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CompletedNCT06165835Updated Apr 3, 2025

Study on Post-Acute COVID-19 Syndrome in Improvement of COVID-19 Rehabilitated Patients by Respiratory Training

An interventional study of breathing training in COVID-19, Post-Acute COVID-19 Syndrome and Dyspnea, sponsored by Tri-Service General Hospital. Completed at 1 site in Taiwan. Open to participants aged 20 Years to 90 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2025-04-03.

Sponsored by Tri-Service General Hospital · Not applicable, Interventional, and Treatment

From the registry’s dates

  • Registered 5 months after the study started (first participant enrolled Jul 2023, registered Dec 2023).
Phase
Not applicable
Study type
Interventional
Enrollment
90
Allocation
Randomized
Ages
20 Years to 90 Years
Sex
All
01

Study summary

Since the emergence of Corona Virus Disease 2019(COVID-19), it has spread rapidly around the world, And it has had a profound impact on the lives and health of people around the world, most of the COVID-19 positive patients are 3-4 weeks after the onset of infection patients can turn negative and recover, however, increasing observational data suggest that these patients long-term or recurring symptoms such as: fatigue, palpitations, cognitive impairment, dyspnea, anxiety, chest tightness and Pain, etc., symptoms may last at least two months or even longer (for example, up to 12 months), the patient's quality of life and The ability to work and social activities also decline accordingly. Therefore, in addition to the acute symptoms after infection, patients also face the same. The challenge of long-term health sequelae associated with COVID-19.

Read the detailed description

Relevant studies have shown that breathing training can improve the exercise capacity, lung function, and respiratory rate of patients who have recovered from COVID-19. Difficult and other aspects are safe and effective. However, because COVID-19 is an emerging disease, the clinical research literature so far has limited Clinical data are still insufficient, and the effect of respiratory training on the breathing and physical function of COVID-19 patients has not been determined, and most of the patients are not living in the hospital. How to carry out simple and effective breathing training to reduce the long-term impact of COVID-19 on patients is worthy of continuous discussion. This study will assist COVID-19 patients to perform respiratory training with incentive spirometer intervention, and collect patients before and after the intervention Oxygen requirements, blood draw values and Post-COVID-19 Functional Status scale(PCFS scale) and other data to explore and evaluate the effect of interventional breathing training on the improvement of symptoms of new coronary pneumonia, as a reference for future clinical treatment and improvement of symptoms of COVID-19.

02

Conditions studied

  • COVID-19
  • Post-Acute COVID-19 Syndrome
  • Dyspnea
  • Incentive Spirometer
03

In context

COVID-19

7,638 studies on the registry are indexed under COVID-19; 488 are open to participants now.

This study's enrollment of 90 is close to the median of 100 across 4,098 interventional studies indexed under COVID-19.

Browse COVID-19 studies →

Lead sponsor

Tri-Service General Hospital is the lead sponsor of 110 studies on the registry; 11 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
20 Years to 90 Years
Sexes eligible
All
Accepts healthy volunteers
Yes

Inclusion criteria

  1. Patients who have recovered from COVID-19

Exclusion criteria

Exclusion Criteria:

  1. Have suffered from within one year. Those who have recovered from COVID-19 must present proof of diagnosis, such as a medical certificate or screening results, etc., and ICD10 when seeking medical treatment The diagnostic codes are: U07.1 Confirmed COVID-19 virus infection, U09.0 Severe specific infectious pneumonia (COVID-19), unspecified.
  2. adult, aged 20-90
  3. conscious mind and behavior normal mental state examination (Mini-Mental State Examination, MMSE) score > 21 points.
  4. Those who can communicate in verbal or non-verbal ways and understand Chinese and Taiwanese.
  5. are willing to participate in the research and agree to accept random machine dispatcher
05

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
None (open label)
Enrollment
90 participants (actual)

Study arms

  • No intervention
    Experimental

    Patients who have recovered from COVID-19

  • Experimental
    Three months after recovering from COVID-19

    Patients who have from COVID-19 in three months

    Device: breathing training

  • Experimental
    Six months after recovering from COVID-19

    Patients who have from COVID-19 in three to six months

    Device: breathing training

  • Experimental
    Nine months after recovering from COVID-19

    Patients who have from COVID-19 in six to nine months

    Device: breathing training

  • Experimental
    Twelve months after recovering from COVID-19

    Patients who have from COVID-19 in nine to twelve months

    Device: breathing training

Interventions

  • Devicebreathing training

    Breathing training for six weeks.

    Also known as: Incentive Spirometer

06

What researchers measure

Primary outcomes

  1. Oxygen requirements, blood draw values

    Oxygen requirements, blood draw values

    Time frame: 6 WEEKS

07

Study locations

1 site
  • Tri Service General Hospital Sonshan Branch
    Taipei City, 105309, Taiwan
08

References and documents

Individual participant data

Plan to share: Undecided

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Apr 3, 2025, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT06165835
Lead sponsor
Tri-Service General Hospital
Responsible party
Chen, Yao-Hsiang (assistant hand nurse, Tri-Service General Hospital) — Principal investigator
First posted
Dec 12, 2023
Start date
Jul 1, 2023
Primary completion
Dec 30, 2024
Completion
Dec 30, 2024
Last update
Apr 3, 2025

Study contacts

Yao-Hsiang Chen
principal investigator · Tri Service General Hospital Sonshan Branch

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Mar 2025. You cannot join it, but the record below documents what was studied.

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