An observational study in Brain Network Connectivity, Postoperative Delirium and Dexmedetomidine, sponsored by Beijing Tiantan Hospital. Recruiting at 1 site in China. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2025-02-14.
Sponsored by Beijing Tiantan Hospital · Observational
Perioperative anesthesia can affect postoperative cognitive function. In our previous study, intraoperative dexmedetomidine (Dex) infusion reduced the incidence of delirium within the first 5 days after brain tumor. However, the mechanism is still unclear. With the development of neuroimaging, multimodal neuroimaging technology provide a new method to explore the underlying mechanism. Therefore, the purpose of this study is to analyze the alterations of brain network under sedation and anesthesia by different anesthetics in patients with supratentorial glioma and their association with cognition.
763 studies on the registry are indexed under Emergence Delirium; 241 are open to participants now.
This study's planned enrollment of 120 is below the median of 164 across 280 observational studies indexed under Emergence Delirium.
Browse Emergence Delirium studies →Beijing Tiantan Hospital is the lead sponsor of 465 studies on the registry; 282 are open to participants now.
Counted across the registry records on this site, refreshed daily.
The population will be selected from patients who schedule to receive elective surgery in Beijing Tiantan Hospital.
Exclusion Criteria:
Participants will be sedated and maintained by dexmedetomidine.
Drug: Dexmedetomidine
Participants will be sedated and maintained by propofol.
Drug: Propofol
Participants will be sedated and maintained by remimazolam.
Drug: Remimazolam Injection
Participants will be sedated and maintained by dexmedetomidine during the surgery.
Participants will be sedated and maintained by propofol during the surgery.
Participants will be sedated and maintained by remimazolam during the surgery.
The alterations of brain network connectivity.
fMRI and DTI will be used to detect brain network connectivity.
Time frame: Before sedation, 30 minutes after sedation，and 30 minutes after surgery.
Postoperative delirium.
The incidence and severity of postoperative delirium and its association with changes of brain network connectivity.
Time frame: Day 1-5 after surgery.
Electroencephalogram changes
Electroencephalogram will be used to record the brain activity.
Time frame: From patients admission to operation room until 10 minutes after surgery
rScO2 changes.
Regional cerebral oxygen saturation (rScO2) will be monitored with near-infrared spectroscopy (NIRS).
Time frame: From patients admission to operation room until 10 minutes after surgery
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Beijing Tiantan Hospital