median of 64 across 525 interventional studies indexed under Endometriosis.
Browse Endometriosis studies →University of Valencia is the lead sponsor of 349 studies on the registry; 73 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
They will receive therapeutic-educational physiotherapy, which will combine therapeutic exercise with a pain education program,
Other: therapeutic-educational physiotherapy and pain education program
They will receive the pain education program.
Other: pain education program
The EG will carry out a total of 24 sessions, at a rate of 3 weekly sessions of 30 minutes each. The first session of each month will be in person and the rest will be done at home following video tutorials with an App (https://fisiotrack.com). The face-to-face sessions will be conducted by a women's health physiotherapist, and will consist on therapeutic exercises based on body awareness, motor control and respiratory awareness.They will also receive a pain education program with indications on pain education, as well as basic information and general advice on the positive effects of physical activity and a healthy lifestyle for endometriosis. In addition, biweekly supervision will be carried out via telephone or video conference by a specialized physiotherapist.
They will receive instructions on pain education, as well as basic information and general advice about the positive effects of physical activity and a healthy lifestyle for your endometriosis, in writing via email. In addition, they will receive biweekly supervision via telephone or video conference by a specialized physical therapist.
Musculoskeletal pain - Pressure pain threshold
Pressure pain threshold measured in rectus abdominis and lumbar muscles
Time frame: 3 assessent times: T1(pre-intervention), T2 (after 8 weeks intervention), T3 (after 16 weeks intervention)
Musculoskeletal pain - quantitative Sensory Testing
Quantitative sensory testing is a non-invasive technique used to assess and quantify sensory functions by determining sensation and pain thresholds using pressure.
Time frame: 3 assessent times: T1(pre-intervention), T2 (after 8 weeks intervention), T3 (after 16 weeks intervention)
Musculoskeletal pain - pain drawing
Identification of pain areas through a pain map: this consists of a human figure on a two-dimensional plane on which the patient can express the representation of the pain areas on a schematic of the body surface.
Time frame: 3 assessent times: T1(pre-intervention), T2 (after 8 weeks intervention), T3 (after 16 weeks intervention)
Musculoskeletal pain - Central Sensitisation Inventory
Central Sensitisation Inventory: is a self-report instrument that indirectly assesses somatic and emotional symptoms that have been found to be associated with Central Sensitisation.
Time frame: 3 assessent times: T1(pre-intervention), T2 (after 8 weeks intervention), T3 (after 16 weeks intervention)
Physical-Funcionality - Hand grip Strength
Hand grip strength will be measured by the handgrip strength technique using a Jamar Plus+ digital hand dynamometer.
Time frame: 3 assessent times: T1(pre-intervention), T2 (after 8 weeks intervention), T3 (after 16 weeks intervention)
Physical-Funcionality - functional performance
To assess functional performance patients will be instructed to cross their arms over their chest and complete as many standing cycles as possible in 30 s (30 second- Sit to stand).
Time frame: 3 assessent times: T1(pre-intervention), T2 (after 8 weeks intervention), T3 (after 16 weeks intervention)
Physical-Funcionality- Pelvic floor Dynamometry
Dynamometry of the pelvic floor muscles: measurement of basal tone (g) and tone at maximum contraction (Phenix Liberty Dynamometer).
Time frame: 3 assessent times: T1(pre-intervention), T2 (after 8 weeks intervention), T3 (after 16 weeks intervention)
Physical-Funcionality - Body composition
Body composition (% fat, % water, % muscle): record body composition (skeletal muscle mass and % body fat) with a bioimpedance scale (DC-430MA, Tanita Corporation of America, Inc, Arlignton Heights, IL, USA).
Time frame: 3 assessent times: T1(pre-intervention), T2 (after 8 weeks intervention), T3 (after 16 weeks intervention)
Physical-Funcionality - Motor control
Determine motor control: clinical test of lumpopelvic and thoracolumbar dissociation will be used.
Time frame: assessent times: T1(pre-intervention), T2 (after 8 weeks intervention), T3 (after 16 weeks intervention)
Physical-Funcionality - Lumbar spine flexibility
Lumbar spine flexibility: It will be measured with the Schöber test
Time frame: assessent times: T1(pre-intervention), T2 (after 8 weeks intervention), T3 (after 16 weeks intervention)
Physical-Funcionality - Catastrophyzing
Catastrophyzing: to assess catastrophic thinking related to pain the Pain Catastrophyzing Scale (PCS) will be used
Time frame: assessent times: T1(pre-intervention), T2 (after 8 weeks intervention), T3 (after 16 weeks intervention)
Physical-Funcionality - Kinesophobia
Kinesophobia: it will be assessed with the Tampa Scale for Kinesophobia-11 (TSK-11), which consists of 11 items.
Time frame: assessent times: T1(pre-intervention), T2 (after 8 weeks intervention), T3 (after 16 weeks intervention)
Quality of Life - Endometriosis
Quality of life will be assessed using the Spanish version of the Endometriosis Health Profile-30 (EHP-30).
Time frame: assessent times: T1(pre-intervention), T2 (after 8 weeks intervention), T3 (after 16 weeks intervention)
Quality of Life - Gastrointestinal
Quality of life at the gastrointestinal level will be assessed using the Gastrointestinal Quality of Life Index, which addresses 5 domains (digestive symptoms, physical state, emotions, social dysfunction and effects of medical treatment).
Time frame: assessent times: T1(pre-intervention), T2 (after 8 weeks intervention), T3 (after 16 weeks intervention)
Quality of Life - Sexual Function
the abbreviated Index of Female Sexual Function (IFSF-6) will be used. It is a multidimensional self-reported instrument for the evaluation of female sexual function
Time frame: assessent times: T1(pre-intervention), T2 (after 8 weeks intervention), T3 (after 16 weeks intervention)
Quality of Life - Stress
Stress using the Perceived stress scale (PSQ).
Time frame: assessent times: T1(pre-intervention), T2 (after 8 weeks intervention), T3 (after 16 weeks intervention)
Biomarkers - Inflamation
Plasma markers of chronic inflammation and intestinal permeability will be assessed including a multiplex array of inflammation markers, and as specific markers of chronic inflammation associated with intestinal permeability, zonulin, C-reactive protein, Binding Protein , and bactericidal/permeability-increasing protein will be assessed.
Time frame: assessent times: T1(pre-intervention), T2 (after 8 weeks intervention), T3 (after 16 weeks intervention)
Patient's satisfaction
Satisfaction with the treatment received will be assessed using the Satisfaction with Treatment Received Scale (CRES-4).
Time frame: assessent times: T2 (after 8 weeks intervention), T3 (after 16 weeks intervention)
Patient's perception of change
Patient's Perception of change after the treatment will be measured by patients' global impression of change (PGIC) in a quantitative and qualitative way.
Time frame: assessent times: T2 (after 8 weeks intervention), T3 (after 16 weeks intervention)
APP usability
A questionnaire on the usability of the application will be used. System Usability Scale.
Time frame: assessent times: T2 (after 8 weeks intervention), T3 (after 16 weeks intervention)
Adherence to treatment
Adherence to treatment: in the experimental group it will be measured through the records made in the application https://fisiotrack.com/, in the control group it will be measured through an ad hoc activity diary that will be provided to them.
Time frame: assessent times: T2 (after 8 weeks intervention), T3 (after 16 weeks intervention)
Plan to share: No
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