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CompletedNCT06128707Updated Oct 26, 2024

Vestibulo-Ocular Reflex Function in Individuals With Chronic Motion Sensitivity Cross-Sectional Study

An observational study in Motion Sickness, sponsored by Loma Linda University. Completed at 1 site in United States. Open to participants aged 20 Years to 40 Years. Per ClinicalTrials.gov, last updated 2024-10-26.

Sponsored by Loma Linda University · Observational

Study type
Observational
Model
Other
Time perspective
Cross-sectional
Enrollment
59
Ages
20 Years to 40 Years
Sex
All
01

Study summary

Chronic motion sensitivity refers to a sensation of unwellness caused by physical or discerned motion and has a prevalence of 28% in the general population and it is more common in women (27.3%) compared to men.

The investigators theorize that individuals with chronic motion sensitivity will have an impaired inner ear reflex and will be less physically active. Hence, the purpose of this study is to;

  1. Determine whether the function of an inner ear reflex is different between young adults with/without chronic motion sensitivity
  2. Assess relationships between reflex function and balance in young adults with/without CMS
  3. Assess relationships between physical activity and balance in young adults with/without CMS.
Read the detailed description

Chronic motion sensitivity (CMS), also known as motion sickness, refers to a sensation of unwellness caused by physical or discerned motion. CMS has a prevalence of 28% in the general population and it is more common in women (27.3%) compared to men.

Based on established evidence that individuals with chronic motion sensitivity demonstrate impaired postural stability with vestibular system impairment adjudged to be an inciting stimulus for chronic motion sensitivity, and individuals who practiced more physical and sporting activities have less motion sickness susceptibility than individuals who did not, the investigators theorize that individuals with chronic motion sensitivity will have an impaired inner ear reflex, causing them to be more reliant on other sensory systems like their muscles and joints, and their vision, we also theorize that individuals who are physically active will be less susceptible to chronic motion sensitivity.

The purpose of this study is to;

  1. Determine whether the function of an inner ear reflex is different between young adults with/without chronic motion sensitivity
  2. Assess relationships between reflex function and balance in young adults with/without CMS
  3. Assess relationships between physical activity and balance in young adults with/without CMS.

Participants between the age of 20 and 40 with and without a self-reported history of chronic motion sensitivity (i.e, experiencing nauseousness and/or dizziness during while using various means of transportation such as, car, train, bus, boat, and airplane and/or, recreational fun-fair rides and/or when exposed to conflicting visual images). Participants will be excluded if they report a medical diagnosis of central nervous system disorder, impaired cervical spine range of motion, migraines, seizure disorder, vestibular dysfunction, or any musculoskeletal dysfunction that can limit their participation in the study.

02

Conditions studied

  • Motion Sickness

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Keywords

  • Chronic motion sensitivity
03

In context

Motion Sickness

50 studies on the registry are indexed under Motion Sickness; 9 are open to participants now.

Browse Motion Sickness studies →

Lead sponsor

Loma Linda University is the lead sponsor of 306 studies on the registry; 46 are open to participants now.

Of its 29 completed or terminated interventional studies of FDA-regulated products, 23 (79%) have results posted.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
20 Years to 40 Years
Sexes eligible
All
Sampling method
Non-probability sample

Study population

Participants will be recruited from Loma Linda University and surrounding communities. The study will be conducted in the Loma Linda University Physical Therapy Department's Neuroscience Research Laboratory. Participants between the age of 20 and 30 with and without a self-reported history of chronic motion sensitivity (i.e, experiencing nauseousness and/or dizziness during while using various means of transportation such as, car, train, bus, boat, and airplane and/or, recreational fun-fair rides and/or when exposed to conflicting visual images)

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Age 20-40
  • With and without a history of CMS

Exclusion criteria

Exclusion Criteria:

  • CNS disorder
  • Impaired cervical spine ROM
  • Migraines
  • Seizures
  • Vestibular dysfunction
  • Musculoskeletal dysfunction
  • Medications causing dizziness
05

Study design

Observational model
Other
Time perspective
Cross-sectional
Enrollment
59 participants (actual)
Target follow-up
1 Day
Patient registry
Yes

Groups and cohorts

  • Chronic Motion sensitivity group

    Participants with a self-reported history of chronic motion sensitivity and who scored greater than or equal to the 30th percentile on the Motion sickness susceptibility questionnaire short form.

  • Non-Chronic Motion sensitivity Group

    Participants without a self-reported history of chronic motion sensitivity and who scored less than or equal to the 25th percentile on the Motion sickness susceptibility questionnaire short form.

06

What researchers measure

Primary outcomes

  1. Bertec vision advantage

    Scores on 4 parametters- Baseline visual acuity (Logarithm of the minimum angle of resolution LogMAR)- A measure of optotype size with lower values signifying smaller optotype size and better vision with the head static, Visual processing time (Mili seconds) this is the time taken to identify the size of the optotype, Dynamic visual acuity (Logarithm of the minimum angle of resolution LogMAR)-A measure of optotype size with lower values signifying smaller optotype size and better vision with the head dynamic, Gaze stability test (Degrees per second), this is the highest speed at which the participant can identify the optotype while the head is moving.

    Time frame: 1 day

  2. Computerized dynamic posturography with immersion virtual reality

    Average scores under 2 conditions- Condition one- Eye open, Stable platform, Condition 2 Eye open, sway referenced platform. Each condition measured gives a score known as the equillibrum score measured as age matched normative data with higher scores signifying stronger balance , and a lower scores signifying weaker balance

    Time frame: 1 day

Secondary outcomes

  1. International Physical activity questionaire short form

    Questionaire to assess physical activity

    Time frame: 1 day

Other outcomes

  1. Motion sickness susceptibility questionnaire short form

    Questionnaire used to asses motion sickness susceptibility

    Time frame: 1 day

07

Study locations

1 site
  • Loma Linda University
    Loma Linda, California 92350, United States
08

References and documents

Individual participant data

Plan to share: Undecided

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Oct 26, 2024, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT06128707
Responsible party
Sponsor
First posted
Nov 13, 2023
Start date
Sep 30, 2023
Primary completion
Feb 1, 2024
Completion
Feb 1, 2024
Last update
Oct 26, 2024

Oversight

Data monitoring committee
Yes
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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This study is completed, as verified in Oct 2024. You cannot join it, but the record below documents what was studied.

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