An observational study in Burn Unspecified Degree and Deep Sedation, sponsored by T.C. Sağlık Bakanlığı Ankara Bilkent Şehir Hastanesi. Completed at 1 site in Turkey. Open to participants aged 18 Years to 65 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2023-12-12.
Sponsored by T.C. Sağlık Bakanlığı Ankara Bilkent Şehir Hastanesi · Observational
Adequate and effective pain management and prevention of depression are essential in burn patients. This study aims to investigate the effects of ketamine sedation in burn patients in terms of mood disorders, depression, anxiety, and suicidal tendency during intensive care follow-up in the postoperative period.
Aim: Adequate and effective pain management and prevention of depression are essential in burn patients. This study aims to investigate the effects of ketamine sedation in burn patients in terms of mood disorders, depression, anxiety, and suicidal tendency during intensive care follow-up in the postoperative period.
Methods: The study was conducted with 67 patients between 18 and 65 years of age, who were ASA I-II class, had basic communication skills, no previous diagnosis of psychiatric illness, and no history of neuropsychiatric or cognitive disease or related treatment. After preoxygenation, anesthesia induction was performed with 2 mg/kg IV propofol and 1 mcg/kg IV fentanyl in the general anesthesia group. Anesthesia was continued with a mixture of 0.3-0.5 mcg/kg/min remifentanil, 2% sevoflurane, 50% air, 50% oxygen. In the sedation group, 1 mcg/kg IV fentanyl and 1 mg/kg IV ketamine were administered at induction; anesthesia was maintained by adding 30-50 mg IV propofol if necessary. The Montgomery-Asberg Depression Rating Scale (MADRS), the Hamilton Anxiety Rating Scale (HAM-A), and the Beck Scale for Suicide Ideation (BSSI) were administered preoperatively and on postoperative day one by the psychiatrist.
719 studies on the registry are indexed under Burns; 145 are open to participants now.
This study's enrollment of 67 is above the median of 55 across 135 observational studies indexed under Burns.
Browse Burns studies →This is the only study on the registry with T.C. Sağlık Bakanlığı Ankara Bilkent Şehir Hastanesi as lead sponsor.
Counted across the registry records on this site, refreshed daily.
Patients of both sexes aged 18 to 65 years will be included in the study.
Exclusion Criteria:
After preoxygenation, anesthesia induction was performed with 2 mg/kg IV propofol and 1 mcg/kg IV fentanyl in the general anesthesia group. Anesthesia was maintained with a mixture of 0.3-0.5 mcg/kg/min remifentanil, 2% sevoflurane, 50% air, 50% oxygen. The Montgomery-Asberg Depression Rating Scale (MADRS), the Hamilton Anxiety Rating Scale (HAM-A), and the Beck Scale for Suicide Ideation (BSSI) were administered preoperatively and on postoperative day one by a psychiatrist.
In the sedation group, 1 mcg/kg IV fentanyl and 1 mg/kg IV ketamine were administered at induction, and 30-50 mg IV propofol was added if necessary to maintain anesthesia. The Montgomery-Asberg Depression Rating Scale (MADRS), the Hamilton Anxiety Rating Scale (HAM-A), and the Beck Scale for Suicide Ideation (BSSI) were administered preoperatively and on postoperative day one by a psychiatrist.
Montgomery-Asberg Depression Rating Scale (MADRS),
In order to determine whether there is negative mood and depression; Montgomery-Asberg Depression Rating Scale (MADRS) was administered by the psychiatrist .
Time frame: 72 hours
Hamilton Anxiety Rating Scale (HAM-A)
For anxiety; Hamilton Anxiety Rating Scale (HAM-A) was administered by the psychiatrist .
Time frame: 72 hours
Beck Suicidal Ideation Scale (BSSI)
To determine whether there is suicidal ideation; Beck Suicidal Ideation Scale (BSSI) was administered by the psychiatrist .
Time frame: 72 hours
Plan to share: Yes — IPD will be shared with other researchers.
Supporting information: Study protocol, Sap
This study is completed, as verified in Dec 2023. You cannot join it, but the record below documents what was studied.
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