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CompletedNCT06170216Updated Sep 3, 2026

Different Immunochemotherapies in Small B-cell Non-Hodgkin Lymphoma (iNHL)

An observational study in Lymphoma, Non-Hodgkin, sponsored by Fudan University. Completed at 1 site in China. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-09-03.

Sponsored by Fudan University · Observational

Study type
Observational
Model
Case-only
Time perspective
Prospective
Enrollment
206
Ages
18 Years and older
Sex
All
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Study summary

Describe the application status of different immunochemotherapies in small B-cell non-Hodgkin lymphoma (iNHL), observe the therapeutic efficacy and safety of the treatment modalities.

Read the detailed description

Evaluated the efficacy and safety of different immunochemotherapies in small B-cell non-Hodgkin lymphoma (iNHL)

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Conditions studied

  • Lymphoma, Non-Hodgkin
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In context

Lymphoma, Non-Hodgkin

1,989 studies on the registry are indexed under Lymphoma, Non-Hodgkin; 307 are open to participants now.

This study's enrollment of 206 is above the median of 150 across 159 observational studies indexed under Lymphoma, Non-Hodgkin.

Browse Lymphoma, Non-Hodgkin studies →

Lead sponsor

Fudan University is the lead sponsor of 1,270 studies on the registry; 623 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

Eligibale patients who ≥ 18 years old, Initial or first recurrent iNHL, with no contraindications to any medication in the treatment plan are enrolled. They will sign an informed consent form. Pregnant or lactating women were excluded. And patients who may not benefit from receiving immunochemotherapy evaluated by researchers are also excluded.

Inclusion criteria

  • Age ≥ 18 years old
  • Initial or first recurrent iNHL confirmed by histopathology, including FL (1-3a), MZL, MCL;
  • Sign an informed consent form;
  • Researchers evaluate patients who can benefit from receiving immunochemotherapy.

Exclusion criteria

Exclusion Criteria:

  • There are contraindications to any medication in the treatment plan;
  • Pregnant or lactating women or male and female participants of childbearing age did not take contraceptive measures during the trial period and within 30 days after the last medication;
  • Researchers believe that patients who are not suitable for enrollment.
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Study design

Observational model
Case-only
Time perspective
Prospective
Enrollment
206 participants (actual)
Patient registry
No

Groups and cohorts

  • small B-cell non-Hodgkin lymphoma

    Different immunochemotherapies in small B-cell non-Hodgkin lymphoma

    Drug: immunochemotherapies

Interventions

  • Drugimmunochemotherapies

    Observing different immunochemotherapies in small B-cell non-Hodgkin lymphoma (iNHL), which are chosen by investigators, such as RCHOP, BR, RCVP, etc.

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What researchers measure

Primary outcomes

  1. ORR

    the ratio of numbers of patients with complete response and partial response to all the participants receiving treatment

    Time frame: up to 6 months

Secondary outcomes

  1. 2-year progression-free survival (PFS)

    the period from the date of patients sign informed consent to the observed progression of the disease or the occurrence of death for any reason

    Time frame: From date of patients sign informed consent until the date of first documented progression or date of death from any cause, whichever came first, assessed up to 2 years

  2. 2-year event-free survival (EFS)

    the period from the date of patients sign informed consent to the observed event for any reason

    Time frame: From date of patients sign informed consent until the date of first documented event, progression or date of death from any cause, whichever came first, assessed up to 2 years

  3. overall survival

    time between the date of patients sign informed consent and the date of death or the date of last follow-up time

    Time frame: From date of patients sign informed consent until the date of death or the date of last follow-up time, whichever came first, assessed up to 2 years

  4. Hematology and non hematology toxicity

    number of participants with treatment-related adverse events as assessed by CTCAE v5.0

    Time frame: Throughout the treatment period,up to 6 months

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Study locations

1 site
  • Fudan University Shanghai Cancer Center
    Shanghai, Shanghai Municipality 200032, China
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References and documents

Individual participant data

Plan to share: Undecided

No publications or documents are linked to this record.

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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Sep 3, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT06170216
Lead sponsor
Fudan University
Responsible party
Yizhen Liu (Clinical Professor, Fudan University) — Principal investigator
First posted
Dec 14, 2023
Start date
Jan 10, 2023
Primary completion
Dec 19, 2023
Completion
Jan 10, 2026
Last update
Sep 3, 2026

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Sep 2026. You cannot join it, but the record below documents what was studied.

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