An interventional study of TAPB with dexamethasone as an adjuvant to local anesthetics and TAPB with methylprednisolone as an adjuvant to local anesthetics in Local Anesthetic, Ultrasound and Pain, Acute, sponsored by Kasr El Aini Hospital. Completed at 1 site in Egypt. Open to female participants aged 20 Years to 45 Years. Per ClinicalTrials.gov, last updated 2024-04-23.
Sponsored by Kasr El Aini Hospital · Not applicable, Interventional, and Treatment
The aim of this work to compare between the efficacy of ultrasound guided TAP block with dexamethasone as an adjuvant versus ultrasound guided TAPB with methyl prednisolone as an adjuvant to local anesthetic for postoperative pain management in lower abdominal hysterectomy procedures.
Patients will be divided in to two groups; TAPB with dexamethasone as an adjuvant to local anesthetic Gr A(n=25) and TAPB with methyl prednisolone as an adjuvant to local anesthetic Gr B(n=25).
By the end of surgery and with the patient in supine position and after covering of surgery site, preparing the skin with povidone iodine, a high frequency (5-10 MHZ) ultrasound probe (S-NerveTM; SonoSite Inc., Bothell, WA, USA) will be placed transversally on abdominal wall between lower costal margin and iliac crest near midline. After identifying the rectus abdominis muscle, we will gradually move the ultrasound probe laterally to identify the transversus abdominis muscle lying posterior to the rectus muscle. A 22 G echogenic needle using the in plane technique will be inserted medially aiming towards the iliac crest, then 30ml total volume of 0.25 plain bupivacaine 1.5mg/kg with lidocaine 1% 3mg/kg with 8mg dexamethasone in group A patients and 30ml total volume of 0.25 plain bupivacaine 1.5mg/kg with lidocaine 1% 3mg/kg with 50 mg methylprednisolone in group B patients.
Vital signs (H.R and non invasive blood pressure) will be recorded at the onset of the block then every 20 min for an hour then every 4hrs for 12 hrs. post operative
Postoperative:
Paracetamol every 8 hours and ketorolac every 12 hours should be given as a part of multimodal analgesia and nalbuphine given as rescue analgesia and included in secondary outcomes
Post-operative assessment and analgesic regimen
Post operative pain assessment using V.A.S will be assessed (0-10) (11) (as zero refer to no pain and 10 refer to the worst pain) after 1h of the block then every 4hrs for 12 hrs. then every 8hrs for 48 hrs then after 72hrs . The patient will be given Paracetamol every 8 hours and ketorolac every 12 hours The time to the first request of rescue post operative analgesic will be recorded, when the patient complain of pain (V.A.S> 3) intravenous nalbuphine 5mg will be given, total dose of nalbuphine will be recorded /24hrs.
908 studies on the registry are indexed under Acute Pain; 154 are open to participants now.
This study's enrollment of 50 is below the median of 87 across 759 interventional studies indexed under Acute Pain.
Browse Acute Pain studies →Kasr El Aini Hospital is the lead sponsor of 283 studies on the registry; 33 are open to participants now.
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Exclusion Criteria:
Patients in this group will receive TAPB with dexamethasone as an adjuvant to local anesthetic.
Drug: TAPB with dexamethasone as an adjuvant to local anesthetics
Patients in this group will receive TAPB with methylprednisolone as an adjuvant to local anesthetic.
Drug: TAPB with methylprednisolone as an adjuvant to local anesthetics
patients will receive TAPB with dexamethasone as an adjuvant to bupivacaine and lidocaine local anesthetics
patients will receive TAPB with methylprednisolone as an adjuvant to bupivacaine and lidocaine local anesthetics
postoperative pain score by Visual analogue score at 48 hrs.
postoperative pain score by Visual analogue score at 48 hours Post operative pain assessment using Visual analogue score which is numerical score from (0-10) (zero refer to no pain and 10 refer to the worst pain)
Time frame: 48 hours
Time to first analgesic request of rescue analgesia
Time to first analgesic request of nalbuphine as a rescue analgesia
Time frame: 24 hours
Total consumption of Nalbuphine in 1st 24 hours
Total consumption of Nalbuphine in 1st 24 hours
Time frame: 24 hours
Plan to share: No
No publications or documents are linked to this record.
Ran from Dec 2023 to primary completion in Apr 2024, 4 months.
Of 314 non-industry interventional studies with no phase under Acute Pain, half reached primary completion within 11 months of starting (the median), counting those still running; a quarter within 5 and three quarters within 22. This study's 4 months is below that.
Counting every sponsor, half of 318 studies reached it within 11 months; a quarter within 5 and three quarters within 22.
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This study is completed, as verified in Apr 2024. You cannot join it, but the record below documents what was studied.
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