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RecruitingNCT06158360Updated Mar 30, 2026

An Observational Study on Postoperative Symptoms After Thyroidectomy (POS-T)

An observational study in Thyroid Cancer, sponsored by Ilsan Cha hospital. Recruiting at 3 sites in South Korea. Open to participants aged 19 Years and older. Per ClinicalTrials.gov, last updated 2026-03-30.

Sponsored by Ilsan Cha hospital · Observational

From the registry’s dates

  • Started Dec 2023; still recruiting 2 years 10 months later.
Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
500
Ages
19 Years and older
Sex
All
01

Study summary

This observational study aimed to evaluate the safety and efficacy of postoperative management in patients with thyroid cancer who received subtotal or total thyroidectomy.

Read the detailed description
  1. Characteristic analysis of improvement in quality of life and symptoms after surgery in cancer patients
  2. Multifaceted symptom evaluation of cancer patients visiting medical institutions
  3. Evaluation of effectiveness and safety of treatment for postoperative symptoms in thyroid cancer patients
  4. Analysis of the effectiveness and prognosis of cancer-related treatment for each patient with cancer
  5. Analysis of prognostic factors for disease-free survival and overall survival of cancer patients

Among adult men and women aged 19 years or older who have been diagnosed with thyroid cancer, who have undergone partial or total thyroidectomy and visited the hospital for postoperative management, the characteristics of the visiting patient, quality of life, characteristics of cancer-related symptoms, and treatment effectiveness, We intend to conduct a prospective observational study to evaluate safety and its relationship with prognosis. In addition, we aim to form the basis for follow-up research through the establishment of an Oriental medicine cancer cohort and database.

02

Conditions studied

  • Thyroid Cancer

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03

In context

Thyroid Neoplasms

802 studies on the registry are indexed under Thyroid Neoplasms; 216 are open to participants now.

This study's planned enrollment of 500 is above the median of 172 across 261 observational studies indexed under Thyroid Neoplasms.

Browse Thyroid Neoplasms studies →

Lead sponsor

Ilsan Cha hospital is the lead sponsor of 8 studies on the registry; 5 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
19 Years and older
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

Patients who have been diagnosed with thyroid cancer (KCD C73) according to the ICD-10 International Classification of Diseases and have been recommended for postoperative management treatment by a physician or acupuncturist

Inclusion criteria

  • 19 years of age or older
  • Those who have been confirmed to have a malignant tumor of the thyroid gland by biopsy or imaging
  • Subjects who have undergone partial thyroidectomy or total resection within 1 month
  • Those who have agreed to the implementation of Chinese medicine treatment
  • The Eastern Cooperative Oncology Group(ECOG) performance status 0-3
  • Those who understand the content of the study and agree to participate in the study

Exclusion criteria

Exclusion Criteria:

  • ○ When it is judged that other diseases other than cancer (dementia, cerebrovascular disease, severe organ failure, etc.) may have a significant effect on the decline of physical function

    • When it is judged that the life expectancy is less than 3 months and sufficient follow-up cannot be carried out
    • When emergency or major surgery or surgical intervention is required that takes precedence over postoperative treatment
    • Pregnant and lactating women
    • Other researchers who are judged to be unsuitable for research
05

Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
500 participants (estimated)
Patient registry
No
Biospecimen retention
Samples with dna
06

What researchers measure

Primary outcomes

  1. THYCA-QoL score at the time of discharge (1w) of hospitalization performed for postoperative management purposes

    The THYCA-QoL is a health-related quality of life questionnaire developed for thyroid cancer and thyroid cancer survivors using methodologically proven standard guidelines and validated questionnaires to improve symptoms, treatment, follow-up and disease experience in thyThe THYCA-QoL is a health-related quality of life questionnaire developed for thyroid cancer and thyroid cancer survivors using methodologically proven standard guidelines and validated questionnaires to improve symptoms, treatment, follow-up and disease experience in thyroid cancer survivors. roid cancer survivors.

    Time frame: At the end of week 1(each cycle is 7days)

Secondary outcomes

  1. Change in THYCA-QoL over time series

    The THYCA-QoL is a health-related quality of life questionnaire developed for thyroid cancer and thyroid cancer survivors using methodologically proven standard guidelines and validated questionnaires to improve symptoms, treatment, follow-up and disease experience in thyThe THYCA-QoL is a health-related quality of life questionnaire developed for thyroid cancer and thyroid cancer survivors using methodologically proven standard guidelines and validated questionnaires to improve symptoms, treatment, follow-up and disease experience in thyroid cancer survivors. roid cancer survivors.

    Time frame: At the end of Day 1, week 1, week 2, 1 month, 2 month, 3 month, 4 month, 6 month, 12 month

  2. EORTC-QLQ-C30

    It is a health-related questionnaire for cancer patients. It consists of 3 subdomains: overall quality of life, functional area, and symptom domain, a total of 30 items.

    Time frame: At the end of Day 1, week 1, week 2, 1 month, 2 month, 3 month, 4 month, 6 month, 12 month

  3. BCQ

    It is a dialectic tool that divides the physiological and pathological conditions and symptoms of the human body into three dialectics: concession, yinhe, and word-body, and identifies the deteriorated condition of the human body.

    Time frame: At the end of Day 1, week 1, week 2

  4. CHPIQ

    It is a key diagnostic technology that plays a decisive role in the selection of prescriptions in traditional Chinese medicine, and it is a symptom-based cold and heat pattern identification questionnaire that has been recognized for its reliability and validity. CHPIQ).

    Time frame: At the end of Day 1, week 1, week 2

  5. MDASI-Core

    The MDASI-core is a 19-item questionnaire that identifies pain, fatigue, nausea, vomiting, insomnia, shortness of breath, cognitive function, anorexia and dysthymia on a 10-point scale.

    Time frame: At the end of Day 1, week 1, week 2, 1 month, 2 month, 3 month, 4 month, 6 month, 12 month

  6. Oral epithelial cell-based whole genome analysis

    The Asia PMRA chip contains more than 300 cancer-related common variants and 2,600 rare variants as well as 2,600 pharmacogenomic-related variants, including more than 300 cancer-related common variants and 2,600 rare variants contained in the ClinVar (\> 43,000 markers) or GWAS Catalog (\> 23,400 markers), which are databases for diseases and various traits.

    Time frame: Day 1

  7. overall survival

    To investigate the overall survival of study subjects enrolled in the study and cancer-related deaths, from the time of initiation of cancer-related TCM treatment to death.

    Time frame: At the end of Day 1, week 1, week 2, 1 month, 2 month, 3 month, 4 month, 6 month, 12 month

  8. Adverse events

    CTCAE ver. To investigate the types and incidence of adverse events in accordance with 5.0.

    Time frame: At the end of Day 1, week 1, week 2, 1 month, 2 month, 3 month, 4 month, 6 month, 12 month

07

Study locations

3 of 3 sites recruiting
  • Bundang Cha Hospital
    Gyeonggi-do, South Korea
    Recruiting
  • Ilsan Cha Hospital
    Gyeonggi-do, South Korea
    Recruiting
  • Gangnam Cha Hospital
    Seoul, South Korea
    Recruiting
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Mar 30, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT06158360
Lead sponsor
Ilsan Cha hospital
Responsible party
Jee Young Lee (Assistant professor, CHA University) — Principal investigator
First posted
Dec 6, 2023
Start date
Dec 1, 2023
Primary completion
Dec 31, 2029 (estimated)
Completion
Dec 31, 2029 (estimated)
Last update
Mar 30, 2026

Study contacts

Jee Youg Lee
Contact
happiade@chamc.co.kr
082-31-782-3113
Jee Youg Lee
principal investigator · Ilsan Cha hospital

Oversight

Data monitoring committee
Yes
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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