An interventional study of Early feeding with an oral diet in Diabetes Mellitus and Diabetic Ketoacidosis, sponsored by Texas Tech University Health Sciences Center. Completed at 1 site in United States. Open to participants aged 18 Years to 89 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-09-11.
Sponsored by Texas Tech University Health Sciences Center · Not applicable, Interventional, and Supportive care
Diabetic ketoacidosis (DKA) and hyperosmolar hyperglycemic state (HHS) are common, but serious metabolic disorders are often encountered in intensive care. In the intensive care setting, it is common to withhold food from patients during treatment of DKA. However, there is no evidence or current literature supporting this practice. The following proposed research investigates the initiation of an early diet versus withholding food during the treatment of diabetic ketoacidosis.
10,925 studies on the registry are indexed under Diabetes Mellitus; 1,318 are open to participants now.
This study's enrollment of 93 is above the median of 80 across 8,367 interventional studies indexed under Diabetes Mellitus.
Browse Diabetes Mellitus studies →Texas Tech University Health Sciences Center is the lead sponsor of 97 studies on the registry; 13 are open to participants now.
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Exclusion Criteria:
If randomized to the experimental group, patient's diet will be advanced to clear liquid for the first day. On the second day, diet will be advanced to full liquid and advanced up to oral (carb controlled 1600 calories) diet as tolerated.
Other: Early feeding with an oral diet
Patient will be kept without PO intake until they are bridged from the insulin drip
Participants in the treatment arm will be initiated on a clear liquid diet on day 1 of medical ICU admission. Diet will be progressed on day 2 to full liquid diet or diabetic diet as patient tolerates based on which diet the patient would prefer.
Resolution of DKA
Defined as a closed anion gap. Adjusted Anion Gap defined as (Blood Sodium - Blood Chloride - Blood Bicarbonate) + 0.25 x ((normal albumin (4.0)) x (observed albumin)); Elevated Anion Gap is \>12
Time frame: Typically resolution of DKA is 24-72 hours, may be up to 5 days in some patients
Length of stay in the medical intensive care unit (in days).
The time from admission order is placed to the time the transfer to another unit order is placed
Time frame: Days (Typically 3-5 days in the MICU, may be up to 1 week).
Length of stay in the hospital
from admission order time to the discharge order time
Time frame: 3-7 days, may be up to 1-2 weeks.
mortality
If patient passes away within 30 days of participating in the study
Time frame: 30 day
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Plan to share: Undecided
This study is completed, as verified in Sep 2026. You cannot join it, but the record below documents what was studied.
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Texas Tech University Health Sciences Center