An interventional study of pain education and mindfulness of pain introduction and intervention in Endometriosis, Pain and Mindfulness, sponsored by Milton S. Hershey Medical Center. Recruiting at 1 site in United States. Open to female participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-09-29.
Sponsored by Milton S. Hershey Medical Center · Not applicable, Interventional, and Health services research
Endometriosis is a common cause of pelvic pain in women which has been historically under-studied and under-diagnosed. The goal of this research is to pilot-test the feasibility and acceptability of a manualized, single-session brief mindfulness-based intervention (BMBI) among participants with endometriosis-related chronic pelvic pain (ECPP) who undergo surgical treatment, and gather preliminary data necessary for future studies assessing BMBI's impact on outcomes in surgically-treated ECPP. This pilot study will enroll 10-20 adult participants with ECPP to receive either a BMBI adjunctive to treatment as usual (TAU; n=5-10) or education with TAU (n=5-10) prior to their ECPP surgery. The central hypothesis is the BMBI is feasible to deliver pre-operatively, acceptable to patients, and may help improve acute post-surgical outcomes through more adaptive stress coping and pain processing, enabled by mindfulness training.
Exclusion Criteria:
Behavioral: pain education
Behavioral: mindfulness of pain introduction and intervention
Pain education
Brief mindfulness of pain introduction and intervention
Use of opioid medication
Morphine milligram equivalent following surgery
Time frame: 1 week
Use of opioid medication
Morphine milligram equivalent following surgery
Time frame: 3 months
Pain intensity
Numerical Pain Rating Scale 0-10, 10 being highest
Time frame: 1 week
Pain intensity
Numerical Pain Rating Scale 0-10, 10 being highest
Time frame: 3 months
Sleep quality (sleep duration, awakenings, efficiency)
actigraphy monitoring
Time frame: 1 week prior to surgery
Sleep quality (sleep duration, awakenings, efficiency)
actigraphy monitoring
Time frame: 1 week following surgery
Sleep report
sleep diary (hours slept, activities during day and night)
Time frame: 1 week following surgery
Sleep report
sleep diary (hours slept, activities during day and night)
Time frame: 1 week prior to surgery
Emotional functioning
Hospital Anxiety and Depression Scale 0-21, 21 is worst
Time frame: baseline
Emotional functioning
Hospital Anxiety and Depression Scale 0-21, 21 is worst
Time frame: 1 week
Emotional functioning
Hospital Anxiety and Depression Scale 0-21, 21 is worst
Time frame: 3 months
Patient global impression of change
Global Impression of change 1-7, 1 is best
Time frame: 3 months
Patient global impression of change
Global Impression of change 1-7, 1 is best
Time frame: 1 week
Pain catastrophizing
Pain catastrophizing Scale 0-52, 52 is worst
Time frame: baseline
Pain catastrophizing
Pain catastrophizing Scale 0-52, 52 is worst
Time frame: 1 week
Pain catastrophizing
Pain catastrophizing Scale 0-52, 52 is worst
Time frame: 3 months
Treatment satisfaction
Treatment satisfaction 0-10, 10 being best
Time frame: 1 week
Treatment satisfaction
Treatment satisfaction 0-10, 10 being best
Time frame: 3 months
Heart rate variability
brief HRV assessment baseline and during intervention
Time frame: baseline
Pain threshold
Pain threshold
Time frame: baseline
Temporal summation
Temporal summation of pain
Time frame: baseline
Plan to share: No
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Milton S. Hershey Medical Center