An interventional study of Arm I (Sarcopenia) and Arm II(Normal) in Knee Osteoarthritis, sponsored by Gangnam Severance Hospital. Recruiting at 1 site in Korea, Republic of. Open to female participants aged 60 Years and older. Per ClinicalTrials.gov, last updated 2024-07-19.
Sponsored by Gangnam Severance Hospital · Not applicable, Interventional, and Treatment
As human life expectancy increases, the prevalence of degenerative osteoarthritis of the knee joints is steadily rising, leading to a significant surge in the frequency of total knee arthroplasty (TKA). However, research on sarcopenia in the population that comprises the primary recipients of these orthopedic joint surgeries has been notably lacking. Since the release of the 2019 Consensus update on sarcopenia by the Asian Walking Group for Sarcopenia (AWGS) in 2020, research on sarcopenia has gained momentum in various domains. Yet, as previously mentioned, the field of orthopedics still lags behind in investigating sarcopenia. Therefore, it is believed that establishing the relationship between sarcopenia and surgical outcomes in the elderly, who are the primary targets of orthopedic joint replacement surgery, could offer insights to further enhance the results of joint replacement surgeries.
1,208 studies on the registry are indexed under Sarcopenia; 402 are open to participants now.
This study's planned enrollment of 150 is above the median of 60 across 775 interventional studies indexed under Sarcopenia.
Browse Sarcopenia studies →Gangnam Severance Hospital is the lead sponsor of 141 studies on the registry; 37 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Patients were categorized into preoperative sarcopenia
Procedure: Arm I (Sarcopenia) · Procedure: Arm II(Normal)
normal groups according to the AWGS 2019 criteria.
Same as standard treatment
Same as standard treatment
handgrip strength, gait speed, SPPB, ASM)
Handgrip strengths were measured using a handgrip dynamometer before surgery. low muscle mass AND (low physical performance OR low strength) : sarcopenia low muscle mass AND (low physical performance AND low strength) : severe sarcopenia
Time frame: 6, 12months after surgery
gait speed
Gait speed was measured using a dedicated camera equipped with LiDAR sensors.
Time frame: 6, 12months after surgery
SPPB
The Short Physical Performance Battery was measured using a dedicated device that included a force plate.
Time frame: 6, 12months after surgery
ASM
Appendicular Skeletal Muscle Mass was measured through Bioelectrical Impedance Analysis.
Time frame: 6, 12months after surgery
Knee Society Score
The original KSS has a "Knee Score" section (7 items) and a "Functional Score" section (3 items). Both sections are scored from 0 to 100 with lower scores being indicative of worse knee conditions and higher scores being indicative of better knee conditions
Time frame: 3, 6, and 12months after surgery
WOMAC
Higher scores indicate worse pain, stiffness, and functional limitations. The WOMAC measures five items for pain (score range 0-20), two for stiffness (score range 0-8), and 17 for functional limitation (score range 0-68).
Time frame: 3, 6, and 12months after surgery
EQ-5D
The EuroQol 5 Dimension (EQ-5D) is a self-report survey that measures quality of life across 5 domains: mobility, self-care, usual activities, pain/discomfort, and anxiety/depression
Time frame: 3, 6, and 12months after surgery
UCLA score
The UCLA Activity Scale (UCLA) is a questionnaire assessing physical activity level from 1 (low) to 10 (high) in patients undergoing hip or knee arthroplasty
Time frame: 3, 6, and 12months after surgery
Plan to share: No
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Gangnam Severance Hospital