An interventional study of High-definition transcranial direct current (HD-tDCS), active condition and High-definition transcranial direct current (HD-tDCS), sham condition in Aphasia, sponsored by Hôpital le Vinatier. Recruiting at 1 site in France. Open to participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2025-07-24.
Sponsored by Hôpital le Vinatier · Not applicable, Interventional, and Basic science
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Among 15 studies in Aphasia with a site in France — 4 open to participants now, 4 under way, none of them phase 3. Aphasia · France.
Among the 15 studies in Aphasia with a site in France, this one is the 3rd largest by planned enrollment of the 10 interventional ones that give a count, is the only one that started in 2024, is one of 9 with no phase, and was the 13th registered.
338 studies on the registry are indexed under Aphasia; 94 are open to participants now.
Browse Aphasia studies →4 of the 15 studies in Aphasia with a site in France are open now. Recruiting first, the newest first:
University Hospital, Toulouse · Sites in France
Ages 18+
Assistance Publique - Hôpitaux de Paris · Sites in France
Ages 18–85
University Hospital, Toulouse · Sites in France
Ages 18–65
A study can be open while its sites in France have not opened yet or have stopped. Only those recruiting at a site in France →
Of the 67 Aphasia studies recruiting now, 30 (45%) set no upper age limit and 11 (16%) stop at 75 or younger; 1 takes children under 18; 16 take healthy volunteers.
This study: 18 Years and older · all sexes · healthy volunteers too.
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15 studies; the count open now beside each. This study's row is marked.
First in 1998; this study’s year is marked. 1 started in 2024.
This study's planned enrollment of 40 is above the median of 30 across 298 interventional studies indexed under Aphasia.
Median enrollment 22 across the 10 interventional studies, 152 across the 5 observational. Of the 9 that completed or were terminated, 1 (11%) have results posted.
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1 of 15 have an industry lead sponsor. The 10 most frequent:
Hôpital le Vinatier is the lead sponsor of 106 studies on the registry; 41 are open to participants now.
Hôpital le Vinatier has 1 study filed under Aphasia — fewer than ten, so there is no comparison to draw.
1 of the studies in Aphasia with a site in France that are under way reach primary completion within a year, 0 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT06140940Hôpital le VinatierMotor Imagery in Aphantasia | 2027-01-01 |
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Among the 15 studies in Aphasia with a site in France, from their registry updates:
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The present study aims to characterize and modulate motor imagery abilities in individuals with aphantasia. The investigators will characterize the neurophysiological and physiological underpinnings of mental imagery abilities in participants with aphantasia by investigating several indices of motor imagery abilities and comparing them to participants with typical mental imagery abilities. The investigators will investigate whether non-invasive brain stimulation applied to the primary motor cortex improves mental imagery abilities in participants with aphantasia.
The investigators will recruit 20 participants with aphantasia and 20 participants with typical mental imagery capacities (no-aphantasia groups). Participants in both groups will complete a 3-hour visit for inclusion and baseline measurements (Visit 1) which will include neurophysiological, autonomic nervous system, cognitive and behavioral measures.
Participants in the aphantasia group will complete 2 additional visits to receive active and sham tDCS sessions (Visit 2 and 3), according to a randomized, double-blind, sham-controlled, crossover design. Mental training will be done concurrently with tDCS using a sequential finger tapping-task (Truong et al., 2022). Participants will receive the instructions of trying to imagine themselves performing the motor task, by feeling their fingers moving as if they were actually moving it (kinesthetic modality of motor imagery).
Visits will be separated by at least 7 days.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.
Ways of preventing pregnancy. “Highly effective” methods fail less than 1% of the time a year when used correctly — for example an IUD or an implant.
Criteria usually say which methods count and how long to keep using them after the last dose, sometimes for male participants too. Some studies accept a partner’s vasectomy if it was confirmed successful and that person is the participant’s only sexual partner.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Contraindication
A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Contraception
Ways of preventing pregnancy. “Highly effective” methods fail less than 1% of the time a year when used correctly — for example an IUD or an implant.
Criteria usually say which methods count and how long to keep using them after the last dose, sometimes for male participants too. Some studies accept a partner’s vasectomy if it was confirmed successful and that person is the participant’s only sexual partner.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Participants will receive a session of active HD-tDCS at a current intensity of 4 mA for a duration of 15min. The placement of electrodes will be determined to specifically target the primary motor cortex (4 x 1 montage with the anode over C4). During the stimulation, participants will be engaged in a mental training task (sequential finger tapping-task).
Procedure: High-definition transcranial direct current (HD-tDCS), active condition
High-definition transcranial direct current (HD-tDCS), sham condition. Participants will receive a session of sham HD-tDCS, which will be delivered following the same procedures as active HD-tDCS but the intensity of the current will be set at 4mA during the 30 first seconds at the beginning of the 15-min period of the stimulation, and equal to 0 mA for the reminding period of stimulation to simulate the tingling sensation often experienced by individuals during active stimulation. The placement of electrodes will be determined to specifically target the primary motor cortex (4 x 1 montage with the anode over C4). During the stimulation, participants will be engaged in a mental training task (sequential finger tapping-task).
Procedure: High-definition transcranial direct current (HD-tDCS), sham condition
Participants will receive a session of active HD-tDCS at a current intensity of 4 mA for a duration of 15min. The placement of electrodes will be determined to specifically target the primary motor cortex (4 x 1 montage with the anode over C4). During the stimulation, participants will be engaged in a mental training task (sequential finger tapping-task).
Participants will receive a session of sham HD-tDCS, which will be delivered following the same procedures as active HD-tDCS but the intensity of the current will be set at 4mA during the 30 first seconds at the beginning of the 15-min period of the stimulation, and equal to 0 mA for the reminding period of stimulation to simulate the tingling sensation often experienced by individuals during active stimulation. The placement of electrodes will be determined to specifically target the primary motor cortex (4 x 1 montage with the anode over C4). During the stimulation, participants will be engaged in a mental training task (sequential finger tapping-task).
Gains in motor performance following mental training
Gains in motor performance following mental training combined with tDCS will be measured using a sequential finger tapping-task. Gains following training will be expressed as a percentage of the baseline performance.
Time frame: 2 times: immediately before tDCS (baseline) and immediately after tDCS
Motor corticospinal excitability at rest and during kinesthetic motor imagery
Motor corticospinal excitability will be assessed with single-pulse transcranial magnetic stimulation (TMS) applied over the primary motor cortex representation of the non-dominant hand. Using electromyography, we will measure the peak-to-peak mean amplitude of motor evoked potentials (MEPs, measured in mV) in the contralateral first dorsal interosseous muscle both at rest and during kinesthetic motor imagery.
Time frame: 1 time at baseline (Visit 1), in both groups
Heart rate variability
Heart rate variability, including respiratory sinus arrhythmia measures, expressed in milliseconds (ms), will be assessed at rest and during kinesthetic motor imagery by recording the heart rate using three electrodes placed in the left chest area. These electrodes will be connected to the Biopac MP150 system and monitored with the Acqknowledge software
Time frame: through study completion, an average of 1 month
Skin conductance
Amplitude of electrodermal response will be measured at rest, during actual movements and during kinesthetic motor imagery using the Biopac MP150 system with the Acqknowledge software. The ratio between amplitudes during imagined/actual movements will be computed (expressed in percent).
Time frame: through study completion, an average of 1 month
Mental imagery abilities
Mental imagery abilities in different sensory modalities will be measured as scores at the following questionnaires: Vividness of Visual Imagery Questionnaire (VVIQ; range 16-80)
Time frame: 1 time at baseline, in both groups
Mental imagery abilities
Mental imagery abilities in different sensory modalities will be measured as scores at the following questionnaires: the Kinesthetic and Visual Imagery Questionnaire (KVIQ; range 20-100).
Time frame: 1 time at baseline, in both groups
Mental imagery abilities
Mental imagery abilities in different sensory modalities will be measured as scores at the following questionnaires: the Movement Imagery Questionnaire-Revised (MIQ-R; range 14-98)
Time frame: 1 time at baseline, in both groups
Mental imagery abilities
Mental imagery abilities in different sensory modalities will be measured as scores at the following questionnaires: the Test of Ability in Movement Imagery (TAMI; range 0-24)
Time frame: 1 time at baseline, in both groups
Mental imagery abilities
Mental imagery abilities in different sensory modalities will be measured as scores at the following questionnaires: Plymouth Sensory Imagery Questionnaire (Psi-Q; range 0-70)
Time frame: 1 time at baseline, in both groups
Source monitoring performance
Source monitoring performance will be evaluated using a specific source monitoring task . Source-monitoring accuracy scores (range 0-100) will be calculated as proportions of accurate source attributions for each source
Time frame: 1 time at baseline, in both groups
Implicit motor imagery capacities
Implicit motor imagery capacities will be measured using a hand laterality judgment task . The percentage of correct response at the task will be calculated (range 0-100%).
Time frame: 1 time at baseline, in both groups
Performance of time-to-contact estimation
Performance will be measured using a specific time-to-contact (TTC) task. A TTC task involves temporal prediction in that the task requires a participant to predict the moment at which an event will occur given past sensory information (e.g., an auditory stimuli). The estimation of TTC requires determining the moment of contact (TTCa). The analysis of performance is based on BIAS quantification, which measures the average difference between individual estimation and TTCa
Time frame: 1 time at baseline, in both groups
Plan to share: No
No publications or documents are linked to this record.
Started Mar 2024 (actual). Primary completion is estimated for Jan 2027, 33 months after the start.
Of 183 non-industry interventional studies with no phase under Aphasia, half reached primary completion within 36 months of starting (the median), counting those still running; a quarter within 19 and three quarters within 57. This study's planned 33 months is close to that.
Counting every sponsor, half of 185 studies reached it within 36 months; a quarter within 19 and three quarters within 57.
How these figures are worked out, and which studies are left out of them.
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