An interventional study of PRF in Facial Swelling, Tooth Position Anomalies and Tooth, Impacted, sponsored by Amerigo Giudice. Completed at 1 site in Italy. Open to participants aged 18 Years to 32 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2023-12-11.
Sponsored by Amerigo Giudice · Not applicable, Interventional, and Treatment
The present study aims to analyze the effect of PRF (Platelet-rich-fibrin) in terms of facial swelling, trismus and pain after surgical removal of mandibular third molar (M3M) in a split-mouth randomized controlled clinical trial.
The present study aims to analyze the effect of PRF (Platelet-rich-fibrin) in terms of facial swelling, trismus and pain after surgical removal of mandibular third molar (M3M) in a split-mouth randomized controlled clinical trial. Facial swelling will be assessed using an innovative three-dimensional digital technique.
Exclusion Criteria:
Placement of PRF in the post-extraction socket after third molar surgery
Biological: PRF
No positioning PRF in the post-extraction socket after third molar surgery
Post-operative PRF placement in the post-extraction socket after third molar surgery
Facial swelling qualitative analysis
To compare the effectiveness of PRF in reducing facial swelling using qualitative three-dimensional analysis (measured by colorimetric variation given by the overlapping volumes) .
Time frame: Change from baseline (before surgery) at 2 day after surgery and at 7 days after surgery
Facial swelling quantitative analysis - volumetric differences
To compare the effectiveness of PRF in reducing facial swelling using quantitative three-dimensional analysis ( volumes measured in cm3) .
Time frame: Change from baseline (before surgery) at 2 day after surgery and at 7 days after surgery
Facial swelling quantitative analysis - linear differences
To compare the effectiveness of PRF in reducing facial swelling using quantitative three-dimensional analysis (linear differences measured in cm2) .
Time frame: Change from baseline (before surgery) at 2 day after surgery and at 7 days after surgery
Trismus analysis
To assess the effects of PRF administration on trismus (measured in cm)
Time frame: Change from baseline (before surgery) at 2 day after surgery and at 7 days after surgery
Pain analysis with Visual analogue scale (VAS)
To assess the effects of PRF administration on pain (measured by VAS-score from 0 to 10 point, with 10 as the worst outcome)
Time frame: Change from baseline (before surgery) at 2 day after surgery and at 7 days after surgery
Plan to share: No
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This study is completed, as verified in Dec 2023. You cannot join it, but the record below documents what was studied.
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Amerigo Giudice